Activation States of Integrins

  • Clotilde Gimond
  • Arnoud Sonnenberg

Abstract

Adhesion molecules play a major role in many physiological and developmental processes. The adhesion receptors of the integrin family are involved in the regulation of cell growth and proliferation, migration and differentiation. Integrins are transmembrane heterodimers formed by noncovalently associated α and β subunits.1 The extracellular domains of integrins mediate both cell-cell and cell-matrix interactions. Through interaction of their cytoplasmic domains with cytoskeleton associated proteins, integrins connect the outside of the cell with the cytoskeleton. Sixteen α and eight β subunits have been identified so far, constituting a family of over twenty distinct receptors. The integrin repertoire is cell-type specific and it can also change in a given cell type during development and differentiation. The expression, but also the affinity of integrins can be regulated under various physiological and pathological conditions, resulting in a change in the adhesion properties of the cell. For example, cells in suspension can be induced to aggregate, or to attach to matrix proteins. Conversely, adherent cells may receive signals that induce them to detach and migrate on a matrix substrate or through layers of cells.

Keywords

Cytoplasmic Domain Phorbol Ester Integrin Subunit Focal Contact Integrin Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Clotilde Gimond
  • Arnoud Sonnenberg

There are no affiliations available

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