Abstract
Asbestos, a fibrous mineral rock of the earth’s crust, is well known as a potential causative agent of pulmonary disease. Throughout the past 25 years there has been increasing interest in the pathogenesis of asbestos lung disease, with emphasis on mineralogy and epidemiology as well as its pathology. Such studies have been timely because we are now experiencing an explosion of asbestos-associated lung diseases, resulting in large part from occupational exposures during World War II. This lengthy clinical latency period of 20–40 years is primarily responsible for the initial failure of industry to appreciate the potentially devastating effects of this respirable fiber.
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References
Wolfe JA. Asbestos mineral resources: a world review. New York: Chapman and Hall, 1984: 197 – 200.
Clifton RA. Asbestos. In: McGraw-Hill encyclopedia of science and technology. Vol. 1. 5th ed. New York: McGraw-Hill, 1982: 744 – 745.
Selikoff IJ, Lee DH. Asbestos and disease. New York: Academic Press, 1978.
Report of American Medical Association Council on Scientific Affairs. A physicians’ guide to asbestos related diseases. JAMA 1984; 252: 2593 – 2597.
Garfinkel L. Asbestos: historical perspective. CA 1984; 34: 44 – 67.
Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Provence. Br J Ind Med 1960; 17: 260 – 271.
Selikoff IJ, Churg J, Hammond EC. Asbestos exposure and neoplasia. JAMA 1964; 188: 22 – 26.
Pancoast HK, Miller TG, Landis HRM. A roentgenologic study of the effects of dust inhalation upon the lungs. AJR 1918; 5: 129 – 138.
Cooke WE. Fibrosis of the lungs due to inhalation of asbestos dust. Br Med J [Clin Res] 1924; 1: 147.
Cooke WE. Pulmonary asbestosis. Br Med J [Clin Res] 1927; 2: 1024 – 1025.
Cooke WE. Asbestos dust and the curious bodies found in pulmonary asbestosis. Br Med J [Clin Res] 1929; 2: 578 – 580.
Simson FW. Pulmonary asbestosis in South Africa. Br Med J [Clin Res] 1928; 1: 885 – 887.
Merewether ERA, Price CV. Report on effects of asbes tos dust on the lungs and dust suppression in the asbestos industry. London: H M Stationery Office, 1930.
Lynch KM, Smith WA. Asbestos bodies in sputum and lung. JAMA 1930; 95: 659 – 661.
Mills RG. Pulmonary asbestosis. Report of a case. Minn Med 1930; 13: 495 – 499.
Lynch KM, Smith WA. Pulmonary asbestosis. III. Carcinoma of lung in asbesto-silicosis. Am J Cancer 1935; 24: 56 – 64.
Homburger F. The coincidence of primary carcinoma of the lungs and pulmonary asbestosis. Analysis of literature and report of three cases. Am J Pathol 1943; 19: 797 – 807.
Doll R. Mortality from lung cancer in asbestos workers. Br J Ind Med 1955; 12: 81 – 86.
Klemperer P, Rabin CB. Primary neoplasms of the pleura: a report of five cases. Arch Pathol Lab Med 1931; 11: 385 – 412.
Mallory TB, Castleman B, Parris EE. Mesothelioma of pleura and pericardium. N Engl J Med 1947; 236: 407 – 412.
Craighead JE. Asbestos: an environmental reality. JAMA 1984; 252: 3292 – 3293.
Dodson RF, Greenberg SD, Williams MG, Corn CJ, O’Sullivan MF, Hurst GA. Asbestos content in lungs of occupationally and nonoccupationally exposed individuals. JAMA 1984; 252: 68 – 71.
Selikoff IJ, Hammond EC, Seidman H. Mortality experience of insulation workers in the United States and Canada, 1943–1976. Ann NY Acad Sci 1979; 330: 91 – 116.
Selikoff IJ, Hammond EC. Asbestos and smoking. JAMA 1979; 242: 458.
Berry G, Newhouse ML, Turok M. Combined effect of asbestos exposure and smoking on mortality from lung cancer in factory workers. Lancet 1972; 2: 476 – 478.
Enterline P, DeCoufle P, Henderson V. Mortality in relation to occupational exposure in the asbestos industry. J Occup Med 1972; 14: 897 – 903.
Enterline PE, Henderson V. Type of asbestos and respiratory cancer in the asbestos industry. Arch Environ Health 1973; 27: 312 – 317.
