Congenital and Developmental Diseases

  • J. Thomas Stocker


The pathology of infectious diseases of the lung is, for the most part, similar in adults and children. However, a number of other disorders either are seen almost exclusively in the pediatric age group (e.g., congenital anomalies) or occur in circumstances peculiar to this age group (e.g., hyaline membrane disease and bronchopulmonary dysplasia). Congenital anomalies of the lung are usually noted within the first weeks to months of life but may not be discovered until later in childhood or, in some cases such as bronchogenic cysts, until adulthood. A knowledge of the development of the lung is important in the understanding of the morphologic features of these anomalies.


Esophageal Atresia Pulmonary Hypoplasia Bronchogenic Cyst Tracheoesophageal Fistula Congenital Cystic Adenomatoid Malformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Inselman LS, Mellins RB. Growth and development of the lung. J Pediatr 1981; 98: 1–15.PubMedCrossRefGoogle Scholar
  2. 2.
    Hislop A, Reid L. Fetal and childhood development of the intra-pulmonary veins in man-branching pattern and structure. Thorax 1973; 28: 313–319.PubMedCrossRefGoogle Scholar
  3. 3.
    Hislop A, Reid L. Intrapulmonary arterial development during life-branching pattern and structure. J Anat 1972; 113: 35–48.PubMedGoogle Scholar
  4. 4.
    Kitterman JA. Fetal lung development. J Dev Physiol 1984; 6: 67–82.PubMedGoogle Scholar
  5. 5.
    Avery ME, Fletcher DB, William RG. The lung and its disorders in the newborn infant. 4th ed. Philadelphia: WB Saunders, 1981: 3–27.Google Scholar
  6. 6.
    Lauweryns JM. The blood and lymphatic microcirculation of the lung. Pathol Annu 1971; 6: 365–415.PubMedGoogle Scholar
  7. 7.
    Langston C, Thurlbeck WM. Lung growth and development in late gestation and early postnatal life. Perspect Pediatr Pathol 1982; 7: 203–235.PubMedGoogle Scholar
  8. 8.
    Langston C, Kida K, Reed M, Thurlbeck WM. Human lung growth in late gestation and in the neonate. Am Rev Respir Dis 1984; 129: 607–613.PubMedGoogle Scholar
  9. 9.
    Robertson B. The normal intrapulmonary arterial pattern of the human late fetal and neonatal lung. Acta Paediatr Scand 1967; 56: 349–364.CrossRefGoogle Scholar
  10. 10.
    Stocker JT, McGill LC, Orsini EN. Post-infarction peripheral cysts of the lung in pediatric patients: a possible cause of idiopathic spontaneous pneumothorax. Pediatr Pulmonol 1985; 1: 7–18.PubMedCrossRefGoogle Scholar
  11. 11.
    Payne WA. Congenital absence of the trachea. Brooklyn Med J 1900; 14: 568.Google Scholar
  12. 12.
    Effman EL, Spackman TJ, Berden WE, Kuhn JP, Leonidas JC. Tracheal agenesis. AJR 1975; 125: 767–781.CrossRefGoogle Scholar
  13. 13.
    Warfel KA, Schulz DM. Agenesis of the trachea. Arch Pathol Lab Med 1976; 100: 357–359.PubMedGoogle Scholar
  14. 14.
    Faro RS, Goodwin CD, Organ CH, et al. Tracheal agenesis. Ann Thorac Surg 1979; 28: 295–299.PubMedCrossRefGoogle Scholar
  15. 15.
    Milstein JM. Tracheal agenesis in infants with VATER association. Am J Dis Child 1985; 139: 77–80.PubMedGoogle Scholar
  16. 16.
    Milles G, Dorsey DB. Intra-uterine respiration-like movements in relation to development of the fetal vascular system. Am J Pathol 1950; 26: 411–425.PubMedGoogle Scholar
  17. 17.
    Eimer H. Aplasia of the trachea in a newborn. Zentralbl Gynaekol 1969; 91: 1614–1616.Google Scholar
  18. 18.
    Morison JE. Congenital malformations in one of mono-zygotic twins. Arch Dis Child 1949; 24: 214–218.PubMedCrossRefGoogle Scholar
  19. 19.
    Harrison MR, Heldt GP, Brusch RC, DeLorimer AA, Gregory GA. Resection of distal tracheal stenosis in a baby with agenesis of the lung. J Pediatr Surg 1980; 15: 938–943.PubMedCrossRefGoogle Scholar
  20. 20.
    Landing BH, Wells TR. Tracheobronchial anomalies in children. Perspect Pediatr Pathol 1973; 1: 1–32.PubMedGoogle Scholar
  21. 21.
    Berdon WE. Complete cartilage-ring tracheal stenosis associated with anomalous left pulmonary artery: The ring-sling complex. Radiology 1984; 152: 57–64.Google Scholar
  22. 22.
    Richardson MA, Cotton RT. Anatomic abnormalities of the pediatric airway. Pediatr Clin North Am 1984; 31: 821–834.PubMedGoogle Scholar
  23. 23.
    Nelson CS, McMillan IKR, Bharucha PK. Tracheal stenosis, pulmonary agenesis, and patent ductus arteriosis. Thorax 1967; 22: 7–12.CrossRefGoogle Scholar
  24. 24.
    Johner CH, Szanto PA. Polychondritis in a newborn presenting as tracheomalacia. Ann Otol Rhinol Laryngol 1970; 79: 1114–1116.PubMedGoogle Scholar
  25. 25.
    Seegmiller R, Fraser FC, Ferguson CC, Sheldon H. Studies on cartilage. VI. A genetically determined defect in tracheal cartilage. J Ultrastruct Res 1972; 38: 288–301.PubMedCrossRefGoogle Scholar
  26. 26.
    Katz I, Levine M, Herman P. Tracheobronchiomegaly: the Mounier-Kuhn syndrome. AJR 1962; 88: 1084 1094.Google Scholar
  27. 27.
    Wanderer AA, Ellis EF, Goltz RW, Cotton EK. Tracheobronchiomegaly and acquired cutis laxa in a child. Pediatrics, 1969; 44: 709–715.PubMedGoogle Scholar
  28. 28.
    Hunter TB, Kuhns LR, Roloff MA, Holt JF. Tracheobronchiomegaly in an 18-month-old-child. AJR 1975; 123: 687–690.CrossRefGoogle Scholar
  29. 29.
