Eosinophilic Infiltrates

  • David H. Dail


Eosinophilic infiltrates in the lung to be discussed in this chapter include asthma, eosinophilic pneumonia, allergic bronchopulmonary aspergillosis, mucoid impaction, and bronchocentric granulomatosis. These are often manifestations of immunologically mediated reactions confined to the lungs. The entities may frequently overlap with each other because of their often shared common eosinophilic cell response and symptoms of asthma, and, in some cases, common etiologies.


Allergy Clin Immunol Bronchial Wall Status Asthmaticus Sputum Eosinophilia Eosinophilic Pneumonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Beeson PB, Bass DA. The eosinophil. Vol. 14. Major problems in internal medicine series. Philadelphia: WB Saunders, 1977.Google Scholar
  2. 2.
    Cohen SG, Ottesen EA. The eosinophil, eosinophilia, 22. and eosinophil-related disorders. In: Middleton E Jr, Reed CE, Elles EF, eds. Allergy, principles and practice. 23. 2d ed. St Louis: Mosby, 1983: 701–769.Google Scholar
  3. 3.
    Weller PF. Eosinophilia. J Allergy Clin Immunol 1984; 73: 1–10. 24.Google Scholar
  4. 4.
    Crofton JW, Livingstone JL, Oswald NC, Roberts ATM. Pulmonary eosinophilia. Thorax 1952; 7: 1–35.PubMedCrossRefGoogle Scholar
  5. 5.
    Ottesen EA. Eosinophilia and the lung. In: Kirkpatrick 25. CH, Reynolds HY, eds. Immunologic and infectious reactions in the lung. New York: Dekker, 1976: 289–332.Google Scholar
  6. 6.
    Schatz M, Wasserman S, Patterson R. Eosinophils and 26. immunologic lung disease. Med Clin North Am 1981; 65: 1055–1071.PubMedGoogle Scholar
  7. 7.
    Nadel JA. Inflammation and asthma. J Allergy Clin Immunol 1984; 73: 651–653. 27.Google Scholar
  8. 8.
    McFadden ER Jr. Pathogenesis of asthma. J Allergy Clin Immunol 1984; 73: 413–424.PubMedCrossRefGoogle Scholar
  9. 9.
    McFadden ER Jr. Exertional dyspnea and cough as pre- 28. ludes to acute attacks of bronchial asthma. N Engl J Med 1975; 292: 555–559. 29.Google Scholar
  10. 10.
    Corrao WM, Braman SS, Irwin SS. Chronic cough as the sole presenting manifestation of bronchial asthma. 30. N Engl J Med 1979; 300: 633–637.PubMedCrossRefGoogle Scholar
  11. 11.
    Ishizaka T. Analysis of triggering events in mast cells for immunoglobulin E-mediated histamine release. J Allergy Clin Immunol 1981; 67: 90–92. 31.Google Scholar
  12. 12.
    Ende N, Grizzanti JN, Qrsi VO, Safirstein BH, Reichman L, Baturay-Smith N. Antilung antibodies in asthma. Am J Clin Pathol 1982; 78: 758–761. 32.Google Scholar
  13. 13.
    Casparay FA, Feimann EL, Field EJ. Lymphocyte sensitization in asthma with special reference to the nature and identity of intrinsic form. Br Med J 1973; 1: 15–16. 33.Google Scholar
  14. 14.
    Austin KF, Orange RP. Bronchial asthma; the possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute chronic disease. Am Rev Respir Dis 1975; 112: 423–436. 34.Google Scholar
  15. 15.
    Middleton E Jr, Atkins FM, Fanning M, Georgitis JW. Cellular mechanisms in the pathogenesis and pathophysiology of asthma. Med Clin North Am 35. 1981; 65: 1013–1031.Google Scholar
  16. 16.
    Huber HL, Koessler KK. The pathology of asthma. Arch Intern Med 1922; 30: 689–760. 36.Google Scholar
  17. 17.
