Tissue Sampling

  • David H. Dail


The continuous development of new clinical, radio-logic, surgical, and pathologic techniques highlights an ever-changing practice of pathology. With reference to many locations in the body, and certainly in the lung, the pathologist is being asked to be more diagnostic with smaller and smaller samples. Immunohistochemistry, DNA probes, polymerase chain reactions, and other newer techniques entering diagnostic practice may lead to a diagnosis based on only a few cells. As in electron microscopy, the challenge will be to judge whether such samples are truly representative and whether the changes observed account for the patient’s disease. Pattern recognition on tissue sections is still valuable (see Chapter 4), but is being supplemented and in part replaced with some of these newer techniques.


Lung Biopsy Pulmonary Infiltrate Bronchial Artery Fiberoptic Bronchoscopy Bronchial Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Klassen KP, Anlyan AJ, Curtis GM. Biopsy of diffuse pulmonary lesions. Arch Surg 1949; 59: 694–704.PubMedCrossRefGoogle Scholar
  2. 2.
    Chamberlain JM. Discussion of presentation on “mediastinoscopy.” J Thorac Cardiovasc Surg 1965; 49: 20.Google Scholar
  3. 3.
    McNeill TM, Chamberlain JM. Diagnostic anterior mediastinotomy. Ann Thorac Surg 1966; 2: 532–539.PubMedCrossRefGoogle Scholar
  4. 4.
    Andersen HA, Fontana RS, Harrison EG, Jr. Transbronchoscopic lung biopsy in diffuse pulmonary disease. Dis Chest 1965; 48: 187–192.PubMedCrossRefGoogle Scholar
  5. 5.
    Andersen HA, Fontana RS. Transbronchoscopic lung biopsy for diffuse pulmonary diseases: Techniques and results in 450 cases. Chest 1972; 62: 125–128.PubMedCrossRefGoogle Scholar
  6. 6.
    Anderson H. Transbronchial lung biopsy for diffuse pulmonary diseases. Results in 939 patients. Chest 1978; 73: 734–736.Google Scholar
  7. 7.
    Prakash VBS, Stubbs SE. The bronchoscopy survey: Some reflections. Chest 1991; 100: 1660–1667.PubMedCrossRefGoogle Scholar
  8. 8.
    Prakash VBS, Offord KP, Stubbs SE. Bronchoscopy in North America: The ACCP Survey. Chest 1991; 100: 1668–1675.PubMedCrossRefGoogle Scholar
  9. 9.
    Ikeda S. Flexible bronchofiber scope. Ann Otol Rhinol Laryngol 1970; 79: 916–923.PubMedGoogle Scholar
  10. 10.
    Kovnat DM, Rath GS, Anderson WM, Snider GL. Maximal extent of visualization of bronchial tree by flexible fiberoptic bronchoscopy. Am Rev Respir Dis 1974; 110: 88–90.PubMedGoogle Scholar
  11. 11.
    Herf SM, Suratt PM, Arora NS. Deaths and complications associated with transbronchial lung biopsy. Am Rev Respir Dis 1977; 115: 708–711.PubMedGoogle Scholar
  12. 12.
    Zavala DC. Pulmonary hemorrhage in fiberoptic trans-bronchial biopsy. Chest 1976; 70: 584–588.PubMedCrossRefGoogle Scholar
  13. 13.
    Silverman I. A new biopsy needle. Am J Surg 1938; 40: 671–672.CrossRefGoogle Scholar
  14. 14.
    Gaensler EA. Open and closed lung biopsy. In: Sackner MA, ed. Diagnostic techniques in pulmonary disease. Part II. New York: Marcel-Dekker, 1980: 579– 615.Google Scholar
  15. 15.
    Wang KP, Terry P, Marsh B. Bronchoscopic needle aspiration of paratracheal tumors. Am Rev Respir Dis 1978; 118: 17–21.PubMedGoogle Scholar
  16. 16.
