Gene Regulation and Expression

  • Dennis W. Ross


A gene is a segment of DNA consisting of codons specifying the amino acids for a protein and of control sequences which regulate gene expression. When a cell divides, the entire human genome, that is, all the DNA stored within the nucleus, must be copied. In Figure 2.1 the replication of DNA is demonstrated. The regulation of a cell’s function is controlled by altering gene expression. The steps in gene expression are (1) transcription of the gene’s DNA to RNA, (2) RNA processing to produce a spliced mRNA, (3) translation of mRNA on a polyribosome to a polypeptide chain, and (4) final protein processing to the functional tertiary form. Figures 2.2 through 2.5 illustrate the steps in this process, which will be covered in more detail later in this chapter.


Antisense Oligonucleotide mRNA Molecule Template Strand Entire Human Genome Anti Sense Oligonucleotide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  2. Stein CA, Cohen JS (1989) Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res 48: 2659–2668.Google Scholar
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Dennis W. Ross
    • 1
    • 2
  1. 1.The School of Medicine, Department of PathologyThe University of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of PathologyForsyth Memorial HospitalWinston-SalemUSA

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