    Houston JC, de Nevasquez S, Trounce JR. A clinical and pathological study of fatal cases of status asthmaticus. 37. Thorax 1953; 8: 207–213.PubMedCrossRefGoogle Scholar
  18. 18.
    Messer JW, Peters GA. Causes of death and pathologic findings in 304 cases of bronchial asthma. Dis Chest 38. 1960; 38: 616–624.Google Scholar
  19. 19.
    Dunnill MS. The pathology of asthma with special reference to changes in the bronchial mucosa. J Clin Pathol 39. 1960; 13: 27–33.Google Scholar
  20. 20.
    Dunnill MS, Massarella GR, Anderson JA. A cómparison of the quantitative anatomy of the bronchi in normal 40. subjects, in status asthmaticus, in chronic bronchitis and in emphysema. Thorax 1969; 24: 176–179. 41.Google Scholar
  21. 21.
    Dunnill MS. Pathology of asthma. In: Middleton E Jr, Reed CE, Ellis EF, eds. Allergy: Principles and practice. St Louis: Mosby, 1978: 678–686. 42.Google Scholar
  22. 22.
    Dunnill MS. Pulmonary pathology. Edinburgh: Churchill-Livingtone, 1982: 50–66.Google Scholar
  23. 23.
    Gough J. Correlation of radiological and pathological changes in some diseases of the lung. Lancet 1955; 1: 161–162.CrossRefGoogle Scholar
  24. 24.
    Bohrod M. Pathologic manifestations of allergic and related mechanisms in diseases of the lungs. Int Arch Allergy Appl Immunol 1958; 13: 39–60.PubMedCrossRefGoogle Scholar
  25. 25.
    Callerame ML, Condemi JJ, Bohrod MG, Vaughan JH. Immunologic reactions of bronchial tissue in asthma. N Engl J Med 1971; 284: 459–464.PubMedCrossRefGoogle Scholar
  26. 26.
    Callerame ML, Condemi JJ, Ishizaka K, Johansson SGO, Vaughan JH. Immunoglobulins in bronchial tissues from patients with asthma, with special reference to immunoglobulin E. J Allergy 1971; 47: 187–197.Google Scholar
  27. 27.
    McCarter JH, Vazquez JJ. The bronchial basement membrane in asthma. Arch Pathol Lab Med 1966; 82: 328335.Google Scholar
  28. 28.
    Barton AD, Lourenco RV. Bronchial secretions and mucociliary clearance. Arch Intern Med 1973;131:140–144. Burgi H. Fibre systems in sputum. Bull Physiopathol Respir 1973; 9: 191–196.Google Scholar
  29. 29.
    Hulbert WC, Walker DC, Jackson A, Hogg JC. Airway permeability to horseradish peroxidase in guinea pigs. The repair phase after injury by cigarette smoke. Am Rev Respir Dis 1981; 123: 320–326.PubMedGoogle Scholar
  30. 30.
    Sanerkin NG, Evan DMD. The sputum in bronchial asthma: pathognomic patterns. J Pathol Bacteriol 1965; 89: 535–541.PubMedCrossRefGoogle Scholar
  31. 31.
    Jelihovsky T. The structure of bronchial plugs in mucoid impaction, bronchocentric granulomatosis and asthma. Histopathology 1983; 7: 153–167.PubMedCrossRefGoogle Scholar
  32. 32.
    Weller PF, Goetzl EJ, Austen KF. Identification of human eosinophil lysophospholipase as the constituent of Charcot-Leyden crystals. Proc Nat! Acad Sci USA. 1980; 77: 7440–7443.CrossRefGoogle Scholar
  33. 33.
    Weller PF, Bach D, Austen KF. Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals. J Immunol 1982; 128: 1346–1349.PubMedGoogle Scholar
  34. 34.
    Ackerman SJ, Weil GJ, Gleich GJ. Formation of Charcot-Leyden crystals by human eosinophils. J Exp Med 1982; 155: 1597–1609.PubMedCrossRefGoogle Scholar
  35. 35.