    Wang KP, Marsh BR, Summer WR, Perry PB, Erozan YS, Baker RR. Transbronchial aspiration for diagnosis of lung cancer. Chest 1981; 80: 48–50.PubMedCrossRefGoogle Scholar
  17. 17.
    Wang KP, Kaponik EF, Briff EJ, Khouri N, Erozan Y. Transbronchial needle aspiration of peripheral pulmonary nodular. Chest 1984; 86: 819–823.PubMedCrossRefGoogle Scholar
  18. 18.
    Shure D, Fedullo PF. Transbronchial needle aspiration in the diagnosis of submucosal and peribronchial bronchogenic carcinoma. Chest 1985; 88: 49–51.PubMedCrossRefGoogle Scholar
  19. 19.
    Bartlett JG, Alexander J, Mayhew J, Sullivan-Sigler N, Gorbach SL. Should fiberoptic bronchoscopy aspirates be cultured? Am Rev Respir Dis 1976; 114: 73–78.PubMedGoogle Scholar
  20. 20.
    Winterbauer RH, Hutchinson JF, Reinhardt GN, et al. The use of quantitative cultures and antibody coating of bacteria to diagnose bacterial pneumonia by fiberoptic bronchoscopy. Am Rev Respir Dis 1983; 128: 98–103.PubMedGoogle Scholar
  21. 21.
    Carrington CB, Gaensler EA. Clinical-pathologic approach to diffuse infiltrative lung disease. In: Thurlbeck W, Abell M, eds. The lung: structure and function. Baltimore: Williams & Wilkins, 1978: 58 –87.Google Scholar
  22. 22.
    Gaensler EA, Carrington CB. Open lung biopsy for chronic diffuse infiltrative lung disease: clinical, roentgenographic and physiological correlations in 502 patients. Ann Thorac Surg 1980; 30: 411 –426.PubMedCrossRefGoogle Scholar
  23. 23.
    Churg A. An inflation procedure for open lung biopsies. Am J Surg Pathol 1983; 7: 69–71.PubMedCrossRefGoogle Scholar
  24. 24.
    Churg A. Lung biopsy: Handling and diagnostic limitations. In: Thurlbeck WM, ed. Pathology of the lung. Stuttgart: Thieme, 1988: 67–78.Google Scholar
  25. 25.
    Miller RR, Nelems B. Gross examination of lung resection specimens. In: Thurlbeck WM, ed. Pathology of the lung. Stuttgart: Thieme, 1988: 79–93.Google Scholar
  26. 26.
    Thurlbeck WM. Examination of the lung: Autopsy. In: Thurlbeck WM, ed. Pathology of the lung. Stuttgart: Thieme, 1988: 95–100.Google Scholar
  27. 27.
    Katzenstein A-L A, Askin FB. Surgical pathology of non-neoplastic lung disease. 2d Ed. Philadelphia: WB Saunders, 1990: 1–8.Google Scholar
  28. 28.
    Gaensler EA, Ball-Moister M, Hamm J. Open lung biopsy in diffuse pulmonary disease. N Engl J Med 1964; 270: 1319–1331.PubMedCrossRefGoogle Scholar
  29. 29.
    Gaensler EA, Carrington CB. Open biopsy for diffuse infiltrative lung disease. Ann Thorac Surg 1980; 40: 411–426.CrossRefGoogle Scholar
  30. 30.
    Greenman RL, Goodall PT, King D. Lung biopsy in immunocompromised hosts. Am J Med 1975; 59: 488496.Google Scholar
  31. 31.
    McLoud TC, Naidich DP. Thoracic diseases in the immunocompromised patient. Radiol Clin North Am 1992; 30: 525–554.PubMedGoogle Scholar
  32. 32.
    Kovacs JA, Hiemenz JW, Macher AM, et al. Pneumonocystis carinii pneumonia: A comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med 1984; 100: 663–671.PubMedCrossRefGoogle Scholar
  33. 33.