McDonald JC, Becklake MR, Gibbs GW, McDonald A, Rossiter CE. The health of chrysotile asbestos mine and mill workers of Quebec. Arch Environ Health 1974; 28: 61 – 68.
Berry G, Newhouse ML. Mortality of workers manufacturing friction materials using asbestos. Br J Ind Med 1983; 40: 1 – 7.
Wagner JC, Gilson JC, Berry G, Timbrell V. Epidemiology of asbestos cancers. Br Med Bull 1971; 27: 71 – 96.
Harington JS. Fiber carcinogenesis: Epidemiologic observations and the Stanton hypothesis. JNCI 1981; 67: 977 – 989.
Stanton MF, Wrench C. Mechanisms of mesothelioma induction with asbestos and fibrous glass. JNCI 1972; 48: 797 – 821.
Stanton MF, Layord M, Tegeris A, et al. Relation of particle dimension to carcinogenicity in amphibole asbestos and other fibrous minerals. JNCI 1981; 67: 965 – 975.
Gross P. Is short fibered asbestos dust a biological hazard? Arch Environ Health 1974; 29: 115 – 117.
Becklake MR. Asbestos-related diseases of the lung and other organs: their epidemiology and implications for clinical practice. Am Rev Respir Dis 1976; 114: 187 – 227.
Artvinli M, Baris YI. Malignant mesotheliomas in a small village in the Anatolian region of Turkey: an epidemiologic study. JNCI 1979; 63: 17 – 22.
Newhouse ML, Thompson H. Mesothelioma of the pleura and peritoneum following exposure to asbestos in the London area. Br j Ind Med 1965; 22: 261 – 269.
Anderson HA, Lilis R, Daum SM, Fischbein AS, Selikoff IJ. Household contact asbestos neoplastic risk. Ann NY Acad Sci 1976; 271: 311 – 323.
Craighead JE, Mossman BT. The pathogenesis of asbestos associated disease. N Engl J Med 1982; 306: 1446 – 1455.
Churg A. Current issues in the pathologic and minera-logic diagnosis of asbetos-induced disease. Chest 1983; 84: 275 – 280.
Walker AM, Loughlin JE, Friedlander ER, Rothman KJ, Dreyer NA. Projections of asbestos related disease, 1980–2009. J Occup Med 1983; 25: 409 – 425.
Weill H. Asbestos-associated diseases: science, public policy and litigation. Chest 1984; 84: 601 – 608.
Kuhn C. The cells of the lung and their organelles. In: Crystal RG, ed. The biochemical basis of pulmonary function. New York: Marcel Dekker, 1976: 3 – 37.
Wilkey DD, Lee PS, Hass FJ, Gerrity TR, Yeates DB, Laurence RV. Mucociliary clearance of deposited particles from the human lung. Arch Environ Health 1980; 35: 294 – 303.
Bowden DH, Adamson IY. Role of monocytes and interstitial cells in the generation of alveolar macrophages. Lab Invest 1980; 42: 511 – 517.
Craighead JE, Abraham JL, Churg A, et al. The pathology of asbestos associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading scheme. Arch Pathol Lab Med 1982; 106: 542 – 596.
Timbrell V. The inhalation of fibrous dusts. Ann NY Acad Sci 1965; 132: 255 – 273.
Harington JS, Allison AC, Badami DV. Mineral fibers: chemical, physiochemical and biological properties. Adv Pharmacol Chemother 1975; 12: 291 – 401.
Warheit DB, George G, Hill LH, Snyderman R, Brody AR. Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. Lab Invest 1985; 52: 505 – 514.
Pinkerton KE, Pratt PC, Brody AR, Crapo JD. Fiber localization and its relationship to lung reaction in rats after chronic inhalation of chrysotile asbestos. Am J Pathol 1984; 117: 484 – 498.
Davis JMG. The ultrastructure of asbestos bodies from guinea pigs lung. Br J Exp Pathol 1964; 45: 634 – 641.
Suzuki Y, Churg J. Structure and development of the asbestos body. Am J Pathol 1969; 55: 79 – 91.
Pooley FD. Asbestos bodies: their formation, composition and character. Environ Res 1972; 5: 363 – 379.
Morgan A, Holmes A. Concentrations and dimensions of coated and uncoated asbestos fibers in the human lung. Br J Ind Med 1980; 37: 25 – 32.
Dodson RF, O’Sullivan MF, Corn CJ, Williams MG, Hurst GA. Ferruginous body formation on a nonasbestos material. Arch Pathol Lab Med 1985; 109: 849 – 852.
