Abstract
Normal cellular function in the body is critically dependent on oxygen. Therefore, it is important for the body to be able to deliver oxygen to the cells and for the cells to utilize the oxygen once it has arrived. A change in either of these variables could lead to the development of cellular hypoxia and result in end-organ failure and possibly death. In many disease states, changes in oxygen delivery (DO2) and oxygen consumption (\(\dot V\)O2) are noted to occur and may be responsible for the clinical presentation of these patients. Meeting the metabolic demands of the cells is thus an important component of therapy in the critically ill patient.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Suggested Reading
Bihari D, Smithies M, Gimson A, Tinker J. The effect of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 1987; 317: 397–403.
Chittock DR, Ronco JJ, Russell JA. Monitoring of oxygen transport and oxygen consumption. In: Tobin MJ (ed) Principles and Practice of Intensive Care Monitoring. New York: McGraw-Hill, 1997: 317–343.
Gattinoni L, Brazzi L, Paolo P, et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 1995; 333: 1025–1032.
Hotchkiss RS, Karl IE. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 1992; 267: 1503–1513.
Ronco JJ, Fenwick JC, Tweeddale MG, et al. Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans JAMA 1993; 270: 1724–1730.
Shoemaker WC, Montgomery ES, Kaplan E, Elwyn DH. Physiologic patterns in surviving and nonsurviving shock patients. Arch Surg 1973; 106: 630–636.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Crocetti, J., Krachman, S. (2002). Oxygen Content, Delivery, and Uptake. In: Criner, G.J., D’Alonzo, G.E. (eds) Critical Care Study Guide. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3927-5_22
Download citation
DOI: https://doi.org/10.1007/978-1-4757-3927-5_22
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-95164-5
Online ISBN: 978-1-4757-3927-5
eBook Packages: Springer Book Archive