    Limper AH, Offord KP, Smith TF, Martin WJ, II. Pneumonocystis carinii pneumonia: Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis 1989; 140: 1204–1209.PubMedCrossRefGoogle Scholar
  34. 34.
    Sepkowitz KA, Brown AE, Telzak ED, Gottlieb S, Armstrong D. Pneumonocystis carinii pneumonia among patients without AIDS at a cancer hospital. JAMA 1992; 267: 832–837.PubMedCrossRefGoogle Scholar
  35. 35.
    Luna MA, Cleary KR. Spectrum of pathologic manifestations of Pneumonocystis carinii pneumonia in patients with neoplastic diseases. Semin Diagn Pathol 1989; 6: 262–272.PubMedGoogle Scholar
  36. 36.
    Raviglione MC. Extrapulmonary pneumocystosis: The first 50 cases. Rev Infect Dis 1990; 12: 1127–1138.PubMedCrossRefGoogle Scholar
  37. 37.
    Pennington JE, Feldman NT. Pulmonary infiltrates and fever in patients with hematologic malignancy. Am J Med 1977; 62: 581–587.PubMedCrossRefGoogle Scholar
  38. 38.
    Bodey GP, Powell RD, Hersh EM, Yeterian A, Freireich EJ. Pulmonary complications of acute leukemia. Cancer (Philadelphia) 1966; 19: 781–793.CrossRefGoogle Scholar
  39. 39.
    Bode FR, Pare JAP, Fraser RG. Pulmonary diseases in the compromised host. Medicine (Baltimore) 1974; 53: 255–293.Google Scholar
  40. 40.
    Feldman NT, Pennington JE, Ehrie MG. Transbronchial lung biopsy in the compromised host. JAMA 1977; 238: 1377–1379.PubMedCrossRefGoogle Scholar
  41. 41.
    Sickles EA, Young VM, Greene WH, Wiernik PH. Pneumonia in acute leukemia. Ann Intern Med 1973; 79: 528534.Google Scholar
  42. 42.
    Sickles EA, Greene WH, Wicknik PM. Clinical presentation of infection in granulocytopenic patients. Arch Intern Med 1975; 135: 715–719.PubMedCrossRefGoogle Scholar
  43. 43.
    Masur H, Shelhamer J, Parillo JE. The management of pneumonias in immunocompromised patients. JAMA 1985; 253: 1769–1773.PubMedCrossRefGoogle Scholar
  44. 44.
    Jaffee JP, Maki DG. Lung biopsy in immunocompromised patients: one institution’s experience and an approach to management of pulmonary disease in the compromised host. Cancer (Philadelphia) 1981; 48: 1144–1153.CrossRefGoogle Scholar
  45. 45.
    Hiatt JR, Gong H, Mulder DG, Ramming KP. The value of open lung biopsy in the immunosuppressed patient. Surgery 1982; 92: 285–291.PubMedGoogle Scholar
  46. 46.
    McCabe RE, Brooks RG, Mark JBD, Remington JS. Open lung biopsy in patients with acute leukemia. Am J Med 1985; 78: 609–616.PubMedCrossRefGoogle Scholar
  47. 47.
    Rosenow EC, III, Wilson WR, Cockerill FR III. Pulmonary disease in the immunocompromised host. Mayo Clin Proc 1985; 60: 473–487.PubMedCrossRefGoogle Scholar
  48. 48.
    Wilson WR, Cockerill FR, III, Rosenow EC III. Pulmonary disease in the immunocompromised host. Mayo Clin Proc 1985; 60: 610–631.PubMedCrossRefGoogle Scholar
  49. 49.
    Rosenow EC, III. The spectrum of drug-induced pulmonary disease. Ann Intern Med 1972; 77: 977–991.PubMedCrossRefGoogle Scholar
  50. 50.
    Sostman HD, Matthay RA, Putman CE. Cytotoxic drug-induced lung disease. Am J Med 1977; 62: 608–614.PubMedCrossRefGoogle Scholar
  51. 51.
