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The Endocrine System

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Family Medicine

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Abstract

Classically, endocrinology has consisted of the study of hormone-secreting organs and the evaluation of hormonal activity. Hormones were considered chemical substances that, when secreted into the circulation, would affect the metabolic pathways of cells with appropriate receptors. In recent years it has been appreciated that many hormones can also act as neurotransmitters, and in addition to being secreted in the systemic circulation, hormones may also have a local effect where they are secreted. Compounds such as vitamin D are now called hormones, even though they are not produced by any one gland. Hormone action is dependent on the functional status of specific hormone receptors as well as the absolute blood level.

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References

  1. Vagenakis AG, Braverman LE: Adverse effects of iodides on thyroid function. Med Clin North Am 59: 1075–1088, 1975.

    PubMed  CAS  Google Scholar 

  2. Schimmel M, Utiger RD: Thyroidal and peripheral production of thyroid hormones: review of recent findings and their clinical implications. Ann Intern Med 87: 760–768, 1977.

    Article  PubMed  CAS  Google Scholar 

  3. Kaplan MM, Utiger RD: Diagnosis of hyperthyroidism. Clin Endocrinol Metab 7: 97–113, 1978.

    Article  PubMed  CAS  Google Scholar 

  4. Braverman LE: Therapeutic considerations. Clin Endocrinol Metab 7: 221–239, 1978.

    Article  PubMed  CAS  Google Scholar 

  5. McGregor AM, Petersen MM, McLachlan SM, Rooke P, Smith BR, Hall R: Carbimazole and the autoimmune response in Graves’ disease. N Engl J Med 303: 302–307, 1980.

    Article  PubMed  CAS  Google Scholar 

  6. Mackin JF, Canary JJ, Pittman CS: Thyroid storm and its management. N Engl J Med 291: 1396–1397, 1974.

    Article  PubMed  CAS  Google Scholar 

  7. Hurley JR. Thyroiditis. Disease-A-Month 24: 3–65, 1977.

    Article  Google Scholar 

  8. Vander JB, Gaston EA, Dawber TR: The significance of nontoxic thyroid nodules: final report of a 15-year study of the incidence of thyroid malignancy. Ann Intern Med 69: 537, 1968.

    Article  PubMed  CAS  Google Scholar 

  9. Sampson RJ, Woolner LB, Bahn RC, Kurland LT: Occult thyroid carcinoma in Olmstead County, Minnesota: prevalence at autopsy compared with that in Hiroshima and Nagasaki, Japan. Cancer 34: 2072–2076, 1974.

    Article  PubMed  CAS  Google Scholar 

  10. Blum M, Rothschild M: Improved nonoperative diagnosis of the solitary “cold” thyroid nodule. JAMA 243: 242–245, 1980.

    Article  PubMed  CAS  Google Scholar 

  11. Sherwin RS, Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am 62: 695–711, 1978.

    PubMed  CAS  Google Scholar 

  12. Fajans SS, Cloutier MC, Crowther RL: Clinical and etiologic heterogeneity of idiopathic diabetes mellitus. Diabetes 27: 1112–1124, 1978.

    PubMed  CAS  Google Scholar 

  13. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039–1056, 1979.

    Google Scholar 

  14. Anderson JW, Midgley WR, Wedman B: Fiber and diabetes. Diabetes Care 2: 369–379, 1979.

    Article  PubMed  CAS  Google Scholar 

  15. Skillman TG, Feldman JM: The pharmacology of sulfonylureas. Am J Med 70: 361, 1981.

    Article  PubMed  CAS  Google Scholar 

  16. Kahn CR, Rosenthal AS: Immunologic reactions to insulin: insulin allergy, insulin resistance, and the autoimmune insulin syndrome. Diabetes Care 2: 283–294, 1979.

    PubMed  CAS  Google Scholar 

  17. Galloway JA, Bressler R: Insulin treatment in diabetes. Med Clin North Am 62: 663–679, 1978.

    PubMed  CAS  Google Scholar 

  18. Rizza RA, Gerich JE, Haymond MW, et al.: Control of blood sugar in insulin-dependent diabetes: comparison of an artificial endocrine pancreas, continuous subcutaneous insulin infusion, and intensified conventional insulin therapy. N Engl J Med 303: 1313–1318, 1980.

