Mycoplasmal, Rickettsial, and Chlamydial Infections

  • John A. Blackmon


Several organisms other than viruses cause pneumonias that are characterized to some degree by interstitial cellular reactions. These are the rickettsiae, chlamydiae, and mycoplasmas. Although differing greatly in severity, these diseases share some clinical and pathologic features. Since these organisms are difficult to culture, the diagnosis is most often established by immunologic methods. These methods include both serologic assays and direct immunofluorescent or immunoperoxidase studies on tissues.


Chlamydia Trachomatis Alveolar Epithelial Cell Chlamydial Infection Mycoplasma Pneumoniae Viral Pneumonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Eaton MD, Meiklejohn G, Van Herick W. Studies on the etiology of primary atypical pneumonia. A filterable agent transmissible to cotton rats, hampsters, and chick embryos. J Exp Med 1944; 79: 649–668.PubMedCrossRefGoogle Scholar
  2. 2.
    Chanock RM, Hayflick L, Barile MF. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci USA 1962; 48: 41–49.PubMedCrossRefGoogle Scholar
  3. 3.
    Chanock RM, Dienes L, Eaton MD, et al. Mycoplasma pneumoniae: proposed nomenclature for atypical pneumonia organism (Eaton agent). Science 1963; 140: 662.PubMedCrossRefGoogle Scholar
  4. 4.
    Hayflick L, Chanock RM. Mycoplasma species of man. Bacteriol Rev 1965; 29: 185–221.PubMedGoogle Scholar
  5. 5.
    Chanock RM. Mycoplasma infections of man. N Engl J Med 1965;273: 1199–1206, 1257–1264.Google Scholar
  6. 6.
    Helms CM, Viner JP, Sturm RH, Renner ED, Johnson W. Comparative features of pneumoccoccal, mycoplasmal, and Legionnaires’ disease pneumonies. Ann Intern Med 1979; 90: 543–547.PubMedCrossRefGoogle Scholar
  7. 7.
    Feckety FR Jr, Caldwell J, Gump D, et al. Bacteria, viruses, and mycoplasmas in acute pneumonia in adults. Am Rev Respir Dis 1971; 104: 499–507.Google Scholar
  8. 8.
    Kohler RB. Antigen detection for the rapid diagnosis of Mycoplasma and Legionella pneumonia. Diagn Microbiol Infect Dis 1986; 4: 47S - 59S.PubMedCrossRefGoogle Scholar
  9. 9.
    Razin S, Gross M, Wormser M, Pollack Y, Glaser G. Detection of mycoplasmas infecting cell cultures by DNA hybridization. In Vitro Cell Dev Biol 1984; 20: 404–408.Google Scholar
  10. 10.
    Murray HW, Masur H, Senterfit LB, Roberts RB. The protean manifestations of Mycoplasma pneumoniae infections in adults. Am J Med 1975; 58: 229–242.PubMedCrossRefGoogle Scholar
  11. 11.
    Koletsky RJ, Weinstein AJ. Fulminant Mycoplasma pneumoniae infection. Report of a fatal case, and review of the literature. Am Rev Respir Dis 1980; 122: 491–496.PubMedGoogle Scholar
  12. 12.
    Naftalin JM, Wellisch G, Kahana Z, Diengott D. Mycoplasma pneumoniae septicemia. JAMA 1974; 228: 565.PubMedCrossRefGoogle Scholar
  13. 13.
    Parker F, Jolliffe LS, Finland M. Primary atypical pneumonia. Arch Pathol Lab Med 1947; 44: 581–608.Google Scholar
  14. 14.
    Rollins S, Colby T, Clayton F. Open lung biopsy in Mycoplasma pneumoniae pneumonia. Arch Pathol Lab Med 1986; 110: 34–41.PubMedGoogle Scholar
  15. 15.
    Maisel JC, Babbitt LH, John TJ. Fatal Mycoplasma pneumoniae infection with isolation of organisms from lung. JAMA 202; 1967: 287–290.PubMedCrossRefGoogle Scholar
  16. 16.
