Pathophysiology of the Sepsis Syndromes

  • Michael S. Lagnese
  • David E. Ciccolella


Sepsis results when invasion of the body by microorganisms (including bacteria, fungi, viruses, and parasites) causes alterations in the normal homeostatic balance maintained by the human host in health. Patients with sepsis or septic shock may present with a constellation of variable symptoms and signs including fever or low body temperature, tachypnea, tachycardia, low blood pressure, low urine output, mental status changes, and multiple laboratory abnormalities such as high white blood cell counts, hyperglycemia, and hypoxemia. The number and severity of these clinical manifestations represent a spectrum of clinical conditions, which may progress along a disease continuum from sepsis to more severe sepsis and septic shock. The frequency of these clinical conditions is rising as a result of changing population risk factors, and the mortality rate for severe sepsis and septic shock has remained high, ranging between 40% and 60%.


Tumor Necrosis Factor Septic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Septic Patient 
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Suggested Reading

  1. Light RB. Sepsis syndrome. In: Hall JB, Schmidt GA, Wood LDH (eds) Sepsis Syndrome in Principles of Critical Care. New York: McGraw-Hill, 1992: 645–655.Google Scholar
  2. Marik PE, Varon J. The hemodynamic derangements in sepsis. Implications for treatment strategies. Chest 1998; 114: 854–860.PubMedCrossRefGoogle Scholar
  3. Schlichtig R. Oxygen delivery and consumption in critical illness. In: Civetta JM, Taylor RW, Kirby RR (eds) Oxygen Delivery and Consumption in Critical Illness in Critical Care, 3rd ed. Baltimore: Williams and Wilkins, 1997: 337–342.Google Scholar
  4. Wheeler AP, Bernard GR. Treating patients with severe sepsis N Engl J Med 1999; 340: 207–214.Google Scholar
  5. Zimmerman JL, Taylor RW. Sepsis and septic shock. In: Civetta JM, Taylor RW, Kirby RR (eds) Sepsis and Septic Shock in Critical Care, 3rd ed. Baltimore: Williams and Wilkins, 1997: 405–412.Google Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Michael S. Lagnese
  • David E. Ciccolella

There are no affiliations available

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