Conformation-Dependent Recognition Sites

  • Klaus Kühn


The integrin-mediated interaction of cells with laminins has recently been reviewed by Aumailley et al.1 In this chapter, the structural aspects of laminin integrin interaction will be emphasized. At least seven integrins have been identified which bind to laminin (Fig. 4.3.1). They were determined by using inhibiting antibodies, affinity chromatography and more recently, adherence of cells transfected with individual integrin α-subunits. The recognition sites within laminin-1 for the integrins were mapped to distinct regions and domains using defined proteolytic laminin fragments or more recently, using fragments expressed recombinantly. The most detailed investigations were carried out with laminin-1 from the murine EHS tumor.


Recognition Site Triple Helix Coiled Coil Laminin Receptor Collagen Receptor 
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© Springer Science+Business Media Dordrecht 1997

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  • Klaus Kühn

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