    Naylor B. The shedding of the mucosa of the bronchial tree in asthma. Thorax 1962; 17: 69–72.PubMedCrossRefGoogle Scholar
  36. 36.
    Cohen RC, Prentice AID. Metaplastic cells in sputum of patients with pulmonary eosinophilia. Tubercle 1959; 40: 44–46.PubMedCrossRefGoogle Scholar
  37. 37.
    Frigas E, Loegering DA, Gleich GJ. Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium. Lab Invest 1980; 42: 35–43.PubMedGoogle Scholar
  38. 38.
    Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol 1986; 77: 527–537.PubMedCrossRefGoogle Scholar
  39. 39.
    Wood DW, Lecks HI. Deaths due to childhood asthma. Are they preventable? Clin Pediatr 1976; 15: 677–687.CrossRefGoogle Scholar
  40. 40.
    Hertzel MR, Clark TJH, Branthwaite MA. Asthma: Analysis of sudden deaths and ventilatory arrests in hospital. Br Med J 1977;1:808–811. Research Committee of the British Thoracic Association. Death from asthma in two regions of England. Br Med J 1982; 285: 1251–1255.Google Scholar
  41. 41.
    Weller PF, Bach D, Austen KF. Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals. J Immunol 1982; 128: 1346–1349.PubMedGoogle Scholar
  42. 42.
    Ackerman SJ, Weil GJ, Gleich GJ. Formation of Charcot-Leyden crystals by human eosinophils. J Exp Med 1982; 155: 1597–1609.PubMedCrossRefGoogle Scholar
  43. 43.
    Reeder WH, Goodrich BE. Pulmonary infiltration with eosinophilia (PIE syndrome). Ann Intern Med 1952; 36: 1217–1240.PubMedCrossRefGoogle Scholar
  44. 44.
    Liebow AA, Carrington CB. The eosinophilic pneumonias. Medicine (Baltimore) 1969; 48: 251–285.CrossRefGoogle Scholar
  45. 45.
    Löffler W. Zur differential-diagnose der lungeninfiltrierungen, II. Uber fluchtige succedan-infiltrate (mit eosinophile). Beitr Klin Tuberk 1932; 79: 368–382.CrossRefGoogle Scholar
  46. 46.
    Von Meyenburg H. Das eosinophile lungeninfiltrat. Pathologische anatomie and pathogenese. Schweiz Med Wochenschr 1942; 30: 809–811.Google Scholar
  47. 47.
    Gelpi AP, Mustafa M. Ascaris pneumonia. Am J Med 1968; 44: 377–389.PubMedCrossRefGoogle Scholar
  48. 48.
    Sprent JFA. On the toxic and allergic manifestations produced by the tissue and fluids of Ascaris; effects on different tissues. J Infect Dis 1949; 84: 221–229.PubMedCrossRefGoogle Scholar
  49. 49.
    Phills JA, Harrold AJ, Whiteman GV, Perelmutter L. Pulmonary infiltrates, asthma, and eosinophilia due to Ascaris suum infestation in man. N Engl J Med 1972; 286: 965–1000.PubMedCrossRefGoogle Scholar
  50. 50.
    Rose GA, Spencer H. Polyarteritis nodosa. Q J Med 1957; 26: 43–81.PubMedGoogle Scholar
  51. 51.
    Weingarten RJ. Tropical eosinophilia. Lancet 1943; 1: 103–105.CrossRefGoogle Scholar
  52. 52.
    Webb JKG, Job CK, Gault EW. Tropical eosinophilia, demonstration of microfilariae in lung, liver and lymph-nodes. Lancet 1960; 1: 835–842.PubMedCrossRefGoogle Scholar
  53. 53.
    Danaraj TJ, Pacheco G, Shanmugaratnam K, Beaver PC. The etiology and pathology of eosinophilic lung (tropical eosinophilia). Am J Trop Med Hyg 1966; 15: 183–189.PubMedGoogle Scholar
  54. 54.
    Beaver PC. Filariasis without microfilaremia. Am J Trop Med Hyg 1970; 19: 181–189.PubMedGoogle Scholar
  55. 55.
