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Abstract

Endometritis usually is a disorder of the reproductive years, although it may occur in postmenopausal patients. Endometrial inflammation typically accompanies pelvic inflammatory disease of the upper genital tract.1,2 It may also be associated with a recent pregnancy, either an abortion or a term pregnancy. 3–5 Other possible causes include instrumentation, such as a prior biopsy, an intrauterine contraceptive device, cervical stenosis, or the presence of an organic lesion such as a polyp, leiomyoma, hyperplasia, or carcinoma.5 Endometritis typically presents with intermenstrual vaginal bleeding, and sometimes it causes menorrhagia. Since this disorder also may be associated with infertility, it is important to recognize it, both for the therapy and for the prognosis of the infertile patient.6,7 In one study, 8% of outpatient endometrial biopsies showed endometritis.8

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References

  1. Kiviat NB, Wolner-Hanssen P, Eschenbach DA, Wasserheirt JN, Paavonen JA, et al: Endometrial histopathology in patients with culture-proved upper genital tract infection and laparoscopically diagnosed acute salpingitis. Am J Surg Pathol 1990;14:167–175.

    Article  PubMed  CAS  Google Scholar 

  2. Paavonen J, Aine R, Teisala K, Heinonen PK, Punnonen R: Comparison of endometrial biopsy and peritoneal fluid cytologic testing with laparos-copy in the diagnosis of acute pelvic inflammatory disease. Am J Obstet Gynecol 1985; 151:645–650.

    PubMed  CAS  Google Scholar 

  3. Gadena D, Cavanzo FJ, Leone GL, Taylor HB: Chronic endometritis. A comparative clinico-pathologic study. Obstet Gynecol 1973;41:733–738.

    Google Scholar 

  4. Dallenbach-Hellweg G: Histopathology of the Endometrium. 4th ed. New York: Springer-Verlag, 1987.

    Book  Google Scholar 

  5. Rotterdam H: Chronic endometritis. A clinico-pathologic study. Pathol Annu 1978;13:209–231.

    PubMed  Google Scholar 

  6. Czernobilsky B: Endometritis and infertility. Fertil Steril 1978;30:119–130.

    PubMed  CAS  Google Scholar 

  7. Wallach EE: The uterine factor in infertility. Fertil Steril 1972;23:138–158.

    PubMed  CAS  Google Scholar 

  8. Greenwood SM, Moran JJ: Chronic endometritis. Morphologic and clinical observations. Obstet Gynecol 1981;58:176–184.

    PubMed  CAS  Google Scholar 

  9. Winkler B, Reumann W, Mitao M, Gallo L, Richart RM, et al: Chlamydial endometritis. A histological and immunohistochemical analysis. Am J Surg Pathol 1984;8:771–778.

    Article  PubMed  CAS  Google Scholar 

  10. Buckley CH, Fox H: Biopsy Pathology of the Endometrium. New York: Raven Press, 1989.

    Google Scholar 

  11. Kurman RJ, Mazur MT: Benign diseases of the endometrium. In: Blaustein’s Pathology of the Female Genital Tract. 4th ed. Kurman RJ, ed. News York: Springer-Verlag, 1994;367–409.

    Chapter  Google Scholar 

  12. Crum CP, Egawa K, Fenoglio CM, Richart RM: Chronic endometritis. The role of immunohisto-chemistry in the detection of plasma cells. Am J Obstet Gynecol 1983;147:812–815.

    PubMed  CAS  Google Scholar 

  13. Young RH, Harris NL, Scully RE: Lymphoma-like lesions of the lower female genital tract. A report of 16 cases. Int J Gynecol Pathol 1985; 4:289–299.

    Article  PubMed  CAS  Google Scholar 

  14. Ferry JA, Young RH: Malignant lymphoma, pseu-dolymphoma, and hematopoietic disorders of the female genital tract. Pathol Annu 1991;26:227–263.

    PubMed  Google Scholar 

  15. Skensved H, Hansen A, Vetner M: Immunoreac-tive endometritis. Br J Obstet Gynaecol 1991; 98:578–582.

    Article  PubMed  CAS  Google Scholar 

  16. Miko TL, Lampe LG, Thomazy VA, Moinar P, Endes P: Eosinophilie endomyometritis associated with diagnostic curettage. Int J Gynecol Pathol 1988;7:162–172.

    Article  PubMed  CAS  Google Scholar 

  17. Ladefoged G, Lorentzen M: Xanthogranulomatous inflammation of the female genital tract. His-topathology 1988;13:541–551.

    CAS  Google Scholar 

  18. Russack V, Lammers RJ: Xanthogranulomatous endometritis. Arch Pathol Lab Med 1990; 114: 929–932.

    PubMed  CAS  Google Scholar 

  19. Lopez JI, Nevado M: Exuberant xanthogranulo-matous-like reaction following endometrial curettage. Histopathology 1989;15:315–322.

    Article  PubMed  CAS  Google Scholar 

  20. Shintaku M, Sasaki M, Baba Y: Ceroid-containing histiocytic granuloma of the endometrium. Histopathology 1991;18:169–172.

    Article  PubMed  CAS  Google Scholar 

  21. Paavonen J, Aine R, Teisala K, Heinonen PK, Punonen R, et al: Chlamydial endometritis. J Clin Pathol 1985;38:726–732.

