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Diagnosis of Endometrial Biopsies and Curettings pp 109–130Cite as

Effects of Hormones

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Abstract

Women receive hormone preparations for a variety of reasons, including birth control, dysfunctional uterine bleeding, perimenopausal and postmenopausal symptoms, endometriosis, endometrial hyperplasia and carcinoma, breast carcinoma, and certain types of infertility. Usually the exogenous hormone is some form of progestin, but estrogenic and even androgenic hormones are used for some disorders. The endometrium shows the effects of these hormones.

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References

  1. Speroff L, Glass RH, Kase NG: Clinical Gynecologic Endocrinology and Infertility. 4th ed. Baltimore: Williams & Wilkins, 1989.

    Google Scholar 

  2. Schiff I: Menopause. In: Gynecology: Principles and Practice. Kistner RW, ed. Chicago: Year Book Medical Publishers, 1986;565–582.

    Google Scholar 

  3. Grady D, Rubin SM, Petitti DB, Fox CS, Black D, et al: Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med 1992;117:1016–1037.

    PubMed  CAS  Google Scholar 

  4. Whitehead MI, Fraser D: The effects of estrogens and progestogens on the endometrium. Obstet Gynecol Clin North Am 1987;14:299–320.

    PubMed  CAS  Google Scholar 

  5. Ober W: Effects of oral and intrauterine administration of contraceptives on the uterus. Hum Pathol 1977;8:513–527.

    Article  PubMed  CAS  Google Scholar 

  6. Dallenbach-Hellweg G: Histopathology of the Endometrium. 4th ed. New York: Springer-Verlag, 1987.

    Book  Google Scholar 

  7. Kurman RJ, Mazur MT: Benign diseases of the endometrium. In: Blaustein’s Pathology of the Female Genital Tract. 4th ed. Kurman RJ, ed. New York: Springer-Verlag, 1994;367–409.

    Chapter  Google Scholar 

  8. Hendrickson MR, Kempson RL: Surgical Pathology of the Uterine Corpus (Major Problems in Pathology series). Volume 12. Philadelphia: W.B. Saunders, 1980.

    Google Scholar 

  9. Deligdisch L: Effects of hormone therapy on the endometrium. Mod Pathol 1993;6:94–106.

    PubMed  CAS  Google Scholar 

  10. Hesla, J. Kurman R, Rock J: Histologic effects of oral contraceptives on the uterine corpus and cervix. Semin Reprod Endocrinol 1989:7:213–219.

    Article  Google Scholar 

  11. Moyer DL, deLignieres B, Driguez P, Pez JP: Prevention of endometrial hyperplasia by progesterone during long-term estradiol replacement: Influence of bleeding pattern and secretory changes. Fertil Steril 1993;59:992–997.

    PubMed  CAS  Google Scholar 

  12. Dockerty MB, Smith RA, Symmonds RE: Pseudo-malignant endometrial changes induced by administration of new synthetic progestins. Staff Meetings of the Mayo Clinic 1959;34:321–328.

    CAS  Google Scholar 

  13. Cruz-Aquino M, Shenker L, Blaustein A: Pseudo-sarcoma of the endometrium. Obstet Gynecol 1967;29:93–96.

    PubMed  CAS  Google Scholar 

  14. Clement PB, Scully RE: Idiopathic postmenopausal decidual reaction of the endometrium. Int J Gynecol Pathol 1988;7:152–161.

    Article  PubMed  CAS  Google Scholar 

  15. Iezzoni JC, Mills SE: Predecidualized signet-ring stromal cells mimicking adenocarcinoma in endometrial biopsy specimens. Mod Pathol 1994;70: 90A (abstract).

    Google Scholar 

  16. Bernardini L, Araujo FE, Balmaceda JP: A case of permanent endometrial hypotrophy after long-term use of oral contraceptives. Hum Reprod 1993;8:543–546.

    PubMed  CAS  Google Scholar 

  17. Gelfand MM, Ferenczy A: A prospective 1-year study of estrogen and progestin in postmenopausal women: Effects on the endometrium. Obstet Gynecol 1989;74:398–402.

    PubMed  CAS  Google Scholar 

  18. Mishell DR, Jr: Menopause. In: Comprehensive Gynecology. Herbst AL, Mishell DR, Jr, Sten-chever MA, Droegemueller W, eds. St. Louis: Mosby Year Book, 1992; 1245–1280.

    Google Scholar 

  19. Byrjalsen I, Thormann L, Meinecke B, Riis BJ, Christiansen C: Sequential estrogen and progestogen therapy—Assessment of progestational effects on the postmenopausal endometrium. Obstet Gynecol 1992;79:523–528.