    Johnston RF, Green RA. Tracheobronchiomegaly: Report of 5 cases and demonstration of familial occurrence. Am Rev Respir Dis 1965; 91: 35–50.PubMedGoogle Scholar
  30. 30.
    Aaby GV, Blake HA. Tracheobronchiomegaly. Ann Thorac Surg 1966; 2: 64–70.PubMedCrossRefGoogle Scholar
  31. 31.
    Avery ME, Fletcher BD, Williams RG. The lung and its disorders in the newborn infant. 4th ed. Philadelphia: WB Saunders, 1981: 150–154.Google Scholar
  32. 32.
    Sankaran K, Bhagirath CP, Bingham WT, Hjertaas R, Haight K. Tracheal atresia, proximal esophageal atresia and distal tracheoesophageal fistula: report of two cases and review of literature. Pediatrics 1983; 71: 81–823.Google Scholar
  33. 33.
    Holder TM, Cloud DT, Lewis JE, Pilling GB. Esophageal atresia and tracheoesophageal fistula. Pediatrics 1964; 35: 542–549.Google Scholar
  34. 34.
    German JC, Mahour GH, Woolley MM. Esophageal atresia and associated anomalies. J Pediatr Surg 1976; 11: 299–306.PubMedCrossRefGoogle Scholar
  35. 35.
    Greenwood RD, Rosenthal A. Cardiovascular malformations associated with tracheoesophageal fistula and esophageal atresia. Pediatrics 1976; 57: 87–91.PubMedGoogle Scholar
  36. 36.
    Atwell JD, Beard RC. Congenital anomalies of the upper urinary tract associated with esophageal atresia and tracheoesophageal fistula. J Pediatr Surg 1974; 9: 825–831.PubMedCrossRefGoogle Scholar
  37. 37.
    Quan L, Smith DW. The VATER association, Vertebral defects, Anal atresia, T-E fistula with esophageal atresia, Radial and Renal dysplasia: a spectrum of associated defects. J Pediatr 1973; 82: 104–107.PubMedCrossRefGoogle Scholar
  38. 38.
    Temtamy SA, Miller JD. Extending the scope of the VATER association: definition of the VATER syndrome. J Pediatr 1974; 85: 345–349.PubMedCrossRefGoogle Scholar
  39. 39.
    Nora AH, Nora JJ. A syndrome of multiple congenital anomalies associated with teratogenic exposure. Arch Environ Health 1975; 30: 17–21.PubMedGoogle Scholar
  40. 40.
    Khoury MJ, Cordero JF, Greenberg F, James LM, Erickson JD. A population study of the VACTERL association: evidence for its etiologic heterogeneity. Pediatrics 1983; 71: 815–820.PubMedGoogle Scholar
  41. 41.
    Uehling DT, Gilbert E, Chesney R. Urologic implications of the VATER association. J Urol 1983; 129: 352–354.PubMedGoogle Scholar
  42. 42.
    Ein SH, Stringer DA, Stephens CA, Shandling B, Simpson J, Filler RM. Recurrent tracheoesophageal fistulas: seventeen-year review. J Pediatr Surg 1983; 18: 436 441.Google Scholar
  43. 43.
    Couriel JM, Hibbert M, Olinsky A, Phelan PD. Longterm pulmonary consequences of oesophageal atresia with tracheo-oesophageal fistula. Acta Paediatr Scand 1982; 71: 973–978.PubMedCrossRefGoogle Scholar
  44. 44.
    Becher RM, Lesperance R, Despas P, Wilson JAS. Congenital esophagobronchial fistula in a 62-year-old woman. Chest 1976; 69: 110–112.CrossRefGoogle Scholar
  45. 45.
    Emery JL, Haddadin AJ. Squamous epithelium in respiratory tract of children with tracheo-oesophageal fistula. Arch Dis Child 1971; 46: 236–242.PubMedCrossRefGoogle Scholar
  46. 46.
    Landing BH. Congenital malformations and genetic disorders of the respiratory tract. Am Rev Respir Dis 1979; 120: 151–185.PubMedGoogle Scholar
  47. 47.
    Atwell SW. Major anomalies of the tracheobronchial tree with a list of minor anomalies. Dis Chest 1967; 52: 611–615.PubMedCrossRefGoogle Scholar
  48. 48.
    McLaughlin FJ, Strieder DJ, Harris GBC, Vawter GP, Eraklis AJ. Tracheal bronchus: association with respiratory morbidity in childhood. J Pediatr 1985; 106: 751–755.PubMedCrossRefGoogle Scholar
  49. 49.
    Gonzalez-Crussi F, Padilla L, Miller JK, Grosfeld JL. “Bridging bronchus.” Am J Dis Child 1976; 130: 1015–1018.PubMedGoogle Scholar
  50. 50.
    Gleason IO, Tildon TT, Rosen VJ. Ectopic thyroid tissue causing bronchial obstruction. Ann Thorac Surg 1967; 3: 151–153.PubMedCrossRefGoogle Scholar
  51. 51.
    Patronas NJ, MacMahon H, Variakojis D. Bronchial web diagnosed by bronchiography. Radiology 1976; 121: 526.PubMedGoogle Scholar
  52. 52.
    Williams H, Campbell P. Generalized bronchiectasis associated with deficiency of cartilage in the bronchial tree. Arch Dis Child 1960; 35: 182–191.PubMedCrossRefGoogle Scholar
  53. 53.
    Mitchell RE, Bury RG. Congenital bronchiectasis due to deficiency of bronchial cartilage (Williams-Campbell syndrome). J Pediatr 1975; 87: 230–234.PubMedCrossRefGoogle Scholar
  54. 54.
    Davis PB, Hubbard VS, McCoy K, Taussig LM. Familial bronchiectasis. J Pediatr 1983; 102: 177–185.PubMedCrossRefGoogle Scholar
  55. 55.
    Oppenheimer EH. Similarity of the tracheobronchial mucous glands and epithelium in infants with and without cystic fibrosis. Hum Pathol 1981; 12: 36–48.PubMedCrossRefGoogle Scholar
  56. 56.
    Simel DL, Mastin JP, Pratt PC, et al. Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases. Pediatr Pathol 1984; 2: 47–64.PubMedCrossRefGoogle Scholar
  57. 57.