    Donahue DL. Tropical eosinophilia, an etiologic inquiry. N Engl J Med 1963; 269: 1357–1364.CrossRefGoogle Scholar
  56. 56.
    Parish RA. Intestinal parasites in Southeast Asian refugee children. West J Med 1985; 143: 47–49.PubMedGoogle Scholar
  57. 57.
    Carrington CB, Addington WW, Goff AM et al. Chronic eosinophilic pneumonia. N Engl J Med 1969; 280: 787–798.PubMedCrossRefGoogle Scholar
  58. 58.
    Pearson DJ, Rosenow EC. Chronic eosinophilic pneumonia (Carrington’s), a follow-up study. Mayo Clin Proc 1978; 55: 73–78.Google Scholar
  59. 59.
    Hennell H, Sussman ML. The roentgen features of eosinophilic infiltrations in the lungs. Radiology 1945; 44: 328–334.Google Scholar
  60. 60.
    Gaensler EA, Carrington CB. Peripheral opacities in chronic eosinophilic pneumonia: the photographic negative of pulmonary edema. AJR 1977; 128: 1–13.PubMedCrossRefGoogle Scholar
  61. 61.
    Bedrossian CWM, Greenberg SD, Williams LJ Jr. Ultra-structure of the lung in Loeffler’s pneumonia. Am J Med 1975; 58: 438–443.PubMedCrossRefGoogle Scholar
  62. 62.
    Kanner RE, Hammar SP. Chronic eosinophilic pneumonia; ultrastructural evidence of marked immunoglobulin production plus macrophagic ingestion of eosinophils and eosinophilic lysosomes leading to intracytoplasmic Charcot-Leyden crystals. Chest 1977; 71: 95–98.PubMedCrossRefGoogle Scholar
  63. 63.
    Urschel HC Jr, Paulson DL, Shaw RR. Mucoid impaction of the bronchi. Ann Thorac Surg 1966; 2: 1–16.PubMedCrossRefGoogle Scholar
  64. 64.
    Katzenstein AL, Liebow AA, Friedman PJ. Bronchocentric granulomatosis, mucoid impaction, and hypersensitivity reaction to fungi. Am Rev Respir Dis 1975; 111: 497–537.PubMedGoogle Scholar
  65. 65.
    Shaw RR. Mucoid impaction of the bronchi. J Thorac Surg 1951; 22: 149–163.PubMedGoogle Scholar
  66. 66.
    Sanerkin NG, Seal RME, Leopold JG. Plastic bronchitis, mucoid impaction of the bronchi and allergic bronchopulmonary aspergillosis, and their relationship to bronchial asthma. Ann Allergy 1966; 24: 586–594.PubMedGoogle Scholar
  67. 67.
    Bettman M. Report of a case of fibrinous bronchitis with a review of the literature. Am J Med Sci 1902; 123: 304–329.CrossRefGoogle Scholar
  68. 68.
    Leggat PO. Plastic bronchitis. Dis Chest 1954; 26: 464–473.PubMedCrossRefGoogle Scholar
  69. 69.
    Johnson RS, Sita-Lumsden EG. Plastic bronchitis. Thorax 1960; 15: 325–332.PubMedCrossRefGoogle Scholar
  70. 70.
    Hinson KFW, Moon JH, Plummer NS. Bronchopulmonary aspergillosis; a review and a report of eight new cases. Thorax 1952; 7: 317–333.PubMedCrossRefGoogle Scholar
  71. 71.
    Liebow AA. Pulmonary angiitis and granulomatosis. Am Rev Respir Dis 1973; 108: 1–18.PubMedGoogle Scholar
  72. 72.
    Koss MN, Robinson KG, Hochholzer L. Bronchocentric granulomatosis. Hum Pathol 1981; 12: 632–638.PubMedCrossRefGoogle Scholar
  73. 73.