    Demeter SL, Ahmad M, Tomashefski JF. Drug-induced pulmonary disease. Cleve Clin Q 1979; 46: 89–124.PubMedGoogle Scholar
  52. 52.
    Weiss RB, Muggia FM. Cytotoxic drug-induced pulmonary disease: Update 1980. Am J Med 1980; 68: 259266.Google Scholar
  53. 53.
    Cooper JAD Jr, White DA, Matthay RA. Drug-induced pulmonary disease. Am Rev Respir Dis 1986; 133: 321340, 488–505.PubMedGoogle Scholar
  54. 54.
    Jennings FL, Arden A. Development of radiation pneumonitis: time and dose factors. Arch Pathol Lab Med 1962; 74: 351–360.Google Scholar
  55. 55.
    Gross NJ. Pulmonary effect of radiation therapy. Ann Intern Med 1977; 86: 81–92.PubMedCrossRefGoogle Scholar
  56. 56.
    Williams DM, Krick JA, Remington JS. Pulmonary infection in the compromised host. Am Rev Respir Dis 1976;114: 359–394, 593–627.Google Scholar
  57. 57.
    Levin DC, Wicks AB, Ellis JH, Jr. Transbronchial lung biopsy via the fiberoptic bronchoscope. Am Rev Respir Dis 1974; 110: 4–12.PubMedGoogle Scholar
  58. 58.
    Ellis JH. Transbronchial lung biopsy via the fiberoptic bronchoscope. Experience with 107 consecutive cases and comparison with bronchial brushing. Chest 1975; 68: 524–532.PubMedCrossRefGoogle Scholar
  59. 59.
    Hanson RR, Zavala DC, Rhodes ML, Keim LW. Trans-bronchial biopsy via flexible fiberoptic bronchoscope: Results in 164 patients. Am Rev Respir Dis 1976; 114: 67–72.PubMedGoogle Scholar
  60. 60.
    Matthay RA, Farmer WC, Odero D. Diagnostic fiberoptic bronchoscopy in the immunosuppressed host with pulmonary infiltrates. Thorax 1977; 32: 539–545.PubMedCrossRefGoogle Scholar
  61. 61.
    Cunningham JH, Zavala DC, Corry RJ, Keim LW. Trephine air drill, bronchial brush and fiberoptic trans-bronchial lung biopsies in immunosuppressed patients. Am Rev Respir Dis 1977; 115: 213–220.PubMedGoogle Scholar
  62. 62.
    Feldman NT, Pennington JE, Ehrie MG. Transbronchial lung biopsy in the compromised host. JAMA 1977; 283: 1377–1379.CrossRefGoogle Scholar
  63. 63.
    Lauver GL, Hasan FM, Morgan RB, Campbell SC. The usefulness of fiberoptic bronchoscopy in evaluating new pulmonary lesions in the compromised host. Am J Med 1979; 66: 580–585.PubMedCrossRefGoogle Scholar
  64. 64.
    Poe RH, Utell MJ, Israel RH, Hall WJ, Eshleman JD. Sensitivity and specificity of the nonspecific transbronchial lung biopsy. Am Rev Respir Dis 1979; 119: 25–31.PubMedGoogle Scholar
  65. 65.
    Phillips MJ, Knight RK, Green M. Fiberoptic bronchoscopy and diagnosis of pulmonary lesions in lymphoma and leukemia. Thorax 1980; 35: 19–25.PubMedCrossRefGoogle Scholar
  66. 66.
    Chopra SK, Mohsenifar Z. Fiberoptic bronchoscopy in diagnosis of opportunistic infections-assessment of sputa, washings, brushings and biopsy specimens. West J Med 1979; 131: 4–7.PubMedGoogle Scholar
  67. 67.
    Katzenstein A-L A, Askin FB. Interpretation and significance of pathologic findings in transbronchial lung biopsy. Am J Surg Pathol 1980; 4: 223–234.PubMedCrossRefGoogle Scholar
  68. 68.