    Pysher TJ, Neustein HB. Ciliary dysmorphology. Perspect Pediatr Pathol 1984; 8: 101–131.PubMedGoogle Scholar
  58. 58.
    Turner JAP, Corkey CWB, Lee JYV, Levison H, Sturgess J. Clinical expressions of immotile cilia syndrome. Pediatrics 1981; 67: 805–810.PubMedGoogle Scholar
  59. 59.
    MacMahon HE, Ruggieri J. Congenital segmental bronchomalacia. Am J Dis Child 1969; 118: 923–926.PubMedGoogle Scholar
  60. 60.
    Chandra Mohan Cupta TG, Goldberg SJ, Lewis E, Fonkalsurd EW. Congenital bronchiomalacia. Am J Dis Child 1968; 115: 88–90.Google Scholar
  61. 61.
    Van Benthem LHBM, Driessin O, Haneveld GT, Rietema HP. Cryptorchidism, chest deformities and other congenital anomalies in three brothers. Arch Dis Child 1970; 45: 143–144.CrossRefGoogle Scholar
  62. 62.
    Sane SM, Steber WK, Girdany BR: Congenital bronchobiliary fistula. Surgery 1971; 69: 599–608.PubMedGoogle Scholar
  63. 63.
    Kalayoglu M, Olcay I. Congenital bronchiobiliary fistula associated with esophageal atresia and tracheo-esophageal fistula. J Pediatr Surg 1976; 11: 463–464.PubMedCrossRefGoogle Scholar
  64. 64.
    Chan YT, Ng WD, Mak WP, Kwong ML, Chow CB. Congenital bronchiobiliary fistula associated with ciliary atresia. Br J Surg 1984; 71: 240–241.PubMedCrossRefGoogle Scholar
  65. 65.
    Buntain WL, Isaacs H, Payne VC, Lindesmith GG, Rosenkrantz JG. Lobar emphysema, cystic adenomatoid malformation, pulmonary sequestration, and bronchogenic cyst in infancy and childhood: a clinical group. J Pediatr Surg 1974; 9: 85–93.PubMedCrossRefGoogle Scholar
  66. 66.
    Ramenofsky ML, Leape LL, McCauley RGK. Bronchogenic cyst. J Pediatr Surg 1979; 14: 219–224.PubMedCrossRefGoogle Scholar
  67. 67.
    Sirivella S, Ford WB, Zikria EA, Miller WH, Samadani SR, Sullivan ME. Foregut cysts of the mediastinum. J Thorac Cardiovasc Surg 1985; 90: 776–782.PubMedGoogle Scholar
  68. Katzenstein AA, Askin FB. Pediatric disorders. I. Congenital malformations. In: Surgical pathology of nonneoplastic lung disease. Philadelphia: WB Saunders, 1982:314–337.Google Scholar
  69. 69.
    Fraga S, Helwig EB, Rosen SH. Bronchogenic cysts in the skin and subcutaneous tissue. Am J Clin Pathol 1971; 56: 230–238.PubMedGoogle Scholar
  70. 70.
    Eraklis AJ, Griscom NT, McGovern JB. Bronchogenic cysts of the mediastinum in infancy. N Engl J Med 1969; 281: 1150–1155.PubMedCrossRefGoogle Scholar
  71. 71.
    Touloukian RJ. Air-filled bronchogenic cyst presenting as a cervical mass in the newborn. J Pediatr Surg 1982; 17: 311–312.PubMedCrossRefGoogle Scholar
  72. 72.
    Canty TG, Hendren WH: Upper airway obstruction from foregut cysts of the hypopharynx. J Pediatr Surg 1975; 10: 807–812.PubMedCrossRefGoogle Scholar
  73. 73.
    Alshakbhoun S, Starkey GWB, Asnes RA. Bronchogenic cysts of the mediastinum in infancy. Ann Thorac Surg 1967; 4: 532–541.CrossRefGoogle Scholar
  74. 74.
    Reed JC, Sobonya RE. Morphologic analysis of foregut cysts in the throax. AJR 1974; 120: 851–860.CrossRefGoogle Scholar
  75. 75.
    Aaron BL. Intradiaphragmatic cyst: a rare entity. J Thorac Cardiovasc Surg 1965; 49: 531–534.PubMedGoogle Scholar
  76. 76.
    Harmand D, Grosdidier J, Hoeffel JC. Multiple bronchogenic cysts of the esophagus. Am J Gastroenterol 1981; 75: 321–323.PubMedGoogle Scholar
  77. 77.
    Houser WC, Dorff GJ, Rosenweig DY, Aussem JW. Mycobacterial infection of a congenital bronchogenic cyst. Thorax 1980; 35: 312–313.PubMedCrossRefGoogle Scholar
  78. 78.
    Stocker JT, Kagan-Hallet K. Extralobar pulmonary sequestration: analysis of 15 cases. Am J Clin Pathol 1979; 72: 917–925.PubMedGoogle Scholar
  79. 79.
    Weichert RF, Lindsey ES, Pearce CW, Waring WW. Bronchogenic cyst with unilateral obstructive emphysema. J Thorac Cardiovasc Surg 1970; 59: 287–291.PubMedGoogle Scholar
  80. 80.
    Williams AJ, Schuster SR. Bronchial atresia associated with a bronchogenic cyst: evidence of early appearance of atretic segments. Chest 1985; 87: 396–398.PubMedCrossRefGoogle Scholar
  81. 81.
    Cipriano P, Sweeney LJ, Hutchins GM, Rosenquist GC. Horseshoe lung in an infant with recurrent pulmonary infections. Am J Dis Child 1975; 129: 1343–1345.PubMedGoogle Scholar
  82. 82.
    Orzem F, Angelini P, Oglietti J, Leachman RD, Cooley DA. Horseshoe lung: report of two cases. Am Heart J 1977; 93: 501–505.CrossRefGoogle Scholar
  83. 83.
    Dische MR. Horseshoe lung associated with a variant of the “scimitar” syndrome. Br Heart J 1974; 36: 617620.Google Scholar
  84. 84.
    Siegelman SS, Shanser JD, Attai LA. Cervical herniation of the lung associated with transient venous occlusions. Dis Chest 1968; 53: 785–787.PubMedGoogle Scholar
  85. 85.