Greenberg SD. Asbestos lung disease. Semin Respir Med 1982; 4: 130 – 137.
Farley MT, Greenberg SD, Shuford EH, Hurst GA, Spivey CG, Christianson CS. Ferruginous bodies in sputa of former asbestos workers. Acta Cytol (Baltimore) 1977; 21: 693 – 700.
Roggli VL, Greenberg SD, Seitzman LH, et al. Pulmonary fibrosis, carcinoma and ferruginous body counts in amosite asbestos workers. Am J Clin Pathol 1980; 73: 496 – 503.
Dodson RF, Williams MG, O’Sullivan MF, Corn CJ, Greenberg SD, Hurst GA. Ferruginous bodies and uncoated fiber contents in the lungs of former asbestos workers. Am Rev Respir Dis 1985; 132: 143 – 147.
Gross P, Cralley LJ, de Treville RTP. “Asbestos” bodies: their nonspecificity. Am Ind Hyg Assoc J 1967; 28: 541 – 552.
Gross P, de Treville RTP, Cralley LJ, Davis JMG. Pulmonary ferruginous bodies: development in response to filamentous dusts and a method for isolation and concentration. Arch Pathol Lab Med 1968; 85: 539 – 546.
Davis JMG, Gross P, de Treville RTP. Ferruginous bodies in guinea pigs. Arch Pathol Lab Med 1970; 89: 364 – 373.
Crouch E, Churg A. Ferruginous bodies and the histologic evaluation of dust exposure. Am J Surg Pathol 1984; 8: 109 – 116.
Smith MJ, Naylor B. A method for extracting ferruginous bodies from sputum and pulmonary tissue. Am J Clin Pathol 1972; 58: 250 – 254.
Churg A. Fiber counting and analysis in the diagnosis of asbestos related disease. Hum Pathol 1982; 13: 381 – 392.
Churg A, Warnock ML, Green N. Analysis of the cores of ferruginous (asbestos) bodies from the general population: true asbestos bodies and pseudoasbestos bodies. Lab Invest 1970; 40: 31 – 38.
Churg A, Warnock ML. Analysis of the cores of ferruginous (asbestos) bodies from the general population: Patients with environmental exposure. Lab Invest 1979; 40: 622 – 626.
Roggli VL, McGavran MH, Subach J, Sybers HD, Greenberg SD. Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma. Cancer 1982; 50: 2423 – 2432.
Roggli VL, Pratt PC. Numbers of asbestos bodies in iron-stained tissue sections in relation to asbestos body counts in lung tissue digests. Hum Pathol 1983; 14: 355 – 361.
Meurmann L. Asbestos bodies and pleural plaques in
a Finnish series of autopsy cases. Acta Pathol Microbiol Immunol Scand [Suppl] 1966; 8 (181): 1 – 107.
Roggli VL, Greenberg SD, McLarty JL, et al. Comparison of sputum and lung asbestos body counts in former asbestos workers. Am Rev Respir Dis 1980; 122: 941 – 945.
Sebastian P, Bignon J, Barris YI, Awad L, Petit G. Ferruginous bodies in sputum: an indication of exposure to airborne mineral fibers in the mesothelioma villages of Cappadocia. Arch Environ Health 1984; 39: 18 – 23.
McLarty JW, Farley MT, Greenberg SD, Hurst GA, Mabry LC. Statistical comparison of aerosol induced and spontaneous sputum specimens in the Tyler Asbestos Workers Program. Acta Cytol 1980; 24: 460 – 465.
DeVuyst PD, Jebwab J, Schandevyl W, et al. Bronchoalveolar lavage as an aid in the diagnosis of asbestos related diseases. Eur J Respir Dis [Suppl] 1981; 62 (113): 54 – 55.
DeVuyst P, Jebwab J, Dumortier P, Vandermoten G, Vande Weyer R, Yernault JC. Asbestos bodies in bronchoalveolar lavage. Am Rev Respir Dis 1982; 126: 972 – 976.
Rebuck AS, Braude AC. Bronchoalveolar lavage in asbestosis. Arch Intern Med 1983; 143: 950 – 952.
Wheeler TM, Greenberg SD, Lawrence CE, Jenkins DE, Coughlin DA. Comparison of sputum and bronchial washings for the detection of asbestos bodies. Acta Cytol (Baltimore) 1984; 28: 660.
