Congestive Heart Failure

  • Jerome J. Epplin

Abstract

Congestive heart failure (CHF) is the combination of signs and symptoms of abnormal cardiac function resulting in the heart being unable to pump an adequate amount of blood to oxygenate body tissues. In practice, the working definition of heart failure is that of the heart being unable to pump effectively, either because of structural, biochemical, or mechanical abnormalities or because of excessive demands placed on it, such as severe hypertension.1 It then results in loss of work capacity. This definition eliminates other causes of inadequate oxygenation, such as volume loss or fluid overload, and cases of increased oxygen demand, such as Paget’s disease of bone, severe anemia, beriberi, arteriovenous fistula, or thyrotoxicosis.

Keywords

Congestive Heart Failure Diastolic Dysfunction Atrial Natriuretic Peptide Loop Diuretic Constrictive Pericarditis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Weber KT, Janicki JS. Pathogenesis of heart failure. Cardiol Clin North Am 1989;7:11–24.Google Scholar
  2. 2.
    Kannel WB. Epidemiological aspects of heart failure. Cardiol Clin North Am 1989;7:1–9.Google Scholar
  3. 3.
    McKee PA. The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971;285:1441–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Smith WMcF. Epidemiology of congestive heart failure. Am J Cardiol 1985;55:3A.Google Scholar
  5. 5.
    Stevenson LW. The dilated cardiomyopathies: clinical aspects. Cardiol Clin North Am 1988;6:187–218.Google Scholar
  6. 6.
    Child JS, Perloff JK. The restrictive cardiomyopathies. Cardiol Clin North Am 1988;6:289–316.Google Scholar
  7. 7.
    Benotti JR, Grossman W, Cohn PF. Clinical profile of restrictive cardiomyopathy. Circulation 1980;61:1206.PubMedCrossRefGoogle Scholar
  8. 8.
    Lindemann JP. Contractile protein alterations in heart failure. Hosp Pract 1991;26:47–52.Google Scholar
  9. 9.
    McElroy PA, Shroff SG, Weber KT. Pathophysiology of the failing heart. Cardiol Clin North Am 1989;7:25–38.Google Scholar
  10. 10.
    Braunwald E. Assessment of cardiac function. In: Braunwald E, editor. Heart disease. Philadelphia: Saunders, 1992:419.Google Scholar
  11. 11.
    Francis GS, Goldsmith SR, Levine TB, et al. The neurohumoral axis in congestive heart failure. Ann Intern Med 1984; 101:370–7.PubMedCrossRefGoogle Scholar
  12. 12.
    Goldsmith SR, Francis GS, Cowley AW. Arginine vasopressin and the renal response to water loading in congestive heart failure. Am J Cardiol 1986;58:295–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Packer M. Neurohormonal interactions and adaptations in congestive heart failure. Circulation 1988;77:721.PubMedCrossRefGoogle Scholar
  14. 14.
    Francis GS. Interaction of the sympathetic nervous system and electrolytes in congestive heart failure. Am J Cardiol 1990;65: 24E-27E.CrossRefGoogle Scholar
  15. 15.
    Geltman E. Mild heart failure: diagnosis and treatment. Am Heart J 1989;118:1277–1291.PubMedCrossRefGoogle Scholar
  16. 16.
    Braunwald E, Grossman W. Clinical aspects of heart failure. In: Braunwald E, editor. Heart disease. Philadelphia: Saunders, 1992: 444.Google Scholar
  17. 17.
    Stefandouros M, Little R. The cause and clinical significance of diastolic heart sounds. Arch Intern Med 1980;140:537–41.CrossRefGoogle Scholar
  18. 18.
    Dargie H. Interrelation of electrolytes and renin-angiotensin system in congestive heart failure. Am J Cardiol 1990;65:10.CrossRefGoogle Scholar
  19. 19.
    Calafiore P, Stewart W. Doppler echocardiographic quantitation of volumetric flow rate. Cardiol Clin 1990;8:2.Google Scholar
  20. 20.
    Grossman W Diastolic dysfunction and congestive heart failure. Circulation 1990;81 Suppl:III-1–III-7.CrossRefGoogle Scholar
  21. 21.
    Gaasch W. Diastolic dysfunction of the left ventricle: importance to the clinician. Adv Intern Med 1990;35:311–40.PubMedGoogle Scholar