    Chaurasia BD, Singh MP. Ectopic lungs in a human fetus with Klippel-Feil syndrome. Anat Anz 1977; 142: 205–208.PubMedGoogle Scholar
  86. 86.
    Chaurasia BD, Wagh KV. Iniencephalus with ectopic lungs. Anat Anz 1974; 136: 447–452.PubMedGoogle Scholar
  87. 87.
    Cunningham MD, Peters ER. Cervical hernia of the lung associated with cri du chat syndrome. Am J Dis Child 1969; 118: 769–771.PubMedGoogle Scholar
  88. 88.
    Ostor AG, Stillwell R, Fortune DW. Bilateral pulmonary agenesis. Pathology 1978; 10: 243–248.PubMedCrossRefGoogle Scholar
  89. 89.
    Devi B, More JRS. Total tracheopulmonary agenesis. Acta Paediatr Scand 1966; 55: 107–116.PubMedCrossRefGoogle Scholar
  90. 90.
    Claireaux AE, Ferreira HP. Bilateral pulmonary agenesis. Arch Dis Child 1958; 33: 364–366.PubMedCrossRefGoogle Scholar
  91. 91.
    Tuyman PE, Gardner LW. Bilateral aplasia of the lung. Arch Pathol Lab Med 1952; 54: 306–313.Google Scholar
  92. 92.
    Schechter DC. Congenital absence or deficiency of lung tissue. Ann Thorac Surg 1968; 6: 286–313.CrossRefGoogle Scholar
  93. 93.
    Mardini MK, Nyhan WL. Agenesis of the lung: report of four patients with unusual anomalies. Chest 1985; 87: 522–527.PubMedCrossRefGoogle Scholar
  94. 94.
    Booth JB, Berry CL. Unilateral pulmonary agenesis. Arch Dis Child 1967; 42: 361–374.PubMedCrossRefGoogle Scholar
  95. 95.
    Maltz DL, Nadas AS. Agenesis of the lung. Pediatrics 1968; 42: 175–188.PubMedGoogle Scholar
  96. 96.
    Boxer RA, Hayes CJ, Hordof AJ, Mellins RB. Agenesis of the left lung and total anomalous pulmonary venous connection. Chest 1978; 74: 106–109.PubMedCrossRefGoogle Scholar
  97. 97.
    Mygind H, Paulsen SM. Agenesis of the right lung. Arch Pathol Lab Med 1980; 104: 444.PubMedGoogle Scholar
  98. 98.
    Harrison MR, Hendren WH. Agenesis of the lung complicated by vascular compression and bronchomalacia. J Pediatr Surg 1975; 10: 813–817.PubMedCrossRefGoogle Scholar
  99. 99.
    Storey CF, Marrangoni AG. Lobar agenesis of the lung. J Thorac Surg 1954; 28: 536–543.PubMedGoogle Scholar
  100. 100.
    Sbokos CG, McMillan. Agenesis of the lung. Br J Dis Chest 1977; 71: 183–197.PubMedCrossRefGoogle Scholar
  101. 101.
    Ryland D, Reid L. Pulmonary aplasia-a quantitative analysis of the development of the single lung. Thorax 1971; 26: 602–609.PubMedCrossRefGoogle Scholar
  102. 102.
    Potter EL, Craig JM. Pathology of the fetus and infant. 3d ed. Chicago: Year Book Medical, 1975: 21.Google Scholar
  103. 103.
    Gruenwald P, Minh HN. Evaluation of body and organ weights in perinatal pathology. Am J Clin Pathol 1960; 34: 247–253.PubMedGoogle Scholar
  104. 104.
    Reale FR, Esterly JR. Pulmonary hypoplasia: a morpho-metric study of the lungs of infants with diaphragmatic hernia, anencephaly, and renal malformations. Pediatrics 1973; 51: 91–96.PubMedGoogle Scholar
  105. 105.
    Emery JL, Mithal A. The number of alveoli in the terminal respiratory unit of man during late intrauterine life and childhood. Arch Dis Child 1960; 35: 544–547.PubMedCrossRefGoogle Scholar
  106. 106.
    Askenazi SS, Perlman M. Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis. Arch Dis Child 1979; 54: 614–618.PubMedCrossRefGoogle Scholar
  107. 107.
    Scherle W. A simple method for volumetry of organs in quantitative sterology. Mikroskopie 1970; 26: 57–60.PubMedGoogle Scholar
  108. 108.
    Thurlbeck WM. Postmortem lung volumes. Thorax 1979; 34: 735–739.PubMedCrossRefGoogle Scholar
  109. 109.
    Wigglesworth JS, Desai R. Use of DNA estimation for growth assessment in normal and hypoplastic fetal lungs. Arch Dis Child 1981; 56: 601–605.PubMedCrossRefGoogle Scholar
  110. 110.
    Cooney TD, Thurlbeck WM. The radial alveolar count method of Emery and Mithal: a reappraisal. 2. Intrauterine and early postnatal lung growth. Thorax 1982; 37: 580–583.PubMedCrossRefGoogle Scholar
  111. 111.
    Cooney TD, Thurlbeck WM. The radial alveolar count of Emery and Mithal: a reappraisal. 1. Postnatal lung growth. Thorax 1982; 37: 572–579.PubMedCrossRefGoogle Scholar
  112. 112.
    Page DN, Stocker JT. Anomalies associated with pulmonary hypoplasia. Am Rev Respir Dis 1982; 125: 216–221.PubMedGoogle Scholar
  113. 113.
    Nakayama DK, Gluk PL, Harrison MR, Villa RL, Noall R. Experimental pulmonary hypoplasia due to oligohydramnios and its reversal by relieving thoracic compression. J Pediatr Surg 1983; 18: 347–353.PubMedCrossRefGoogle Scholar
  114. 114.
    Perlman M, Williams F, Hirsch W. Neonatal pulmonary hypoplasia after prolonged leakage of amniotic fluid. Arch Dis Child 1976; 51: 349–353.PubMedCrossRefGoogle Scholar
  115. 115.
    Thomas IT, Smith DW. Oligohydramnios, cause of the nonrenal features of Potter’s syndrome, including pulmonary hypoplasia. J Pediatr 1974; 84: 811–814.PubMedCrossRefGoogle Scholar
  116. 116.