    Article  PubMed  CAS  Google Scholar 

  19. Skyler JS, Lasky IA, Skyler DL, Robertson EG, Mintz DH: Home blood glucose monitoring as an aid in diabetes management. Diabetes Care 1: 150–157, 1978.

    Article  PubMed  CAS  Google Scholar 

  20. Kreisberg RA: Diabetic ketoacidosis: new concepts and trends in pathogenesis and treatment. Ann Intern Med 88: 681–695, 1978.

    Article  PubMed  CAS  Google Scholar 

  21. Guisado R, Arieff AI: Neurologic manifestations of diabetic comas: correlation with biochemical alterations in the brain. Metabolism 24: 665–679, 1975.

    Article  PubMed  CAS  Google Scholar 

  22. Ellenberg M: Diabetic neuropathy: clinical aspects. Metabolism 25: 1627, 1976.

    Article  PubMed  CAS  Google Scholar 

  23. Taub S, Mariani A, Barkin JS: Gastrointestinal manifestations of diabetes mellitus. Diabetes Care 2: 437–446, 1979.

    Article  Google Scholar 

  24. L’Esperance FA: Diabetic retinopathy. Med Clin North Am 62: 767–783, 1978.

    PubMed  Google Scholar 

  25. Mintz, DH, Skyler JS, Chez RA: Diabetes mellitus and pregnancy. Diabetes Care 1: 49–63, 1978.

    PubMed  CAS  Google Scholar 

  26. Fajans SS, Floyd JC: Fasting hypoglycemia in adults. N Engl J Med 294: 766–772, 1976.

    Article  PubMed  CAS  Google Scholar 

  27. Permutt MA: Postprandial hypoglycemia. Diabetes 25: 719–733, 1976.

    PubMed  CAS  Google Scholar 

  28. Yager J, Young RT: Sounding board: non-hypoglycemia is an epidemic condition. N Engl J Med 291: 907–908, 1974.

    Article  PubMed  CAS  Google Scholar 

  29. Permutt MA, Delmez J, Stenson W: Effects of carbohydrate restriction on the hypoglycemic phase of the glucose tolerance test. J Clin Endocrinol Metab 43: 1088 1093, 1976.

    Article  PubMed  CAS  Google Scholar 

  30. Fajans SS, Floyd JC: Diagnosis and medical management of insulinomas. Ann Rev Med 30: 313–329, 1979.

    Article  PubMed  CAS  Google Scholar 

  31. Gordon T. Kannel WB: Obesity and cardiovascular disease: the Framingham study. Clin Endocrinol Metab 5: 367–375, 1976.

    Article  PubMed  CAS  Google Scholar 

  32. Stuart RB: Behavioral control of overeating. Behav Res Ther 5: 357–365, 1967.

    Article  Google Scholar 

  33. Bistrain BR: Recent developments in the treatment of obesity with particular reference to semistarvation ketogenic regimens. Diabetes Care 6: 379–384, 1978.

    Article  Google Scholar 

  34. Lantigua RA, Amatruda JM, Biddle TL, Forbes GB, Lockwood DH: Cardiac arrhythmias associated with a liquid protein diet for the treatment of obesity. N Engl J Med 303: 735–738, 1980.

    Article  PubMed  CAS  Google Scholar 

  35. Brunzell JD, Chait A, Bierman EL: Pathophysiology of lipoprotein transport. Metabolism 27: 1109–1126, 1978.

    Article  PubMed  CAS  Google Scholar 

  36. Miller GJ: High density lipoproteins and atherosclerosis. Ann Rev Med 31: 97–108, 1980.

    Article  PubMed  CAS  Google Scholar 

  37. Brown MS, Goldstein JL: Familial hypercholesterolemia: a genetic defect in the low-density lipoprotein receptor. N Engl J Med 294: 1386–1390, 1976.