  22. 22.
    Morgan J, Erny R, Allen PD, et al. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 1990;81 Suppl:III-21–III-32.Google Scholar
  23. 23.
    Labovitz A, Pearson A. Evaluation of left ventricular diastolic function: clinical relevance and recent Doppler echocardiographic insights. Am Heart J 1987; 114:4.CrossRefGoogle Scholar
  24. 24.
    Cohn J, Johnson G. Heart failure with normal ejection fraction. Circulation 1990;81 Suppl:III-48–III-53.CrossRefGoogle Scholar
  25. 25.
    Judge K, Pawitan Y, Caldwell J, et al. Congestive heart failure symptoms in patients with preserved left ventricular systolic function: analysis of the CASS registry. J Am Coll Cardiol 1991;18:377–82.PubMedCrossRefGoogle Scholar
  26. 26.
    Smith T, Braunwald E, Kelly R. The management of heart failure. In: Braunwald E, editor. Heart diseases. 4th ed. Philadelphia: Saunders, 1991.Google Scholar
  27. 27.
    Furst D. Clinically important interactions of NSAIDs with other medications. J Rheumatol 1988; 15:58.Google Scholar
  28. 28.
    Wilson J. Circulatory improvement after hydralazine or isosorbide dinitrate administration in patients with heart failure. Am J Med 1981;71:627–33.PubMedCrossRefGoogle Scholar
  29. 29.
    Cohn J, Archibald DG, Ziesche S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure. N Engl J Med 1986;314:1547–52.PubMedCrossRefGoogle Scholar
  30. 30.
    SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991;325:293–302.CrossRefGoogle Scholar
  31. 31.
    CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med 1987;316:237.Google Scholar
  32. 32.
    Pfeffer M, Lamas G, Vaughan D, et al. Effect of Captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med 1988;319:80–6.PubMedCrossRefGoogle Scholar
  33. 33.
    SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992; 327:685–91.CrossRefGoogle Scholar
  34. 34.
    Dzau V, Creager M. Progress in angiotensin-converting enzyme inhibition in heart failure. Cardiol Clin 1989;7:1.Google Scholar
  35. 35.
    Pfeffer M, Braunwald E, Moye L, et al. Effect of Captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 1992;327:669–77.PubMedCrossRefGoogle Scholar
  36. 36.
    Swedberg K, Held P, Kjekshus J, et al. Effects of the early administration of enalapril in mortality in patients with acute myocardial infarction. N Engl J Med 1992;327:678–84.PubMedCrossRefGoogle Scholar
  37. 37.
    Packer M, Lee WH, Yushak M, et al. Comparison of Captopril and enalapril in patients with severe chronic heart failure. N Engl J Med 1986;315:847–53.PubMedCrossRefGoogle Scholar
  38. 38.
    Cohn J, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1992;325:303–10.CrossRefGoogle Scholar
  39. 39.
    Smith T Digitalis, mechanisms of action and clinical use. N Engl J Med 1988;318:358–65.CrossRefGoogle Scholar
  40. 40.
    Marcus F. Pharmacokinetic interactions between digoxin and other drugs. J Am Coll Cardiol 1985;55:82A.Google Scholar
  41. 41.
    Smith T, Antman E, Friedman P, et al. Digitalis glycosides: mechanisms and manifestations of toxicity. Prog Cardiovasc Dis 1984;26:413.PubMedCrossRefGoogle Scholar
  42. 42.
    Lahiri A, Rodriques E, Carbone GP, et al. Effects of long-term treatment with calcium antagonists on left ventricular diastolic function in stable angina and heart failure. Circulation 1990;81 Suppl III:III-130–III-138.Google Scholar
  43. 43.
    Packer M, Carver J, Rodeheffer R, et al. Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med 1991;325:1468–75.PubMedCrossRefGoogle Scholar
  44. 44.
    Copeland J. Selection of patients for cardiac transplantation. Circulation 1987;75:2–9.PubMedCrossRefGoogle Scholar
  45. 45.
    Luchi R, Taffet G, Teasdale T. Congestive heart failure in the elderly. J Am Geriatr Soc 1991;39:810–25.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jerome J. Epplin

There are no affiliations available

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