    Goldstein JD, Reid LM. Pulmonary hypoplasia resulting from phrenic nerve agenesis and diaphragmatic amyoplasia. J Pediatr 1980; 97: 282–287.PubMedCrossRefGoogle Scholar
  117. 117.
    Swischuk LE, Richardson CJ, Nichols MM, Ingman MJ. Bilateral pulmonary hypoplasia in the neonate. AJR 1979; 133: 1057–1063.PubMedCrossRefGoogle Scholar
  118. 118.
    Swischuk LE, Richardson CJ, Nichols MM, Ingman MJ. Primary pulmonary hypoplasia in the neonate. j Pediatr 1979; 95: 573–577.Google Scholar
  119. 119.
    Hislop A, Hey E, Reid L. The lungs in congenital bilateral renal agenesis and dysplasia. Arch Dis Child 1979; 54: 32–38.PubMedCrossRefGoogle Scholar
  120. 120.
    Stocker JT. Congenital cytomegalovirus infection presenting as massive ascites with secondary pulmonary hypoplasia. Hum Pathol 1985; 16: 1 173–1175.CrossRefGoogle Scholar
  121. 121.
    Novak RM. Laryngotracheoesophageal cleft and unilateral pulmonary hypoplasia in twins. Pediatrics 1981; 67: 732–734.PubMedGoogle Scholar
  122. 122.
    Symonds DA, Driscoll SC. Massive fetal ascites, urethral atresia and cytomegalic inclusion disease. Am J Dis Child 1974; 127: 895–897.PubMedGoogle Scholar
  123. 123.
    Ellis MI, Hey EN, Walker W. Neonatal death in babies with rhesus isoimmunization. Q J Med 1979; 190: 211–225.Google Scholar
  124. 124.
    Wigglesworth JS, Winston RML, Barttett K. Influence of the CNS in fetal lung development. Arch Dis Child 1977; 52: 965–967.PubMedCrossRefGoogle Scholar
  125. 125.
    Pena SDJ, Shokeir MHK. Syndrome of camptodactly, multiple ankylosis, facial anomalies, and pulmonary hypoplasia: a lethal condition. J Pediatr 1974; 85: 373–375.PubMedCrossRefGoogle Scholar
  126. 126.
    Derksen OS. Scimitar syndrome and pulmonary sequestration. Radiol Clin North Am 1977; 46: 81–93.Google Scholar
  127. 127.
    Felson B. Pulmonary agenesis and related anomalies. Semin Roentgenol 1972; 7: 17–30.PubMedCrossRefGoogle Scholar
  128. 128.
    Farnsworth AE, Ankeney JL. The spectrum of the scimitar syndrome. J Thorac Cardiovasc Surg 1974; 68: 37–42.PubMedGoogle Scholar
  129. 129.
    Neil CA, Ferencz C, Sabiston DC, Sheldon H. The familial occurrence of hypoplastic right lung with systemic arterial supply and venous drainage: “scimitar syndrome.” Bull Johns Hopkins Hosp 1960; 107: 1–15.Google Scholar
  130. 130.
    Dresler S. Massive pleural effusion and hypoplasia of the lung accompanying extralobar pulmonary sequestration. Hum Pathol 1981; 12: 862–864.PubMedCrossRefGoogle Scholar
  131. 131.
    Lucaya J, Garcia-Conesa JA, Bernado L. Pulmonary sequestration associated with unilateral pulmonary hypoplasia and massive pleural effusion. Pediatr Radiol 1984; 14: 228–229.PubMedCrossRefGoogle Scholar
  132. 132.
    Turkel SB. Conditions associated with non-immune hydrops fetalis. Clin Perinatol 1982; 9: 613–625.PubMedGoogle Scholar
  133. 133.
    Stocker JT. Sequestration of the lung. Semin Diagn Pathol Path 1986; 3: 106–121.Google Scholar
  134. 134.
    Savic B, Birtel FJ, Tholen W, Funke HD, Knoche R. Lung sequestration: report of seven cases and review of 540 published cases. Thorax 1979; 34: 96–101.PubMedCrossRefGoogle Scholar
  135. 135.
    Kaude JV, Laurin S. Ultrasonographic demonstration of systemic artery feeding extrapulmonary sequestration. Pediatr Radiol 1984; 14: 226–227.PubMedCrossRefGoogle Scholar
  136. 136.
    Mahadevia PS. Necrotizing vasculitis in an extralobar sequestered lung. Arch Pathol Lab Med 1980; 104: 114.PubMedGoogle Scholar
  137. 137.
    Maul! KI, McElvein RB. Infarcted extralobar pulmonary sequestration. Chest 1975; 68: 98–99.PubMedCrossRefGoogle Scholar
  138. 138.
    Stocker JT, Madewell JE, Drake RM. Congenital cystic adenomatoid malformation of the lung: classification and morphologic spectrum. Hum Pathol 1977; 8: 155171.Google Scholar
  139. 139.
    Stocker JT, Drake RM, Madewell JE. Cystic and congenital lung diseases in the newborn. Perspect Pediatr Pathol 1978; 4: 93–154.PubMedGoogle Scholar
  140. 140.
    Adeyemo AO, Omole CO, Oyedeyi GA. Congenital lobar emphysema of left upper lobe: a case report. Scand J Thorac Cardiovasc Surg 1983; 17; 57–59.PubMedCrossRefGoogle Scholar
  141. 141.
    Wall MA, Eisenberg JD, Campbell JR. Congenital lobar emphysema in a mother and daughter. Pediatrics 1982; 70: 131–133.PubMedGoogle Scholar
  142. 142.
    Iancur T, Boyanova Y, Eilam N, Eilan E, Lerner MA. Infantile sub-lobar emphysema with tracheal bronchus. Acta Paediatr Scand 1975; 64: 551–554.CrossRefGoogle Scholar
  143. 143.
    Keller MS. Congenital lobar emphysema with tracheal bronchus. J Can Assoc Radiol 1983; 34: 306–307.PubMedGoogle Scholar
  144. 144.
    Capitano MA, Ramos R, Kirkpatrick JA. Pulmonary sling. AJR 1971; 112: 28–34.CrossRefGoogle Scholar
  145. 145.
    Sulayman R, Thilenius O, Replogle R, Arcilla RA. Unilateral emphysema in total anomalous pulmonary venous return. J Pediatr 1975; 87: 433–435.PubMedCrossRefGoogle Scholar
  146. 146.
