Infections in the Intensive Care Unit

  • Gregory J. Rossini
  • Wissam Chatila


Acute bacterial meningitis (ABM) is a life-threatening and severe infection involving the membranes of the central nervous system (CNS). ABM often presents in fulminant fashion with multiple complications and a high fatality rate despite the availability of potent antimicrobial therapy. The annual incidence of ABM is approximately 3.0 cases per 100,000 population in the United States but varies greatly according to risk factors such as geography, race, and gender. Mortality rates also vary according to the same risk factors and depend on the type of invading pathogen, ranging from 6% for Haemophilus influenzae meningitis to 35% for nosocomial meningitis. Currently, two issues dominate the field of ABM: first, the change in epidemiology effected by the introduction of H. influenzae type b vaccine, and second, the emergence of multidrug-resistant Streptococcus pneumoniae as a new pathogen. Recognition of pathogens based on age and prompt initiation of antimicrobial therapy are the cornerstones of ABM management.


Blood Culture Infective Endocarditis Nosocomial Infection Antimicrobial Therapy Nosocomial Pneumonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Gregory J. Rossini
  • Wissam Chatila

There are no affiliations available

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