Bleeding Diathesis

  • Ronald Rubin


Normal hemostasis requires an intact interrelating mechanism composed of vascular and tissue components, platelets, and coagulation proteins. Deficiency or disease of any of these components may cause either spontaneous or trauma-related hemorrhage. The intensive care setting, by definition, involves a population that is characterized by multiorgan failure, polypharmacy, and multiple wounds of both accidental or iatrogenic variety. Such pathophysiology significantly stresses even an initially normal hemostatic mechanism. It is not surprising, then, that bleeding is a frequent complication encountered in the intensive care setting. A thorough history, physical findings as well as a broad battery of laboratory tests, often serves to differentiate the different bleeding dyscrasias.


Factor VIII Platelet Function Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Bleeding Time 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ronald Rubin

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