    Puska S, Hutcheon MA, Hyland RH. Usefulness of transbronchial biopsy in immunosuppressed patients with pulmonary infiltrates. Thorax 1983; 38: 146–250.CrossRefGoogle Scholar
  69. 69.
    Williams B, Yungbluth M, Adams G, Glassroth J. The role of fiberoptic bronchoscopy in the evaluation of the immunocompromised hosts with diffuse pulmonary infiltrates. Am Rev Respir Dis 1985; 131: 880–885.PubMedGoogle Scholar
  70. 70.
    Fechner RE, Greenberg SD, Wilson RK, Stevens PM. Evaluation of transbronchial biopsy of the lung. Am J Clin Pathol 1977; 68: 17–20.PubMedGoogle Scholar
  71. 71.
    Roback SA, Weintraub WH, Nesbit M, Spanos PK, Burke B, Leonard AS. Diagnostic open lung biopsy in the critically ill child. Pediatrics 1973; 52: 605–608.PubMedGoogle Scholar
  72. 72.
    Rosen PP, Martini N, Armstrong D. Pneumocystis carinii pneumonia: Diagnosis by lung biopsy. Am J Med 1975; 58: 794–802.PubMedCrossRefGoogle Scholar
  73. 73.
    Nelems JM, Cooper JD, Henderson RD, Peng T, Phillips MJ. Emergency open lung biopsy. Ann Thorac Surg 1976; 22: 260–263.PubMedCrossRefGoogle Scholar
  74. 74.
    Pennington JE, Feldman NT. Pulmonary infiltrates and fever in patients with hematologic malignancy: Assessment of transbronchial biopsy. Am J Med 1977; 62: 58 1587.Google Scholar
  75. 75.
    Wolff LJ, Bartlett M, Baehner RL, Grosfeld JL, Smith JW. The causes of interstitial pneumonia in immunocompromised children. An aggressive systemic opproach to diagnosis. Pediatrics 1977; 60: 41–45.PubMedGoogle Scholar
  76. 76.
    Leight GS Jr, Michaelis LL. Open lung biopsy for the diagnosis of acute, diffuse pulmonary infiltrates in the immunosuppressed patient. Chest 1978; 73: 477–482.PubMedCrossRefGoogle Scholar
  77. 77.
    Singer C, Armstrong D, Rosen PP, Walzer PD, Yu B. Diffuse pulmonary infiltrates immunosuppressed patients: Prospective study of 80 cases. Am J Med 1979; 66: 110–120.PubMedCrossRefGoogle Scholar
  78. 78.
    Rossiter SJ, Miller C, Churg AM, Carrington CB, Mark JBD. Open lung biopsy in the immunosuppressed patient: Is it really beneficial? J Thorac Cardiovasc Surg 1979; 77: 338–345.PubMedGoogle Scholar
  79. 79.
    Toledo-Pereyra LH, DeMeester TR, Kinealey A, Mac-Mahon H, Churg A, Golomb H. The benefits of open lung biopsy in patients with previous nondiagnostic transbronchial lung biopsy: A guide to appropriate therapy. Chest 1980; 77: 647–650.PubMedCrossRefGoogle Scholar
  80. 80.
    Tenholder MF, Hooper RG. Pulmonary infiltrates in leukemia. Chest 1980; 78: 468–473.PubMedCrossRefGoogle Scholar
  81. 81.
    Waltzer WC, Sterioff S, Zincke H, Bernetz PE, Brewer NS. Open lung biopsy in the renal transplant recipient. Surgery 1980; 88: 601–610.PubMedGoogle Scholar
  82. 82.
    Canham EM, Kennedy TC, Merrick TA. Unexplained pulmonary infiltrates in the compromised patient: An invasive investigation in a consecutive series. Cancer (Philadelphia) 1983; 52: 325–329.CrossRefGoogle Scholar
  83. 83.