    PubMed  CAS  Google Scholar 

  20. Magos AL, Brewster E, Singh R, O’Dowd T, Brincai M: Amenorrhea and endometrial atrophy with continuous oral estrogens and progestogen therapy in post-menopausal women. Obstet Gynecol 1985;65:496–499.

    PubMed  CAS  Google Scholar 

  21. Hillard TC, Siddle NC, Whitehead MI, Fraser DI, Pryse-Davies J: Continuous combined conjugated equine estrogen-progestogen therapy—effects of medroxyprogesterone acetate and norethindrone acetate on bleeding patterns and endometrial histologic diagnosis. Am J Obstet Gynecol 1992; 167:1–7.

    PubMed  CAS  Google Scholar 

  22. Te Linde RW, Henriksen E: Decidualike changes in the endometrium without pregnancy. Am J Obstet Gynecol 1940;39:733–749.

    Google Scholar 

  23. Dallenbach-Hellweg G, Hohagen F: On the problem of premature decidualization induced by the embryo transfer. Lab Invest 1985;52: 17A. (Abstract)

    Google Scholar 

  24. Tamada T, Okagaki T, Maruyama M, Matsumoto S: Endometrial histology associated with an intrauterine contraceptive device. Am J Obstet Gynecol 1967;98:811–817.

    PubMed  CAS  Google Scholar 

  25. Bonney WA, Glasser SR, Clewe TH, Noyes RW, Cooper CL: Endometrial response to the intrauterine device. Am J Obstet Gynecol 1966;96: 101–113.

    PubMed  Google Scholar 

  26. Andersson M, Storm HH, Mouridsen HT: Incidence of new primary cancers after adjuvant therapy and radiotherapy for early breast cancer. J Natl Cancer Inst 1991;83:1013–1017.

    Article  PubMed  CAS  Google Scholar 

  27. Segna RA, Dottino RR, Deligdisch L, Cohen CJ: Tamoxifen and endometrial cancer. Mt Sinai J Med 1992;59:416–418.

    PubMed  CAS  Google Scholar 

  28. Magriples U, Naftolin F, Schwartz PE, Carcangiu ML: High-grade endometrial carcinoma in tamoxifen-treated breast cancer patients. J Clin Oncol 1993;11:485–490.

    PubMed  CAS  Google Scholar 

  29. Gusberg SB: Tamoxifen for breast cancer: Associated endometrial cancer. Cancer 1990;65: 1463–1464.

    Article  PubMed  CAS  Google Scholar 

  30. Fornander T, Cedermark B, Mattsson A, Skoog L, Theve T, et al: Adjuvant tamoxifen in early breast cancer: Occurrence of new primary cancers. Lancet 1989;1:117–120.

    Article  PubMed  CAS  Google Scholar 

  31. Seoud MF, Johns J, Weed JC, Jr: Gynecologic tumors in tamoxifen-treated women with breast cancer. Obstet Gynecol 1993;82:165–169.

    PubMed  CAS  Google Scholar 

  32. Fisher B, Costantino JP, Redmond CK, Fisher ER, Wickerham DL, et al: Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14, J Natl Cancer Inst 1994;86:527–537.

    Article  PubMed  CAS  Google Scholar 

  33. Nuovo MA, Nuovo GJ, McCaffrey FM, Levine RU, Barron B, et al: Endometrial polyps in postmenopausal patients receiving tamoxifen. Int J Gynecol Pathol 1989;8:125–131.

    Article  PubMed  CAS  Google Scholar 

  34. Corley D, Rowe J, Curtis MT, Hogan WM, Noum-off JS, et al: Postmenopausal bleeding from unusual endometrial polyps in women on chronic tamoxifen therapy. Obstet Gynecol 1992;79:111–116.

    PubMed  CAS  Google Scholar 

  35. Cohen I, Shapira J, Altaras M, Cordoba M, Rosen D, et al: Endometrial decidual changes in a postmenopausal woman treated with tamoxifen and megestrol acetate. Br J Obstet Gynaecol 1992; 99:773–774.

    Article  PubMed  CAS  Google Scholar 

  36. Lahti E, Blanco G, Kauppila A, Apajasarkkinen M, Taskinen PJ, et al: Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen. Obstet Gynecol 1993;81:660–664.

