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Abstract

This chapter specifically addresses uterine bleeding due to alterations in the normal cyclical hormonal stimulation of the endometrium. This type of bleeding is commonly referred to as dysfunctional uterine bleeding (DUB).1–4 Clinically, DUB indicates ovulatory dysfunction. By definition, DUB excludes postmenopausal bleeding or bleeding due to the presence of specific pathologic processes such as inflammation, polyps, hyperplasia, carcinoma, exogenous hormones, and complications of pregnancy. The endometrial changes associated with DUB are important to recognize, because they may be confused with more serious lesions such as hyperplasia.

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References

  1. Speroff L, Glass RH, Kase NG: Clinical Gynecologic Endocrinology and Infertility. 4th ed. Baltimore: Williams & Wilkins, 1989.

    Google Scholar 

  2. Bayer SR, DeCherney AH: Clinical manifestations and treatment of dysfunctional uterine bleeding. JAMA 1993;269:1823–1828.

    Article  PubMed  CAS  Google Scholar 

  3. Galle PC, McRae MA: Abnormal uterine bleeding. Finding and treating the cause. Postgrad Med 1993;93:73–81.

    PubMed  CAS  Google Scholar 

  4. Mishell DR, Jr: Abnormal uterine bleeding. In: Comprehensive Gynecology. Herbst AL, Mishell DR, Jr, Stenchever MA, Droegemueller W, eds. St. Louis: Mosby-Year Book, 1992; 1079–1099.

    Google Scholar 

  5. Picoff RC, Luginbuhl WH: Fibrin in the endometrial stroma: Its relation to uterine bleeding. Am J Obstet Gynecol 1964;88:642–646.

    PubMed  CAS  Google Scholar 

  6. Clement PB: Pathology of the uterine corpus. Hum Pathol 1991;22:776–791.

    Article  PubMed  CAS  Google Scholar 

  7. Zaman SS, Mazur MT: Endometrial papillary syncytial change. A nonspecific alteration associated with active breakdown. Am J Clin Pathol 1993; 99:741–745.

    PubMed  CAS  Google Scholar 

  8. Silverberg SG, Kurman RJ: Tumors of the uterine corpus and gestational trophoblastic disease. Atlas of Tumor Pathology, 3rd series, Fascicle 3. Washington, DC: Armed Forces Institute of Pathology, 1992.

    Google Scholar 

  9. Reeves G, Sommers SC: Endometrial hemosiderin as evidence of metrorrhagia. Obstet Gynecol 1962;19:790–792.

    PubMed  CAS  Google Scholar 

  10. Fechner RE, Bossart MI, Spjut HJ: Ultrastructure of endometrial stromal foam cells. Am J Clin Pathol 1979;72:628–633.

    PubMed  CAS  Google Scholar 

  11. Altchek A: Dysfunctional uterine bleeding in adolescence. Clin Obstet Gynecol 1977;20:633–650.

    Article  PubMed  CAS  Google Scholar 

  12. Scommegna A, Dmowski WP: Dysfunctional uterine bleeding. Clin Obstet Gynecol 1973; 16:221–254.

    Article  PubMed  CAS  Google Scholar 

  13. Aksel S, Jones GS: Etiology and treatment of dysfunctional uterine bleeding. J Obstet Gynecol 1974;44:1–13.

    CAS  Google Scholar 

  14. Rubin SC: Postmenopausal bleeding: Etiology, evaluation, and management. Med Clin N Am 1987;71:59–69.

    PubMed  CAS  Google Scholar 

  15. Schindler AE, Schmidt G: Post-menopausal bleeding: A study of more than 1000 cases. Maturitas 1980;2:269–274.

    Article  PubMed  CAS  Google Scholar 

  16. Choo YC, Mak KC, Hsu C, Wong TS, Ma HK: Postmenopausal uterine bleeding of nonorganic cause. Obstet Gynecol 1985;66:225–228.

    PubMed  CAS  Google Scholar 

  17. Meyer WC, Malkasian GD, Dockery MB, Decker DG: Postmenopausal bleeding from atrophic endometrium. Obstet Gynecol 1971; 38:731–738.

    PubMed  CAS  Google Scholar 

  18. Gambrell RD: Postmenopausal bleeding. J Am Geriatr Soc 1974;22:337–343.

    PubMed  Google Scholar 

  19. Lidor A, Ismajovich B, Confino E, David MP: Histopathological findings in 226 women with post-menopausal uterine bleeding. Acta Obstet Gynecol Scand 1983;65:41–43.

    Article  Google Scholar 

  20. Kurman RJ, Mazur MT: Benign diseases of the endometrium. In: Blaustein’s Pathology of the Female Genital Tract. 4th ed. Kurman RJ, ed. New York: Springer-Verlag, 1994;367–409.

    Chapter  Google Scholar 

  21. Dallenbach-Hellweg G: The endometrium of infertility. A review. Pathol Res Pract 1984; 78:527–537.

    Article  Google Scholar 

  22. Dallenbach-Hellweg G: Histopathology of the Endometrium. 4th ed. New York: Springer-Verlag, 1987.

    Book  Google Scholar 

  23. Hendrickson MR, Kempson RL: Surgical Pathology of the Uterine Corpus (Major Problems in Pathology Series). Volume 12. Philadelphia: W.B. Saunders, 1980.

    Google Scholar 

  24. Buckley CH, Fox H: Biopsy Pathology of the Endometrium. New York: Raven Press, 1989;234–247.

    Google Scholar 

  25. Good RG, Moyer DL: Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:37–45.

    PubMed  CAS  Google Scholar 

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Mazur, M.T., Kurman, R.J. (1995). Dysfunctional Uterine Bleeding. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3943-5_5

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  • DOI: https://doi.org/10.1007/978-1-4757-3943-5_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3945-9

  • Online ISBN: 978-1-4757-3943-5

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