    McKenna RJ, Jr, Mountain CF, McMurtry MJ. Open lung biopsy in immunocompromised patients. Chest 1984; 86: 671–674.PubMedCrossRefGoogle Scholar
  84. 84.
    Prober CG, Whyte H, Smith CR. Open lung biopsy in immunocompromised children with pulmonary infiltrates. Am J Dis Child 1984; 138: 60–63.PubMedGoogle Scholar
  85. 85.
    Cockerill FR, III, Wilson WR, Carpenter HA, Smith TF, Rosenow EC, III. Open lung biopsy in immunocompromised patients. Arch Intern Med 1985; 145: 1398–1404.PubMedCrossRefGoogle Scholar
  86. 86.
    Neff TA. Lung biopsy: How vs. whom? Chest 1976; 70: 201–202.CrossRefGoogle Scholar
  87. 87.
    Webster J, Clarke J. A doctor’s dilemma-1980. Chest 1980; 78: 417–418.PubMedCrossRefGoogle Scholar
  88. 88.
    Wardman AG, Cooke NJ. Pulmonary infiltrates in adult acute leukemia: Empirical treatment or lung biopsy. Thorax 1984; 35: 647–650.CrossRefGoogle Scholar
  89. 89.
    Reuben DB. Learning diagnostic restraint. N Engl J Med 1984; 310: 591–595.PubMedCrossRefGoogle Scholar
  90. 90.
    Robin ED, Burke CM. Lung biopsy in immunosuppressed patients. Chest 1986; 89: 276–278.PubMedCrossRefGoogle Scholar
  91. 91.
    Wilson RK, Fechner RE, Greenberg SD, Estrada R, Stevens PM. Clinical implications of a nonspecific trans-bronchial biopsy. Am J Med 1978; 65: 252–256.PubMedCrossRefGoogle Scholar
  92. 92.
    Ray JF, III, Lawton BR, Myers WO, et al. Open pulmonary biopsy: 19 years experience with 416 consecutive operations. Chest 1976; 69: 43–47.PubMedCrossRefGoogle Scholar
  93. 93.
    Wall CP, Gaensler EA, Carrington CB, Hayes JA. Comparison of transbronchial and open lung biopsies in chronic infiltrative-lung diseases. Am Rev Respir Dis 1981; 123: 280–285.PubMedGoogle Scholar
  94. 94.
    Buechner HA. Differential diagnosis of miliary diseases of lung. Med Clin North Am 1959; 43: 89–112.PubMedGoogle Scholar
  95. 95.
    Epler GR, McLoud TC, Gaensler EA, Mikus JP, Car rington CB. Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med 1978; 298: 934–939.PubMedCrossRefGoogle Scholar
  96. 96.
    Scadding JG. Lung biopsy in the diagnosis of diffuse lung disease. Br Med J 1970; 2: 557–564.PubMedCrossRefGoogle Scholar
  97. 97.
    Zavala DC. Diagnostic fiberoptic bronchoscopy: Techniques and results of biopsy in 600 patients. Chest 1975; 68: 12–19.PubMedCrossRefGoogle Scholar
  98. 98.
    Koerner SK, Sakowitz AJ, Appelman RI, et al. Trans-bronchial lung biopsy for the diagnosis of sarcoidosis. N Engl J Med 1975; 293: 268–270.PubMedCrossRefGoogle Scholar
  99. 99.
    Poe RH, Israel RH, Utell MJ, Hall WJ. Probability of a positive transbronchial lung biopsy result in sarcoidosis. Arch Intern Med 1979; 139: 761–763.PubMedCrossRefGoogle Scholar
  100. 100.
    Koontz CH, Joyner LR, Nelson RA. Transbronchial lung biopsy via the fiberoptic bronchoscope in sarcoidosis. Ann Intern Med 1976; 85: 64–66.CrossRefGoogle Scholar
  101. 101.
