Abstract
The application of recombinant DNA technology to human genetics has advanced our knowledge of inherited diseases immensely. Classical genetics was very limited in its ability to probe the complexity of the human genome. The famous genetic breeding experiments in viruses, bacteria, yeast, slime mold, and fruit flies taught us a great deal about genetics in general. However, applying classical genetics to human diseases was limited by our scant knowledge of human genes. Some people doubted that the science of human genetics would ever make much progress.* Recombinant DNA technology and genetic mapping have opened the very complex human genome to direct study.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Bibliography
Antonarakis SE (1989) Diagnosis of gentic disorders at the DNA level. N Eng J Med 320: 153–163.
Budowle B, Baechtel FS, Giusti AM, Monson K (1990) Applying highly polymorphic variable number of tandem repeats loci genetic markers to identity testing. Clin Biochem 23: 287–293.
Cann, RL, Stoneking M, Wilson AC (1986) Mitochondrial DNA and human evolution. Nature 325: 31–36.
Chang JC, Kan YW (1982) A sensitive new prenatal test for sickle cell anemia. N Eng J Med 307: 30–32.
Gelehrter TD, Collins FS (1990) Principles of Medical Genetics. Williams and Wilkins, Baltimore.
Highsmith WE, Chong GL, Orr HT, Perry TR, Schaid D, Farber R, Wagner K, Knowles MR, Warwick WJ, Silverman LM, Thibodeau SN (1990) Frequency of the Phe508 mutation and correlation with XV.2c/KM-19 haplotypes in an American population of cystic fibrosis patients: Results of a collaborative study. Clin Chem 36: 1741–1746.
Lemna WK, Feldman GL, Kerem B, Fernbach SD, Zevkovith EP, O’Brien WE, Riordan JR, Collins FS, Tsui L, Beaudet AL (1990) Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Eng J Med 322: 291–296.
Pauling L, Itano HA, Singer SJ, Well IC (1949) Sickle cell anemia, a molecular disease. Science 110: 543–548.
Ross DW (1991) Mitochondrial Eve. Arch Pathol Lab Med 115: 544.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ross, D.W. (1992). Genetic Diseases. In: Introduction to Molecular Medicine . Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4076-9_5
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4076-9_5
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-97724-9
Online ISBN: 978-1-4757-4076-9
eBook Packages: Springer Book Archive