Endometrial Hyperplasia and Epithelial Cytoplasmic Change

  • Michael T. Mazur
  • Robert J. Kurman


Endometrial hyperplasia is a nonphysiologic, noninvasive proliferation of the endometrium that results in a morphologic pattern of glands with irregular shapes and varying size.1–6 This disorder results from sustained, unopposed estrogen stimulation and presents clinically as abnormal uterine bleeding. Sometimes hyperplasia is encountered incidentally in biopsies done for other reasons, such as an infertility workup or prior to or during hormone replacement therapy. Hyperplasia can mimic a wide variety of normal physiologic changes, artifacts resulting from tissue sampling and processing, benign organic disorders, and well-differentiated adenocarcinoma. Since management of these conditions and the different forms of hyperplasia can range from no treatment to hysterectomy, correct diagnosis is essential.


Ciliated Cell Endometrial Hyperplasia Squamous Metaplasia Atypical Hyperplasia Cytologic Atypia 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Michael T. Mazur
    • 1
  • Robert J. Kurman
    • 2
    • 3
  1. 1.Crouse Irving Memorial Hospital, Health Science CenterState University of New YorkSyracuseUSA
  2. 2.Departments of Gynecology and Obstetrics and PathologyThe Johns Hopkins HospitalBaltimoreUSA
  3. 3.The Johns Hopkins University School of MedicineBaltimoreUSA

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