    Miller KE, Edwards DK, Hilton S, Collins D, Lynch F, Williams R. Acquired lobar emphysema in premature infants with bronchopulmonary dysplasia: an iatrogenic disease? Radiology 1981; 138: 589–592.PubMedGoogle Scholar
  147. 147.
    Hislop A, Reid L. New pathological findings in emphysema of childhood: 2. Overinflation of a normal lobe. Thorax 1971; 26: 190–194.PubMedCrossRefGoogle Scholar
  148. 148.
    Schneider JR, St Cyr JA, Thompson TR, Johnson DE, Burke BA, Foker JE. The changing spectrum of cystic pulmonary lesions requiring surgical resection in infants. J Thorac Cardiovasc Surg 1985; 89: 332–339.PubMedGoogle Scholar
  149. 149.
    Man DWK, Handy MH, Hendry GMA, Bisset WH, Forfar JO. Congenital lobar emphysema: Problems in diagnosis and management. Arch Dis Child 1983; 58: 709712.Google Scholar
  150. 150.
    Morgan WJ, Lemen RJ, Rojas R. Acute worsening of congenital lobar emphysema with subsequent spontaneous improvement. Pediatrics 1983; 71: 844–848.PubMedGoogle Scholar
  151. 151.
    Robotham JL, Menkes HA, Chipps BE, et al. A physiologic assessment of segmental bronchial atresia. Am Rev Respir Dis 1980; 121: 533–540.PubMedGoogle Scholar
  152. 152.
    McBride JT, Wohl MEB, Strieder DJ, et al. Lung growth and airway function after lcbectomy in infancy for congenital lobar emphysema. J Clin Invest 1980; 66: 96 2970.Google Scholar
  153. 153.
    Frenckrier B, Freyschuss U. Pulmonary function after lobectomy for congenital lobar emphysema and congenital cystic adenomatoid malformation: a follow-up study. Scand J Thorac Cardiovasc Surg 1982; 16: 293298.Google Scholar
  154. 154.
    Williams AJ, Schuster SR. Bronchial atresia associated with a bronchogenic cyst. Chest 1985; 87: 396–398.PubMedCrossRefGoogle Scholar
  155. 155.
    Jones JC, Almond CH, Snyder HM, Meyer BW, Patrick JR. Lobar emphysema and congenital heart disease in infancy. J Thorac Cardiovasc Surg 1965; 49: 1–10.PubMedGoogle Scholar
  156. 156.
    Pierce WS, DeParedes CG, Friedman S, Waldhausen JA. Concomitant congenital heart disease and lobar emphysema in infants. Ann Surg 1970; 172: 951–956.PubMedCrossRefGoogle Scholar
  157. 157.
    Roguin N, Peleg H, Lemer J, Naveh Y, Reis E. The value of cardiac catheterization and cineangiography in infantile lobar emphysema. Pediatr Radiol 1980; 10: 71–74.PubMedCrossRefGoogle Scholar
  158. 158.
    Bolande RP, Schneider AF, Boggs JD. Infantile lobar emphysema: etiologic concept. Arch Pathol Lab Pathol 1956; 61: 289–294.Google Scholar
  159. 159.
    Campbell PE. Congenital lobar emphysema: etiological studies. Aust Paediatr J I969; 5: 226–233.Google Scholar
  160. 160.
    Warner JO, Rubin S, Heard BE. Congenital lobar emphysema: a case with bronchial atresia and abnormal bronchial cartilage. Br J Dis Chest 1982; 76; 177184.Google Scholar
  161. 161.
    Hislop A, Reid L. New pathological findings in emphysema of childhood: 1. Polyalveolar lobe with emphysema. Thorax 1970; 25: 682–690.PubMedCrossRefGoogle Scholar
  162. 162.
    Munnell ER, Lambird PA, Austin RL. Polyalveolar lobe causing lobar emphysema of infancy. Ann Thorac Surg 1973; 16: 624–628.PubMedCrossRefGoogle Scholar
  163. 163.
    Topper D, Schuster S, McBride J, et al. Polyalveolar lobe: anatomic and physiologic parameters and their relationship to congenital lobar emphysema. J Pediatr Surg 1980; 15: 931–937.CrossRefGoogle Scholar
  164. 164.
    Felman AH, Rhatigan RM, Pierson KK. Pulmonary lymphangiectasis; observation in 17 patients and proposed classification. AJR 1972; 116: 548–558.CrossRefGoogle Scholar
  165. 165.
    Noonan JA, Walters LR, Reeves JT. Congenital pulmonary lymphangiectasis. Am J Dis Child 1970; 120: 314319.Google Scholar
  166. 166.
    Hunter WS, Becroft DMO. Congenital pulmonary lymphangiectasis associated with pleural effusions. Arch Dis Child 1984; 59: 278–279.PubMedCrossRefGoogle Scholar
  167. 167.
    Gardner TW, Domm AC, Brock CE, Pruitt AW. Congenital pulmonary lymphangiectasis. Clin Pediatr (Phila) 1983; 22: 75–78.CrossRefGoogle Scholar
  168. 168.
    Wilson RH, Duncan A, Hume R, Bain AD. Prenatal pleural effusion associated with congenital pulmonary lymphangiectasis. Prenat Diagn 1985; 5: 73–76.PubMedCrossRefGoogle Scholar
  169. 169.
    Siegal A, Katsenstein M, Wolach B. Neonatal pneumothorax, a rare complication of pulmonary cystic lymphangiectasis. Eur J Respir Dis 1985; 66: 153–157.PubMedGoogle Scholar
  170. 170.
    Scott-Emuakpor AB, Warren ST, Kapur S, Quiachon EB, Higgins JV. Familial occurrence of congenital pulmonary lymphangiectasis: genetic implications. Am J Dis Child 1981; 135: 532–534.PubMedGoogle Scholar
  171. 171.
    Pemot C, Bernard C, Hoeffel JG. Congenital pulmonary lymphangiectasis of late onset associated with congenital heart disease. Arch Fr Pediatr 1984; 41: 617–622.Google Scholar
  172. 172.
    Esterly JR, Oppenheimer EH. Lymphangiectasis and other pulmonary lesions in the asplenia syndrome. Arch Pathol Lab Med 1970; 90: 553–560.Google Scholar
  173. 173.