    Joyner LR, Schneinhorn DJ. Transbronchial forceps lung biopsy through the fiberoptic bronchoscope. Chest 1975; 67: 532–535.PubMedCrossRefGoogle Scholar
  102. 102.
    Smith CW, Murray GF, Wilcox BR. The role of trans-bronchial lung biopsy in diffuse pulmonary disease. Ann Thorac Surg 1977; 24: 54–58.PubMedCrossRefGoogle Scholar
  103. 103.
    ILO U/C. 1971 International classification of radiographs of the pneumoconioses. Med Radiogr Photogr 1972; 48: 67–76.Google Scholar
  104. 104.
    International Labour Office: Guidelines for the Use of ILO International Classification of Radiographs of Pneumoconioses. Geneva: International Labour Office, 1980.Google Scholar
  105. 105.
    McLoud TC, Gaensler EA, Carrington CB. Chronic diffuse infiltrative lung disease: Newer approaches. Clin Chest Med 1984; 5: 329–344.PubMedGoogle Scholar
  106. 106.
    Lemberskaya EY. Morphological changes in the areas of the lingual segment of the lung, biopsied during mitral commissurotomy. Arkh Patol 1967; 29: 20–23.Google Scholar
  107. 107.
    Vogt T, Fauser A, Schlosser V, et al. Patho-histological findings in lung biopsies in patients following mitral commissurotomy and morphometric examination of the upper and lower lobes of the lung. Bull Soc Int Chir 1975; 34: 147–151.PubMedGoogle Scholar
  108. 108.
    Newman SL, Michel RP, Wang NS. Lingular lung biopsy: Is it representative? Am Rev Respir Dis 1985; 132: 1084–1086.PubMedGoogle Scholar
  109. 109.
    Wetstein L. Sensitivity and specificity of lingular segmental biopsies of the lung. Chest 1986; 90: 383–386.PubMedCrossRefGoogle Scholar
  110. 110.
    Miller RR, Nelems B, Muller NL, et al. Lingular and right middle lobe biopsy in the assessment of diffuse lung disease. Ann Thorac Surg 1987; 44: 269–272.PubMedCrossRefGoogle Scholar
  111. 111.
    Klassen KP, Andrews NC. Biopsy of diffuse pulmonary lesions: a seventeen-year experience. Ann Thorac Surg 1967; 4: 117–124.PubMedCrossRefGoogle Scholar
  112. 112.
    Ulbright TM, Katzenstein A-L A. Solitary necrotizing granulomas of the lung: Differentiating features and etiology. Am J Surg Pathol 1980; 4: 13–28.PubMedGoogle Scholar
  113. 113.
    Askin FB, Katzenstein AA. Pneumocystis infection masquerading as diffuse alveolar damage: a potential source of diagnostic error. Chest 1981; 79: 420–422.PubMedCrossRefGoogle Scholar
  114. 114.
    Narat JK, Loef JA, Narat M. On the preparation of multicolored corrosion specimens. Anat Rec 1936; 64: 155–160.CrossRefGoogle Scholar
  115. 115.
    Tompsett DH. Anatomical techniques. 2d Ed. Edinburgh: Livingstone, 1970.Google Scholar
  116. 116.
    Heard BE. A pathological study of emphysema of the lungs with chronic bronchitis. Thorax 1958; 13: 136149.Google Scholar
  117. 117.
    Pratt PC. Preparation of normal and emphysematous lung tissue for structural study of bronchioles, alveolar ducts, and alveoli. Am Rev Tuberc 1959; 79: 842–843.Google Scholar
  118. 118.
    Heard BE. Pathology of pulmonary emphysema: methods of study. Am Rev Respir Dis 196Q; 82: 792–799.Google Scholar
  119. 119.
    Heard BE, Esterly JR, Wootliff JS. A modified apparatus for fixing lungs to study the pathology of emphysema. Am Rev Respir Dis 1967; 95: 311–312.PubMedGoogle Scholar
  120. 120.
