Gestational Trophoblastic Disease

  • Michael T. Mazur
  • Robert J. Kurman


Gestational trophoblastic disease (GTD) includes disorders of placental development (hydatidiform mole) and neoplasms of the trophoblast [choriocarcinoma and placental site trophoblastic tumor (PSTT)].1,2 The recent classification of these lesions by the World Health Organization (WHO) clearly defines the different histologic forms of GTD (Table 4.1).3 A common feature of all of these trophoblastic lesions is that they produce human chorionic gonadotropin (hCG), which serves as a marker for the presence of persistent or progressive trophoblastic tissue. Because these lesions are often treated in the absence of a histologic diagnosis, they are clinically classified as GTD without designation of the morphologic subtype. Nonetheless, identification and separation of the different pathologic forms of the disease are important, since they have different clinical presentations and behavior.


Hydatidiform Mole Gestational Trophoblastic Disease Trophoblastic Tumor Complete Hydatidiform Mole Form Mole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Michael T. Mazur
    • 1
  • Robert J. Kurman
    • 2
    • 3
  1. 1.Crouse Irving Memorial Hospital, Health Science CenterState University of New YorkSyracuseUSA
  2. 2.Departments of Gynecology and Obstetrics and PathologyThe Johns Hopkins HospitalBaltimoreUSA
  3. 3.The Johns Hopkins University School of MedicineBaltimoreUSA

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