Transplantation Pathology

  • Dean W. Chamberlain


Serious consideration of lung transplantation as a treatment option for various forms of advanced pulmonary disease began with the first human lung transplant which was performed by Dr. James Hardy in 1963.1 However, there was little subsequent clinical success in this area until cyclosporin became available in 1981. Thirty-eight lung transplants had been carried out worldwide up to 1980, with only 2 patients surviving more than 1 month; the median survival was 8.5 days.2,3 Death usually occurred as a result of infection, complications in relation to the airway anastomosis, or rejection.


Major Histocompatibility Complex Class Acute Rejection Lung Transplant Chronic Rejection Bronchiolitis Obliterans 
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© Springer Science+Business Media New York 1994

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  • Dean W. Chamberlain

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