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Gestational Trophoblastic Disease

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Diagnosis of Endometrial Biopsies and Curettings

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Abstract

Gestational trophoblastic disease (GTD) includes disorders of placental development (hydatidiform mole) and neoplasms of the trophoblast [choriocarcinoma and placental site trophoblastic tumor (PSTT)].1,2 The recent classification of these lesions by the World Health Organization (WHO) clearly defines the different histologic forms of GTD (Table 4.1).3 A common feature of all of these trophoblastic lesions is that they produce human chorionic gonadotropin (hCG), which serves as a marker for the presence of persistent or progressive trophoblastic tissue. Because these lesions are often treated in the absence of a histologic diagnosis, they are clinically classified as GTD without designation of the morphologic subtype. Nonetheless, identification and separation of the different pathologic forms of the disease are important, since they have different clinical presentations and behavior.

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Author information

Authors and Affiliations

  1. Crouse Irving Memorial Hospital, Health Science Center, State University of New York, Syracuse, NY, 13210, USA

    Michael T. Mazur M.D.

  2. Departments of Gynecology and Obstetrics and Pathology, The Johns Hopkins Hospital, Baltimore, MD, 21287, USA

    Robert J. Kurman M.D.

  3. The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA

    Robert J. Kurman M.D.

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  1. Michael T. Mazur M.D.
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Mazur, M.T., Kurman, R.J. (1995). Gestational Trophoblastic Disease. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3943-5_4

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  • DOI: https://doi.org/10.1007/978-1-4757-3943-5_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3945-9

  • Online ISBN: 978-1-4757-3943-5

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