Greenberg SD. Cytopathology of asbestos associated pulmonary disease. Diagn Cytopathol 1985; 1: 177 – 182.
Rosen P, Gordon P, Savino A, Melamed M. Ferruginous bodies in benign fibrous pleural plaques. Am J Clin Pathol 1973; 60: 608 – 612.
Whitwell F, Scott J, Grimshaw M. Relationship between occupations and asbestos fiber count of the lungs in patients with pleural mesothelioma, lung cancer and other diseases. Thorax 1977; 32: 377 – 386.
Wain SL, Roggli VL, Foster WL. Parietal pleural plaques, asbestos bodies and neoplasia: a clinical, pathologic and roentgenographic correlation of 25 consecutive cases. Chest 1984; 86: 707 – 713.
Jaurand MC, Bignon J, Sebastien P, Goni J. Leaching of chrysotile asbestos in human lungs. Environ Res 1977; 14: 245 – 254.
McFadden D, Wright J, Wiggs B, Churg A. Cigarette smoke increases the penetration of asbestos fibers into airway walls. Am J Pathol 1986; 123: 95 – 99.
McFadden D, Wright JL, Wiggs B, Churg A. Smoking inhibits asbestos clearance. Am Rev Respir Dis 1986; 133: 372 – 374.
Weiss W. Cigarette smoke, asbestos, and small irregular opacities. Am Rev Respir Dis 1984; 130: 293 – 301.
Filipenko D, Wright JL, Churg A. Pathologic change in the small airways of the guinea pig after amosite
asbestos exposure. Am J Pathol 1985; 119: 273 – 278.
Wright JL, Churg A. Morphology of small airway lesions in patients with asbestos exposure. Hum Pathol 1984; 15: 68 – 74.
Roggli VL, Johnston WW, Kaminsky DB. Asbestos bodies in fine needle aspirates of the lung. Acta Cytol (Baltimore) 1984; 28: 403 – 408.
Merchant JA, Klouda PT, Soutar CA, Parkes WR, Lawler SD, Turner-Warnock M. The HL-A system in asbestos workers. Br Med J 1975; 1: 189 – 191.
Morris DL, Greenberg SD, Lawrence EC. Immune response in asbestos exposed individuals. Chest 1985; 87: 278 – 280.
McGavin CR, Sheers G. Diffuse pleural thickening in asbestos workers: disability and lung function abnormalities. Thorax 1984; 39: 604 – 607.
Weil H, Hughes J, Waggenspack C. Influence of dose and fiber type on respiratory malignancy risk in asbestos cement manufacturing. Am Rev Respir Dis 1979; 120: 345 – 354.
Whitwell F, Newhouse ML, Bennett DR. A study of the histological cell types of lung cancer in workers suffering from asbestosis in the United Kingdom. Br J Ind Med 1974; 31: 298 – 303.
Stout AP, Murray MR. Localized pleural mesothelioma: Investigation of its characteristics and histogenesis by the method of tissue culture. Arch Pathol Lab Med 1942; 34: 951 – 964.
Stout AP. Mesotheliomas of the pleura and peritoneum. J Tenn Med Assoc 1951; 44: 409 – 411.
Foster EA, Ackerman LV. Localized mesotheliomas of the pleura: the pathologic evaluation of 18 cases. Am J Clin Pathol 1960; 34: 349 – 364.
Godwin MC. Diffuse mesotheliomas, with comment on their relationship to localized fibrous mesotheliomas. Cancer 1967; 10: 298 – 319.
McDonald A, McDonald JC. Malignant mesothelioma in North America. Cancer 1980; 46: 1650 – 1656.
Churg A. Malignant mesothelioma in British Columbia in 1982. Cancer 1985; 55: 672 – 674.
Hurst GA, Spivey CG, Matlage WT, et al. The Tyler Asbestos Workers Program. Arch Environ Health 1979; 34: 432 – 438.
McLarty JW, Greenberg SD, Hurst GA, et al. The clinical significance of ferruginous bodies in sputa. J Occup Med 1980; 22: 92 – 96.
Modin BE, Greenberg SD, Buffler PA, Lockhardt JA, Seitzman LH, Awe RA. The significance of asbestos bodies in a general hospital/clinic population. Acta Cytol (Baltimore) 1982; 26: 667 – 670.
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Greenberg, S.D. (1988). Asbestos. In: Dail, D.H., Hammar, S.P. (eds) Pulmonary Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3932-9_22
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DOI: https://doi.org/10.1007/978-1-4757-3932-9_22
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