Advertisement

Radiolabeling of Compounds

  • Gopal B. Saha

Abstract

In recent years, the use of compounds labeled with radionuclides has grown considerably in medical, biochemical, and other related fields. In the medical field, compounds labeled with ß --emitting radionuclides are mainly restricted to in vitro experiments and therapeutic treatment, whereas those labeled with γ-emitting radionuclides have much wider applications. The latter are particularly useful for in vivo imaging of different organs.

Keywords

Human Serum Albumin Label Compound Stannous Chloride Albumin Microsphere Sodium Pertechnetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. Bayly RJ, Evans EA (1968) Storage and stability of compounds labeled with radioisotopes. Radiochemical Centre, Amersham, EnglandGoogle Scholar
  2. Cobble JW (1964) Technetium. In : Kolthoff IM, Elving PJ (eds) Treatise on analytical chemistry, Part II, Vol 6. Wiley/Interscience, New York, p 407Google Scholar
  3. Eckelman WC, Levenson SM (1977) Radiopharmaceuticals labelled with technetium. In: Welch MJ (ed) Radiopharmaceuticals and other compounds labelled with short-lived radionuclides. Pergamon Press, New York, p 67Google Scholar
  4. Eckelman WC, Levenson SM (1978) Radiopharmaceutical chemistry of technetium and iodine. In : Rocha AFG, Harbert JC (eds) Textbook of nuclear medicine : Basic science. Lea & Febiger, Philadelphia, p 192Google Scholar
  5. Kotegov KV, Pavlov ON, Shvedov VP (1968) Technetium. In: Advances in inorganic chemistry and radiochemistry, Vol 2. Academic Press, New York, p 2Google Scholar
  6. Lathrop KA (1971) Preparation and control of 99mTc radiopharmaceuticals. In: Radiopharmaceuticals from generator-produced radionuclides. IAEA, Vienna, p 39Google Scholar
  7. Lathrop KA, Harper PV, Rich BH, et al (1973) Rapid incorporation of short-lived cyclotron produced radionuclides into radiopharmaceuticals. In : Radiopharmaceuticals and Labelled Compounds, Vol 1. IAEA, Vienna, p 471Google Scholar
  8. Lin MS (1975) Labeling proteins with 99mTc. In: Subramanian G, Rhodes BA, Cooper JF, Sodd VJ (eds) Radiopharmaceuticals. Society of Nuclear Medicine, New York, p 36Google Scholar
  9. Mani RS, Narasimhan DVS (1973) Development of kits for short-lived generator-produced radioisotopes. In: Radiopharmaceuticals and Labelled Compounds, Vol 1. IAEA, Vienna, p 135Google Scholar
  10. McFarlane AS (1958) Efficient trace-labeling of proteins with iodine. Nature 182: 53PubMedCrossRefGoogle Scholar
  11. Richards P, Steigman J (1975) Chemistry of technetium as applied to radiopharmaceuticals. In: Subramanian G, Rhodes BA, Cooper JF, Sodd VJ (eds) Radiopharmaceuticals. Society of Nuclear Medicine, New York, p 23Google Scholar
  12. Sirchis J (ed) (1964) Methods of preparing and storing labeled compounds (EUR Report 3756, d, f, e). European Atomic Energy Community (Euratom), BrusselsGoogle Scholar
  13. Smith EM (1964) Properties, uses, radiochemical purity and calibration of technetium-99m. J Nucl Med 5: 871PubMedGoogle Scholar
  14. Srivastava SC, Meinken G, Smith TD, Richards P (1977) Problems associated with stannous 99mTc-radiopharmaceutical. In : Welch MJ (ed) Radiopharmaceuticals and other compounds labelled with short-lived radionuclides. Pergamon Press, New York, p 83Google Scholar
  15. Tubis M (1966) Special iodinated compounds for biology and medicine. In: Radioactive pharmaceuticals. CONF-651111, US Atomic Energy Commission, Oak Ridge, p 281Google Scholar
  16. Tubis M, Wolf W (eds) (1976) Radiopharmacy, 1st edn. Wiley, New YorkGoogle Scholar
  17. Yallow RS, Berson SA (1966) Labeling of proteins—Problems and practices. NY Acad Sci 28:1033–1044CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Gopal B. Saha
    • 1
  1. 1.University of Arkansas for Medical SciencesLittle RockUSA

Personalised recommendations