    Goudie BM, Kerr MR, Johnson RN. Mycoplasma pneumonia complicated by bronchiectasis. J Infect 1983; 7: 151–152.PubMedCrossRefGoogle Scholar
  17. 17.
    Whyte KF, Williams GR. Bronchiectasis after mycoplasma pneumonia. Thorax 1984; 39: 390–391.PubMedCrossRefGoogle Scholar
  18. 18.
    Levine DP, Lerner AM. The clinical spectrum of Mycoplasma pneumoniae infections. Med Clin North Am 1978; 62: 961–978.PubMedGoogle Scholar
  19. 19.
    Donohue IF: Lower respiratory tract involvement in Rocky Mountain spotted fever. Arch Intern Med 1980; 140: 223–227.PubMedCrossRefGoogle Scholar
  20. 20.
    Oster CN, Burke DS, Kenyon RH, Ascher MS, Harber P, Pedersen CE. Laboratory-acquired Rocky Mountain spotted fever. N Engl J Med 1977; 297: 859–863.PubMedCrossRefGoogle Scholar
  21. 21.
    Walker DH, Crawford CG, Cain BG. Rickettsia) infection of the pulmonary microcirculation: the basis for interstitial pneumonitis in Rocky Mountain spotted fever. Hum Pathol 1980; 11: 263–272.PubMedCrossRefGoogle Scholar
  22. 22.
    Hand WL, Miller JB, Reinarz JA, Sanford JP. Rocky Mountain spotted fever. A vascular disease. Arch Intern Med 1970; 125: 879–882.PubMedCrossRefGoogle Scholar
  23. 23.
    Moe JB, Ruch GL, Kenyon RH, Burek JD, Stookey JL. Pathology of experimental Rocky Mountain spotted fever in Rhesus monkeys. Vet Pathol 1976; 13: 69–77.PubMedGoogle Scholar
  24. 24.
    Walker DH, Cain BG. A method for specific diagnosis of Rocky Mountain spotted fever on fixed, paraffin-embedded tissue by immunofluorescence. J Infect Dis 1978; 137: 206–209.PubMedCrossRefGoogle Scholar
  25. 25.
    Lillie RD, Perrin TL, Armstrong C. An institutional outbreak of pneumonitis. III. Histopathology in man and Rhesus monkeys in the pneumonitis due to the virus of “Q” fever. Public Health Rep 1941; 56: 149–155.CrossRefGoogle Scholar
  26. 26.
    Whittick JW. Necropsy findings in a case of Q fever in Britain. Br Med J 1950; 1: 979–980.PubMedCrossRefGoogle Scholar
  27. 27.
    Schachter J. Chlamydial infection. N Engl J Med 1978; 298:428–435, 490–495, 540–549.Google Scholar
  28. 28.
    Lillie RD. The pathology of psittacosis in man. NIH Bull No. 161, 1933: 1–45.Google Scholar
  29. 29.
    Thomson AP, Hillier WT. Psittacosis. A further account of cases of human infection. Lancet 1930; 1: 396–402.CrossRefGoogle Scholar
  30. 30.
    Binford CH, Hauser GH. An epidemic of a severe pneumonitis in the Bayou region of Louisiana. III. Pathological observations. Public Health Rep 1944; 59: 1363–1374.CrossRefGoogle Scholar
  31. 31.
    Arth C, Von Schmidt B, Grossman M, Schachter J. Chlamydial pneumonitis. J Pediatr 1978; 93: 447–449.PubMedCrossRefGoogle Scholar
  32. 32.
    Schachter J, Lum L, Gooding CA, Ostler W Pneumonitis following inclusion blennorrhea. J Pediatr 1975; 87: 779780.Google Scholar
  33. 33.
    Beem MO, Saxon EM. Respirator-tract colonization and a distinctive pneumonia syndrome in infants infected with Chlamydia trachomatis. N Engl J Med 1977; 296: 306310.Google Scholar
  34. 34.
    Ito JI Jr, Comess KA, Alexander ER, et al. Pneumonia due to Chlamydia trachomatis in an immunocompromised adult. N Engl J Med 1982; 307: 95–98.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1988

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  • John A. Blackmon

There are no affiliations available

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