    Article  PubMed  CAS  Google Scholar 

  22. Bazaz-Malik G, Maheshwari B, Lal N: Tuberculous endometritis. A clinicopathological study of 1000 cases. Br J Obstet Gynaecol 1983;90:84–86.

    Article  PubMed  CAS  Google Scholar 

  23. Nogales-Ortiz F, Tarancon I, Nogales FF: The pathology of female genital tuberculosis. A 31-year study of 1436 cases. Obstet Gynecol 1979; 53:422–428.

    PubMed  CAS  Google Scholar 

  24. Shireman PK: Endometrial tuberculosis acquired by a health care worker in a clinical laboratory. Arch Pathol Lab Med 1992; 116: 521–523.

    PubMed  CAS  Google Scholar 

  25. Schaefer G, Marcus RS, Kramer EE: Postmenopausal endometrial tuberculosis. Am J Obstet Gynecol 1972;112:681–687.

    PubMed  CAS  Google Scholar 

  26. Govan ADT: Tuberculous endometritis. J Pathol Bacteriol 1962;83:363–372.

    Article  PubMed  CAS  Google Scholar 

  27. Frank TS, Himebaugh KS, Wilson MD: Granulomatous endometritis associated with histologically occult cytomegalovirus in a healthy patient. Am J Surg Pathol 1992;16:716–720.

    Article  PubMed  CAS  Google Scholar 

  28. Ho K-L: Sarcoidosis of the uterus. Hum Pathol 1979;10:219–222.

    Article  PubMed  CAS  Google Scholar 

  29. Ferryman SR, Stephens M, Gough D: Necrotising granulomatous endometritis following endometrial ablation therapy. Br J Obstet Gynaecol 1992;99:928–930.

    Article  PubMed  CAS  Google Scholar 

  30. Ashworth MI, Moss GT, Kenyon WE: Granulomatous endometritis following hysteroscopic resection of the endometrium. Histopathology 1991;18:185–187.

    Article  PubMed  CAS  Google Scholar 

  31. Sayage L, Gunby R, Gonwa T, Husberg B, Goldstein R, et al: Cytomegalovirus endometritis after liver transplantation. Transplantation 1990;49: 815–817.

    Article  PubMed  CAS  Google Scholar 

  32. Brodman M, Deligdisch L: Cytomegalovirus endometritis in a patient with AIDS. Mt Sinai J Med (NY) 1986;53:673–675.

    CAS  Google Scholar 

  33. Dehner LP, Askin FB: Cytomegalovirus endometritis: Report of a case associated with spontaneous abortion. Obstet Gynecol 1975;45:211–214.

    PubMed  CAS  Google Scholar 

  34. McCracken AW, A’Agostino AN, Brucks AB, Kingsley WB: Acquired cytomegalovirus infection presenting as viral endometritis. Am J Clin Pathol 1974;61:556–560.

    PubMed  CAS  Google Scholar 

  35. Goldman RL: Herpetic inclusions in the endometrium. Obstet Gynecol 1970;36:603–605.

    PubMed  CAS  Google Scholar 

  36. Abraham AA: Herpes virus hominis endometritis in a young woman wearing an intrauterine contraceptive device. Am J Obstet Gynecol 1978; 131:340–342.

    PubMed  CAS  Google Scholar 

  37. Schneider V, Behm FG, Mumau VR: Ascending herpetic endometritis. Obstet Gynecol 1982;58: 259–262.

    Google Scholar 

  38. Duncan DA, Varner RE, Mazur MT: Uterine herpes virus infection with mutifocal necrotizing endometritis. Hum Pathol 1989;20:1021–1024.

    Article  PubMed  CAS  Google Scholar 

  39. Mazur MT, Hendrickson MR, Kempson RL: Optically clear nuclei. An alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–423.

    Article  PubMed  CAS  Google Scholar 

  40. Dardi LE, Ariano L, Ariano MC, Gould VE: Arias-Stella reaction with prominent nuclear pseudoinclusions simulating herpetic endometritis. Diag Gynecol Obstet 1982;4:127–132.

    CAS  Google Scholar 

  41. Home HW, Hertig AT, Kundsin RB, Kosasa TS: Sub-clinical endometrial inflammation and T-my-coplasma. A possible cause of human reproductive failure. Int J Fertil 1973;18:226–231.

    Google Scholar 

  42. Burke RK, Hertig AT, Miele CA: Prognostic value of subacute focal inflammation of the endometrium, with special reference to pelvic adhesions as observed on laparoscopic examination. An eight-year review. J Reprod Med 1985;30:646–650.

    PubMed  CAS  Google Scholar 

  43. Khatamee MA, Sommers SC: Clinicopathologic diagnosis of mycoplasma endometritis. Int J Fertil 1989;34:52–59.

    PubMed  CAS  Google Scholar 

  44. O’Brien PK, Roth-Moyo LA, Davis BA: Pseudo-sulfur granules associated with intrauterine contraceptive devices. Am J Clin Pathol 1981;75:822–825.

    PubMed  Google Scholar 

  45. Bhagavan BS, Ruffier J, Shinn B: Pseudoactinomycotic radiate granules in the lower female genital tract. Relationship to the Splendore-Hoeppli phenomenon. Hum Pathol 1982;13:898–904.

    Article  PubMed  CAS  Google Scholar 

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Mazur, M.T., Kurman, R.J. (1995). Endometritis. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3943-5_7

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  • DOI: https://doi.org/10.1007/978-1-4757-3943-5_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3945-9

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