    Sils B. A multidisciplinary method for study of lung structure and function. Am Rev Respir Dis 1962; 86: 238–245.Google Scholar
  121. 121.
    Markarian B. A simple method of inflation-fixation and air-drying of lungs. Am J Clin Pathol 1975; 63: 20–24.PubMedGoogle Scholar
  122. 122.
    Heitzman ER. The lung: radiologic-pathologic correlations. 2d Ed. St. Louis: Mosby, 1984.Google Scholar
  123. 123.
    Pratt PC, Klugh ‘GA. A technique for the study of ventilatory capacity, compliance, and residual volume of excised lungs and for fixation, drying, and serial sectioning in the inflated state. Am Rev Respir Dis 1961; 83: 690–696.PubMedGoogle Scholar
  124. 124.
    Gough J, Wentworth JE. The use of thin sections of entire organs in morbid anatomical studies. J R Microsc Soc 1949; 69: 231–235.CrossRefGoogle Scholar
  125. 125.
    Gough J. Diseases of the lung. In: Harrison CV, ed. Recent advances in pathology. Vol 7. London: Churchill, 1960: 54–86.Google Scholar
  126. 126.
    Whimster WF. Rapid giant paper sections of lungs. Thorax 1969; 24: 737–741.PubMedCrossRefGoogle Scholar
  127. 127.
    Whimster WF. Techniques for the examination of excised lungs. Hum Pathol 1970; 1: 305–314.PubMedCrossRefGoogle Scholar
  128. 128.
    Timbrell V, Bevan NE, Davies AS, Munday DE. Hollow casts of lungs for experimental purposes. Nature (London) 1970; 225: 97–98.CrossRefGoogle Scholar
  129. 129.
    Eisman MM. Lung models: hollow, flexible reproductions. J Appl Physiol 1970; 29: 531–533.PubMedGoogle Scholar
  130. 130.
    Kilpper RW, Stidd PJ. A wet lung technique for obtaining silastic rubber casts of the respiratory airways. Anat Rec 1973; 176: 279–288.PubMedCrossRefGoogle Scholar
  131. 131.
    Wang NS, Ying WC. A scanning electron microscopic study of alkali-digested human and rabbit alveoli. Am Rev Respir Dis 1977; 115: 449–460.PubMedGoogle Scholar
  132. 132.
    Lauweryns JM. The blood and lymphatic microcirculation of the lung. Pathol Annu 1971; 6: 365–415.PubMedGoogle Scholar
  133. 133.
    Liebow AA, Hales MR, Lindskog GE, Bloomer WE. Plastic demonstrations of pulmonary pathology. Bull Int Assoc Med Museums 1947; 27: 116–129.Google Scholar
  134. 134.
    Moolten SE. A simple apparatus for fixation of lungs in the inflated state. Arch Pathol Lab Med 1935; 20: 77–80.Google Scholar
  135. 135.
    Hales MR, Carrington CB. A pigmented gelatin mass for vascular injection. Yale J Biol Med 1971; 43: 257–270.PubMedGoogle Scholar
  136. 136.
    Schlesinger MJ. New radiopaque mass for vascular injection. Lab Invest 1957; 6: 1–11.PubMedGoogle Scholar
  137. 137.
    Reynolds DG. Injection techniques in the study of intestinal vasculature under normal conditions and in ulcerative colitis. In: Boley SC, ed. Vascular disorders of the intestine. New York: Appleton-Century-Crofts, 1971: 383–395.Google Scholar
  138. 138.
    Mitsudo SM, Boley SJ, Brandt LJ, Montefusco CM, Sammartano RJ. Vascular ectasias of the right colon in the elderly: A distinct pathologic entity. Hum Pathol 1979; 10: 585–600.PubMedCrossRefGoogle Scholar
  139. 139.
    Case records of the Massachusetts General Hospital. Case 36–1974. N Engl J Med 1974; 291: 569–575.Google Scholar

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© Springer Science+Business Media New York 1994

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  • David H. Dail

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