    France NE, Brown RJK. Congenital pulmonary lymphangiectasis; report of 11 examples with special reference to cardiovascular findings. Arch Dis Child 1971; 46: 528–532.PubMedCrossRefGoogle Scholar
  174. 174.
    Rhatigan RM, Hobin FP. Congenital pulmonary lymphangiectasis and ichthyosis congenita. Am J Clin Pathol 1970; 53: 95–99.PubMedGoogle Scholar
  175. 175.
    Chin KY, Tang MY. Congenital adenomatoid malformation of one lobe of a lung with general anasarca. Arch Pathol Lab Med 1949; 48: 221–229.Google Scholar
  176. 176.
    VanDijk C, Wagenvoort CA. The various type of congenital adenomatoid malformation of the lung. J Pathol 1973; 110: 131–134.CrossRefGoogle Scholar
  177. 177.
    Madewell JE, StockerJT, KorsowerJM. Cystic adenomatoid malformation of the lung. AJR 1975; 124: 436–448.CrossRefGoogle Scholar
  178. 178.
    Kwitten J, Reiner L. Congenital cystic adenomatoid malformation of the lung. Pediatrics 1962; 30: 759–768.Google Scholar
  179. 179.
    Avitabile AM, Hulnick DH, Greco A, Feiner HD. Congenital cystic adenomatoid malformation of the lung in adults. Am J Surg Pathol 1984; 8: 193–202.PubMedCrossRefGoogle Scholar
  180. 180.
    Miller RK, Sieber WK, Yunis EJ. Congenital adenomatoid malformation of the lung: a report of 17 cases and review of the literature. Pathol Annu 1980; 15 (part 1): 387–402.PubMedGoogle Scholar
  181. 181.
    Wexler HA, Valdes Dapena M. Congenital cystic adenomatoid malformation: a report of 3 unusual cases. Radiology 1978; 126: 737–741.PubMedGoogle Scholar
  182. 182.
    Alt B, Shikes RH, Stanford RE, Silverberg SG. Ultra-structure of congenital cystic adenomatoid malformation of the lung. Ultrastruct Pathol 1982; 3: 217–228.PubMedCrossRefGoogle Scholar
  183. 183.
    Olson JL, Mendelsohn G. Congenital cystic adenomatoid malformation of the lung. Arch Pathol Lab Med 1978; 102: 248–251.PubMedGoogle Scholar
  184. 184.
    Glaves J, Baker JL. Spontaneous resolution of maternal hydramnios in congenital cystic adenomatoid malformation of the lung. Antenatal ultrasound features. Case report. Br J Obstet Gynaecol 1983; 90: 1065–1068.PubMedCrossRefGoogle Scholar
  185. 185.
    Diwan RV, Brennan JN, Philipson EH, Jain S, Bellon EM. Ultrasonic prenatal diagnosis of Type III congenital cystic adenomatoid malformation of lung. JCU 1983; 11: 218–221.PubMedGoogle Scholar
  186. 186.
    Cohen RA, Moskowitz PS, McCallum WD. Sonographic diagnosis of cystic adenomatoid malformation in-utero. Prenat Diagn 1983; 3: 139–143.PubMedCrossRefGoogle Scholar
  187. 187.
    Yadar K, Kataria S, Pathak IC. Congenital cystic lesion of the lung in a new-born. Int Surg 1982; 67: 430.Google Scholar
  188. 188.
    Benjavongkulchai S, Shuangshoti S. Congenital cystic adenomatoid malformation of the lung. J Med Assoc Thai 1982; 65: 333–339.PubMedGoogle Scholar
  189. 189.
    Bruno E. Congenital cystic adenomatoid malformation. IMJ 1982; 162: 485, 506–508.Google Scholar
  190. 190.
    Cachia R, Sobonya RE. Congenital cystic adenomatoid malformation of the lung with bronchial atresia. Hum Pathol 1981; 12: 947–950.PubMedCrossRefGoogle Scholar
  191. 191.
    Donn SM, Martin JN, White SJ. Antenatal ultrasound findings in cystic adenomatoid malformation. Pediatr Radiol 1981; 10: 180–182.PubMedCrossRefGoogle Scholar
  192. 192.
    Nishibayashi SW, Andrassy RJ, Woolley MM. Congenital cystic adenomatoid malformation: a 30-year experiment. J Pediatr Surg 1981; 16: 704–706.PubMedCrossRefGoogle Scholar
  193. 193.
    Blane CE, Donn SM, Mori KW. Case report: congenital cystic adenomatoid malformation of the lung. J Comput Assist Tomogr 1981; 5: 418–420.PubMedCrossRefGoogle Scholar
  194. 194.
    Krous HF, Harper PE, Perlman M. Congenital cystic adenomatoid malformation in bilateral renal agenesis. Its mitigation of Potter’s syndrome. Arch Pathol Lab Med 1980; 104: 368–370.PubMedGoogle Scholar
  195. 195.
    Stevensen DK, Silverman FN, Churg AM, Shochat SJ. Unusual roentgenographic presentation of a congenital cystic malformation of the lung. Eur J Pediatr 1979; 132: 119–124.CrossRefGoogle Scholar
  196. 196.
    Bale, PM. Congenital cystic malformation of the lung. Am J Clin Pathol 1979; 71: 411–420.PubMedGoogle Scholar
  197. 197.
    Weinberg AG, Zumwalt RE. Bilateral nephromegaly and multiple pulmonary cysts. Am J Clin Pathol 1977; 67: 284–288.PubMedGoogle Scholar
  198. 198.
    Chi JG, Shong YK. Diffuse straited muscle heteroplasia of the lung. Arch Pathol Lab Med 1982; 106: 641–644.PubMedGoogle Scholar
  199. 199.
    Vilanova JR, Burgos-Bretones J, Aguirre JM, RiveraPomar JM. Rhabdomyomatous dysplasia of lung and congenital diaphragmatic hernia. J Pediatr Surg 1983; 18: 201–203.PubMedCrossRefGoogle Scholar
  200. 200.
    Ueda K, Gruppo R, Unger F, Martin L, Bove K. Rhabdomyosarcoma of lung arising in congenital cystic adenomatoid malformation. Cancer 1977; 40: 383–388.PubMedCrossRefGoogle Scholar
  201. 201.