    PubMed  CAS  Google Scholar 

  37. Wentz AC: Endometrial biopsy in the evaluation of infertility. Fertil Steril 1980;33:121–124.

    PubMed  CAS  Google Scholar 

  38. Keenan JA, Herbert CM, Bush JR, Wentz AC: Diagnosis and management of out-of-phase endometrial biopsies among patients receiving clomi-phene citrate for ovulation induction. Fertil Steril 1989;51:964–967.

    PubMed  CAS  Google Scholar 

  39. Cook CL, Schroeder JA, Yussman MA, Sanfilippo JS: Induction of luteal phase defect with clomi-phene citrate. Am J Obstet Gynecol 1984; 149: 613–616.

    PubMed  CAS  Google Scholar 

  40. Van Hall EV, Mastboom JL: Luteal phase insufficiency in patients treated with clomiphene. Am J Obstet Gynecol 1969;103:165–171.

    PubMed  Google Scholar 

  41. Yeko TR, Bardawil WA, Nicosia SM, Dawood MY, Maroulis GB: Histology of midluteal corpus luteum and endometrium from clomiphene citrate-induced cycles. Fertil Steril 1992;57:28–32.

    PubMed  CAS  Google Scholar 

  42. Hecht BR, Bardawil WA, Khan-Dawood FS, Dawood MY: Luteal insufficiency: Correlation between endometrial dating and integrated progesterone output in clomiphene citrate-induced cycles. Am J Obstet Gynecol 1990; 163:1986–1991.

    PubMed  CAS  Google Scholar 

  43. Lamb EJ, Colliflower WW, Williams JW: Endometrial histology and conception rates after clomiphene citrate. Obstet Gynecol 1972;39:389–396.

    PubMed  CAS  Google Scholar 

  44. Benda JA: Glomiphene’s effect on endometrium in infertility. In J Gynecol Pathol 1992; 11:273–282.

    Article  CAS  Google Scholar 

  45. Birkenfeld A, Navot D, Levij IS, Laufer N, Beier-Hellwig K, et al: Advanced secretory changes in the proliferative human endometrial epithelium following clomiphene citrate treatment. Fertil Steril 1986;45:462–468.

    PubMed  CAS  Google Scholar 

  46. Thatcher SS, Donachie KM, Glasier A, Hillier SG, Baird DT: The effects of clomiphene citrate on the histology of human endometrium in regularly cycling women undergoing in vitro fertilization. Fertil Steril 1988;49:296–301.

    PubMed  CAS  Google Scholar 

  47. Li TC, Warren MA, Murphy C, Sargeant S, Cooke ID: A prospective, randomised, cross-over study comparing the effects of clomiphene citrate and cyclofenil on endometrial morphology in the luteal phase of normal, fertile women. Br J Obstet Gynaecol 1992;99:1008–1013.

    Article  PubMed  CAS  Google Scholar 

  48. Floyd WS: Danazol: Endocrine and endometrial effects. IntJ Fertil 1980;25:75–80.

    CAS  Google Scholar 

  49. Fedele L, Marchini M, Bianchi S, Baglioni A, Bocciolone L, et al: Endometrial patterns during danazol and buserelin therapy for endometriosis: Comparative structural and ultrastructural study. Obstet Gynecol 1990:76:79–84.

    PubMed  CAS  Google Scholar 

  50. Soh E, Sato K: Clinical effects of danazol on endometrial hyperplasia in menopausal and postmenopausal women. Cancer 1990;66:983–988.

    Article  PubMed  CAS  Google Scholar 

  51. Wentz AC, Jones GS, Sapp KC, King TM: Progestational activity of danazol in the human female subject. Am J Obstet Gynecol 1976; 126:378–384.

    PubMed  CAS  Google Scholar 

  52. Marchini M, Fedele L, Bianchi S, Dinola G, Nava S, et al: Endometrial patterns during therapy with danazol or gestrinone for endometriosis—Structural and ultrastructural study. Hum Pathol 1992;23:51–56.

    Article  PubMed  CAS  Google Scholar 

  53. Jeppsson S, Mellquist P, Rannevik G: Short-term effects of danazol on endometrial histology. Acta Obstet Gynecol Scand Suppl 1984;123:41–44.

    Article  PubMed  CAS  Google Scholar 

  54. Brooks PG, Serden SP, Davos I: Hormonal inhibition of the endometrium for resectoscopic endometrial ablation. Am J Obstet Gynecol 1991; 164:1601–1608.

    PubMed  CAS  Google Scholar 

  55. Reshef E, Segars JH, Hill GA, Pridham DD, Yussman MA, et al: Endometrial inadequacy after treatment with human menopausal gonadotropin/human chorionic gonadotropin. Fertil Steril 1990;54:1012–1016.