    Article  PubMed  CAS  Google Scholar 

  38. Shekelle RB, Shryock AM, Paul O, et al.: Diet, serum cholesterol, and death from coronary heart disease. N Engl J Med 304: 65–70, 1981.

    Article  PubMed  CAS  Google Scholar 

  39. Martz BL: Drug management of hypercholesterolemia. Am Heart J 97: 389–398, 1979.

    Article  PubMed  CAS  Google Scholar 

  40. Kane JP, Malloy MJ, Tun P, et al.: Normalization of low-density-lipoprotein levels in the heterozygous familial hypercholesterolemia with a combined drug regimen. N Engl J Med 304: 251–258, 1981.

    Article  PubMed  CAS  Google Scholar 

  41. Oliver MF: Cholesterol, coronaries, clofibrate and death. N Engl J Med 24: 1360–1361, 1978.

    Article  Google Scholar 

  42. Weisberg LA, Zimmerman EA, Frantz AG: Diagnosis and evaluation of patients with an enlarged sella turcica. Am J Med 61: 590–596, 1976.

    Article  PubMed  CAS  Google Scholar 

  43. Martin JB, Reichlin S, Brown GM: Clinical approach to diagnosis of hypothalamic-pituitary disease: neurologic and roentgenographic aspects. In: Plum F, McDowell FH (eds.) Clinical Neuroendocrinology. Philadelphia, FA Davis Company, 1977, pp. 305–321.

    Google Scholar 

  44. Burrow GN, Wortzman G, Rewcastle NB, Holgate RC, Kovacs K: Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 304: 156–158, 1981.

    Article  PubMed  CAS  Google Scholar 

  45. Abboud CF, Laws ER Jr.: Clinical endocrinologic approach to hypothalamic-pituitary disease. J Neurosurg 51: 271–291, 1979.

    Article  PubMed  CAS  Google Scholar 

  46. Gemzell C, Wang CF: Outcome of pregnancy in women with pituitary adenoma. Fertil Steril 31: 363–372, 1979.

    PubMed  CAS  Google Scholar 

  47. Weisberg LA: Asymptomatic enlargement of the sella turcica. Arch Neurol 32: 483–485, 1975.

    Article  PubMed  CAS  Google Scholar 

  48. Martin JB, Reichlin S, Brown GM: Treatment of hypo-thalamic-pituitary disease. In: Plum F, McDowell FH (eds.) Clinical Neuroendocrinology. Philadelphia, FA Davis Company, 1977, pp. 349–74.

    Google Scholar 

  49. Moses AM, Miller M, Streeten DHP: Pathophysiologic and pharmacologic alterations in the release and action of ADH. Metabolism 25: 697–721, 1976.

    Article  PubMed  CAS  Google Scholar 

  50. Hamill PVV, Drizd TA, Johnson CL, Reed RB, Roche AF, Moore WM: Physical growth: National Center for Health Statistics percentiles. Am J Clin Nutr 32: 607629, 1979.

    PubMed  CAS  Google Scholar 

  51. Van WykJJ, Underwood LE: Growth hormone, somatomedins, and growth failure. Hosp Pract 13: 57–67, 1978.

    Google Scholar 

  52. Irvine WJ, Barnes EW: Adrenocortical insufficiency. Clin Endocrinol Metab 1: 549–593, 1972.

    Article  Google Scholar 

  53. Gold EM: The Cushing syndromes: changing views of diagnosis and treatment. Ann Intern Med 90: 829–844, 1979.

    Article  PubMed  CAS  Google Scholar 

  54. Grim CE, Luft FC, Weinberger MH, Grim CM: Sensitivity and specificity of screening tests for renal vascular hypertension. Ann Intern Med 91: 617–622, 1979.

    Article  PubMed  CAS  Google Scholar 

  55. Weinberger MH, Grim CE, Hollifield JW, et al: Primary aldosteronism: diagnosis, localization, and treatment. Ann Intern Med 90: 386–395, 1979.