    Krous HF, Sexauer CL. Embryonal rhabdomyosarcoma arising within a congenital bronchogenic cyst in a child. J Pediatr Surg 1981; 16: 506–508.PubMedCrossRefGoogle Scholar
  202. 202.
    Haller JO, Kauffman SL, Kassner EG. Congenital mesenchymal tumour of the lung. Br J Radiol 1977; 50: 217219.Google Scholar
  203. 203.
    Fisher JE, Nelson SJ, Allen JE, Holzman RS. Congenital cystic adenomatoid malformation of the lung: a unique variant. Am J Dis Child 1982; 136: 1071–1074.PubMedGoogle Scholar
  204. 204.
    Janney CG, Askin FB, Kuhn C. Congenital alveolar capillary dysplasia; an unusual cause of respiratory distress in the newborn. Am J Clin Pathol 1981; 76: 72 2727.Google Scholar
  205. 205.
    MacMahon HE. Congenital alveolar dysplasia of the lung. Am J Pathol 1984; 24: 919–930.Google Scholar
  206. 206.
    Kaufman N, Spiro RK. Congenital alveolar dysplasia of the lung. Arch Pathol Lab Med 1951;49:431 ‘140.Google Scholar
  207. 207.
    Daentl DL, Passarge E. Familial agenesis of the diaphragm. Birth Defects 1972; 8: 24–26.Google Scholar
  208. 208.
    Benjamin HB. Agenesis of the left hemidiaphragm. J Thorac Cardiovasc Surg 1963; 46: 265–270.PubMedGoogle Scholar
  209. 209.
    Eichelberger MR, Kettrich RG, Hoelzer DJ, Swellow DB, Schnaufer L. Agenesis of the left diaphragm: surgical repair and physiologic consequences. J Pediatr Surg 1980; 15: 395–397.PubMedCrossRefGoogle Scholar
  210. 210.
    Neville WE, Clowes GA. Congenital absence of hemidiaphragm and use of a lobe of liver in its surgical repair. Arch Surg 1954; 69: 282–290.CrossRefGoogle Scholar
  211. 211.
    Ikeda T, Ishihara H, Yoshimatru H, et al. Accessory diaphragm associated with congenital posterolateral diaphragmatic hernia, aberrant systemic artery to the right lower lobe and anomalous pulmonary vein. J Thorac Cardiovasc Surg 1972; 64: 18–25.PubMedGoogle Scholar
  212. 212.
    Kenauoglu A, Tunchilek E. Accessory diaphragm on the left side. Pediatr Radiol 1978; 7: 172–174.CrossRefGoogle Scholar
  213. 213.
    Hart JC, Cohen IT, Ballantine TVN, Varrano LF. Accessory diaphragm in an infant. J Pediatr Surg 1981; 16: 947–948.PubMedCrossRefGoogle Scholar
  214. 214.
    Nazarian M, Currarino G, Webb WR, Willis K, Kiphart RJ, Wilson HE. Accessory diaphragm: report of a case with complete physiological evaluation and surgical correction. J Thorac Cardiovasc Surg 1971; 61: 293–299.PubMedGoogle Scholar
  215. 215.
    Hansen J, James S, Burrington J, Whitfield J. The decreasing incidence of pneumothorax and improving survival of infants with diaphragmatic hernia. J Pediatr Surg 1984; 19: 385–388.PubMedCrossRefGoogle Scholar
  216. 216.
    Starrett RW, deLorimier AA. Congenital diaphragmatic hernia in lambs: hemodynamic and ventilatory changes with breathing. J Pediatr Surg 1975; 10: 575–582.PubMedCrossRefGoogle Scholar
  217. 217.
    Levin DL. Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic hernia. J Pediatr 1978; 92: 805–809.PubMedCrossRefGoogle Scholar
  218. 218.
    Dibbins AW, Wiener ES. Mortality from neonatal diaphragmatic hernia. J Pediatr Surg 1974; 9: 653–662.PubMedCrossRefGoogle Scholar
  219. 219.
    Mishalany HG, Nakada K, Woolley MM. Congenital diaphragmatic hernias. Arch Surg 1979; 1 14: 1118–1123.CrossRefGoogle Scholar
  220. 220.
    Bloss RS, Aranda JV, Beardmore HE. Congenital diaphragmatic hernia: pathophysiology and pharmacologic support. Surgery 1981; 89: 518–524.PubMedGoogle Scholar
  221. 221.
    Campbell DN, Lilly JR. The clinical spectrum of right Bochdulek’s hernia. Arch Surg 1982; 117: 341–344.PubMedCrossRefGoogle Scholar
  222. 222.
    Banagale RC, Watters JÍ-I. Delayed right-sided diaphragmatic hernia following group B streptococcal infection. Hum Pathol 1983; 14: 67–69.PubMedCrossRefGoogle Scholar
  223. 223.
    Greenwood RD, Rosenthal A, Nadas AS. Cardiovascular abnormalities associated with congenital diaphragmatic hernia. Pediatrics 1976; 57: 92–97.PubMedGoogle Scholar
  224. 224.
    Jewett TC, Thomson NB. Iatrogenic eventration of the diaphragm in infancy. J Thorac Cardiovasc Surg 1964; 48: 861–866.PubMedGoogle Scholar
  225. 225.
    Paris F, Blasco E, Canto A, Tarazona V, Casillas M. Diaphragmatic eventration in infants. Thorax 1973; 28: 66–72.PubMedCrossRefGoogle Scholar
  226. 226.
    Wayne ER, Campbell JB, Burrington JD, Davis WS. Eventration of the diaphragm. J Pediatr Surg 1974; 9: 643–651.PubMedCrossRefGoogle Scholar
  227. 227.
    Thomas TV. Congenital eventration of the diaphragm. Ann Thorac Surg 1970; 10: 180–192.PubMedCrossRefGoogle Scholar
  228. 228.
    O’Shea PA. Chronic granulomatous disease of childhood. Perspect Pediatr Pathol 1981; 6: 237–258.Google Scholar
  229. 229.
    Schafer IA. Vascular and other genetic diseases affecting the lungs. In: Baum GL, Wolinsky E, eds. Textbook of pulmonary diseases. 3d ed. Boston: Little, Brown, 1983: 1261–1276.Google Scholar

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© Springer Science+Business Media New York 1988

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  • J. Thomas Stocker

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