    PubMed  CAS  Google Scholar 

  56. Bonhoff A, Naether O, Johannisson E, Bohnet HG: Morphometric characteristics of endometrial biopsies after different types of ovarian stimulation for infertility treatment. Fertil Steril 1993;59:560–566.

    PubMed  CAS  Google Scholar 

  57. Campbell BF, Phipps WR, Nagel TC: Endometrial biopsies during treatment with subcutaneous pulsatile gonadotropin releasing hormone and luteal phase human chorinonic gonadotropins. Int J Fertil 1988;33:329.

    PubMed  CAS  Google Scholar 

  58. Sterzik K, Dallenbach C, Schneider V, Sasse V, Dallenbach-Hellweg G: In vitro fertilization: The degree of endometrial insufficiency varies with the type of ovarian stimulation. Fertil Steril 1988;50: 457–462.

    PubMed  CAS  Google Scholar 

  59. Garcia JE, Acosta AA, Hsiu J-G, Jones HW, Jr: Advanced endometrial maturation after ovulation induction with human menopausal gonado-tropin/human chorionic gonadotropin for in vitro fertilization. Fertil Steril 1984;41:31–35.

    PubMed  CAS  Google Scholar 

  60. Sharma V, Whitehead M, Mason B, Pryse-Davies J, Ryder T, et al: Influence of superovulation on endometrial and embryonic development. Fertil Steril 1990;53:822–829.

    PubMed  CAS  Google Scholar 

  61. Benadiva CA, Metzger DA: Superovulation with human menopausal gonadotropins is associated with endometrial gland-stroma dyssynchrony. Fertil Steril 1994;61:700–704.

    PubMed  CAS  Google Scholar 

  62. Macrow PJ, Li T-C, Seif MW, Buckley CH, El-stein M: Endometrial structure after superovula-tion: A prospective controlled study. Fertil Steril 1994;61:696–699.

    PubMed  CAS  Google Scholar 

  63. Casper RF: Clinical uses of gonadotropin-releas-ing hormone analogues. Can Med Assoc J 1991; 144:153–158.

    CAS  Google Scholar 

  64. Lemay A, Jean C, Faure N: Endometrial histology during intermittent intranasal luteinizing hormone-releasing hormone (LH-RH) agonist sequentially combined with an oral progestogen as an antiovulatory contraceptive approach. Fertil Steril 1987;48:775–782.

    PubMed  CAS  Google Scholar 

  65. Spitz IM, Bardin CW: Mifepristone (RU 486)—A modulator of progestin and glucocorticoid action. N Engl J Med 1993;329:404–412.

    Article  PubMed  CAS  Google Scholar 

  66. Swahn ML, Bygdeman M, Cekan S, Xing S, Masironi B, et al: The effect of RU 486 administered during the early luteal phase on bleeding pattern, hormonal parameters and endometrium. Hum Reprod 1990;5:402–408.

    PubMed  CAS  Google Scholar 

  67. Li T-G, Dockery P, Thomas P, Rogers AW, Lenton EA, et al: The effects of progesterone receptor blockade in the luteal phase of normal fertile women. Fertil Steril 1988;50:732–742.

    PubMed  CAS  Google Scholar 

  68. Batista MC, Gartledge TP, Zellmer AW, Merino MJ, Axiotis C, et al: Delayed endometrial maturation induced by daily administration of the anti-progestin RU-486—A potential new contraceptive strategy. Am J Obstet Gynecol 1992; 167: 60–65.

    PubMed  CAS  Google Scholar 

  69. Koering MJ, Healy DL, Hodgen GD: Morphologic response of endometrium to a progesterone receptor antagonist, RU486, in monkeys. Fertil Steril 1986;45:280–287.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Crouse Irving Memorial Hospital, Health Science Center, State University of New York, Syracuse, NY, 13210, USA

    Michael T. Mazur M.D.

  2. Departments of Gynecology and Obstetrics and Pathology, The Johns Hopkins Hospital, Baltimore, MD, 21287, USA

    Robert J. Kurman M.D.

  3. The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA

    Robert J. Kurman M.D.

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  1. Michael T. Mazur M.D.
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  2. Robert J. Kurman M.D.
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© 1995 Springer Science+Business Media New York

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Mazur, M.T., Kurman, R.J. (1995). Effects of Hormones. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3943-5_6

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  • DOI: https://doi.org/10.1007/978-1-4757-3943-5_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3945-9

  • Online ISBN: 978-1-4757-3943-5

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