    Chan-Yeung M, Chase WH, Trapp W, Grzybowski S. Allergic bronchopulmonary aspergillosis: clinical and pathologic study of three cases. Chest 1971; 59: 33–39.PubMedCrossRefGoogle Scholar
  74. 74.
    Warnock ML, Fennessy MB, Rippon J. Chronic eosinophilic pneumonia, a manifestation of allergic aspergillosis. Am J Clin Pathol 1974; 62: 73–80.PubMedGoogle Scholar
  75. 75.
    Saldana MJ. Bronchocentric granulomatosis: clinico-pathologic observations in 17 patients. Lab Invest 1979; 40: 281–282.Google Scholar
  76. 76.
    Lee JH, Joihovsky T, Yan K. Bronchocentric granulomatosis: Review of 14 patients. Thorax 1982; 37: 779.Google Scholar
  77. 77.
    Myers JL, Katzenstein A-LA. Granulomatous infection mimicking bronchocentric granulomatosis. Am J Surg Pathol 1986; 10: 317–322.PubMedCrossRefGoogle Scholar
  78. 78.
    Ulbright T, Katzenstein A-LA. Solitary necrotizing granulomas of the lung. Am J Surg Pathol 1980; 4: 13–27.PubMedGoogle Scholar
  79. 79.
    DenHertog RW, Wagenaar Sj Sc, Westermann CJ J. Bronchocentric granulomatosis and pulmonary ecchinococcosis. Am Rev Respir Dis 1982; 125: 344–347.Google Scholar
  80. 80.
    Solomon WR, Burge HP. Aspergillus fumigatus levels in and out of doors in urban air. J Allergy Clin Immunol 1975; 55: 90–91.Google Scholar
  81. 81.
    Slavin RG, Stanczyk DJ, Lonigro AJ, Broun GO. Allergic bronchopulmonary aspergillosis-a North American rarity: clinical and immunologic characteristics. Am J Med 1969; 47: 306–313.PubMedCrossRefGoogle Scholar
  82. 82.
    Hoehne JH, Reed CE, Dickie HA. Allergic bronchopulmonary aspergillosis is not rare. Chest 1973; 63: 177–181.PubMedCrossRefGoogle Scholar
  83. 83.
    Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 1977; 86: 405–414.PubMedCrossRefGoogle Scholar
  84. 84.
    Henderson AH. Allergic aspergillosis; review of 32 cases. Thorax 1968; 12: 501–512.CrossRefGoogle Scholar
  85. 85.
    Scadding JG. Eosinophilic infiltrations of the lungs in asthmatics. Proc R Soc Med 1971; 64: 381–392.PubMedGoogle Scholar
  86. 86.
    McCarthy DS, Pepys J. Allergic broncho-pulmonary aspergillosis, clinical immunology: (1) clinical features. Clin Allergy 1971;1:261–286.Google Scholar
  87. 87.
    McCarthy DS, Pepys J. Allergic bronchopulmonary aspergillosis, clincial immunology: (2) skin, nasal and bronchial tests. Clin Allergy 1971;1:415–432.Google Scholar
  88. 88.
    McCarthy DS, Simon G, Hargreave FE. The radiological appearances in allergic bronchopulmonary aspergillosis. Clin Radiol 1970;21:366–375.Google Scholar
  89. 89.
    McCarthy DS, Bronchiectasis in allergic bronchopulmonary aspergillosis. Proc R Soc Med 1968;61:503–506.Google Scholar
  90. 90.
    Safirstein BH, D’Souza MF, Simon G, Tai EHG, Pepys J. Five-year follow-up of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis 1973;108:450–459.Google Scholar
  91. 91.
    McCarthy DS, Pepys J. Cryptogenic pulmonary eosinophilias. Clin Allergy 1973;3:339–351.Google Scholar
  92. 92.
    Scadding JG. The bronchi in allergic aspergillosis. Scand J Respir Dis 1965;48:372–377.Google Scholar
  93. 93.
    Imbeau SA, Nichols D, Flaherty D, et al. Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 1978; 62:243–255.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • David H. Dail

There are no affiliations available

Personalised recommendations