    Article  PubMed  CAS  Google Scholar 

  56. Engelman K: Phaeochromocytoma. Clin Endocrinol Metab 6: 769–797, 1977.

    Article  PubMed  CAS  Google Scholar 

  57. Fauci AS, Dale DC, Balow JE: Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 84: 304–315, 1976.

    Article  PubMed  CAS  Google Scholar 

  58. Byyny RL: Withdrawal from glucocorticoid therapy. N Engl J Med 295: 30–32, 1976.

    Article  PubMed  CAS  Google Scholar 

  59. Givens JR: Hirsutism and hyperandrogenism. Adv Intern Med 21: 221–247, 1976.

    PubMed  CAS  Google Scholar 

  60. Ettinger B, Goldfield EB, Burrill KC, Von Werder K, Forsham PH. Plasma testosterone stimulation-suppression dynamics in hirsute women. Am J Med 54: 195–200, 1973.

    Google Scholar 

  61. Wilson JD, Aiman J, MacDonald PC: The pathogenesis of gynecomastia. Adv Intern Med 25: 1–29, 1980.

    PubMed  CAS  Google Scholar 

  62. Spark RF, White RA, Connolly PB: Impotence is not always psychogenic: newer insights into hypothalamicpituitary-gonadal dysfunction. JAMA 243: 750–755, 1980.

    Article  PubMed  CAS  Google Scholar 

  63. Brookshaw JD: Danazol treatment of benign breast disease: a survey of U.S.A. multi-centre studies. Postgraduate Med J 55: 52–58, 1979.

    Article  Google Scholar 

  64. Urban JA, Egeli RA: Non-lactational nipple discharge. CA—A Cancer J Clinicians 28: 130–140, 1978.

    Article  CAS  Google Scholar 

  65. Benirschke K: Cytogenetics. In: Yen SSC, Jaffe RB (eds.) Reproductive Endocrinology. Philadelphia, Saunders, 1978, pp. 171–185.

    Google Scholar 

  66. Yamaguchi K, Kameya T, Abe K: Multiple endocrine neoplasia type I. Clin Endocrinol Metab 9: 261–284, 1980.

    Article  PubMed  CAS  Google Scholar 

  67. Wells SA, Ontjes DA: Multiple endocrine neoplasia type II. Ann Rev Med 27: 263–268, 1976.

    Article  PubMed  Google Scholar 

  68. Woodhouse NJY: Hypocalcaemia and hypoparathyroidism. Clin Endocrinol Metab 3: 323–343, 1974.

    Article  PubMed  CAS  Google Scholar 

  69. Breslau NA, Pak CYC: Hypoparathyroidism. Metabolism 28: 1261–1276, 1979.

    Article  PubMed  CAS  Google Scholar 

  70. Middler S, Pak CYC, Murad F, Bartter F: Thiazide diuretics and calcium metabolism. Metabolism 22: 139–146, 1973.

    Article  PubMed  CAS  Google Scholar 

  71. Stewart AF, Horst R, Deftos LJ, Cadman EC, Lang R, Broadus AR: Biochemical evaluation of patients with cancer-associated hypercalcemia. N Engl J Med 303: 1376–1383, 1980.

    Article  Google Scholar 

  72. Scholz D, Purnell D: Asymptomatic primary hyperparathyroidism: 10-year prospective study. Mayo Clin Proc 56: 473–478, 1981.

    PubMed  CAS  Google Scholar 

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Authors
  1. W. L. Jaffee
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  2. B. Z. Paulshock
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Editors and Affiliations

  1. Department of Family and Community Medicine, Bowman Gray School of Medicine of Wake Forest University, 300 South Hawthorne Road, 27103, Winston-Salem, North Carolina, USA

    Robert B. Taylor M.D. (Professor) (Professor)

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© 1983 Springer Science+Business Media New York

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Jaffee, W.L., Paulshock, B.Z. (1983). The Endocrine System. In: Taylor, R.B. (eds) Family Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4002-8_75

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  • DOI: https://doi.org/10.1007/978-1-4757-4002-8_75

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4004-2

  • Online ISBN: 978-1-4757-4002-8

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