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Insulin Secretion in Type II Diabetes Mellitus

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Clinical Research in Diabetes and Obesity

Part of the book series: Contemporary Biomedicine ((CB,volume 15))

Abstract

Noninsulin-dependent diabetes mellitus (NIDDM) is characterized by both impaired insulin secretion and action (1). Insulin secretion is abnormal in first-degree relatives of patients with NIDDM with normal (2) or abnormal (3) glucose tolerance. This implies that defective insulin secretion is present early and plays a primary role in the pathogenesis of NIDDM. Since it is clear that there is a molecular genetic basis for NIDDM, the question arises regarding whether the mutations that predispose an individual to NIDDM are related to insulin action or insulin secretion.

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Authors
  1. Yogish C. Kudva
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  2. Peter C. Butler
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Editors and Affiliations

  1. Veteran’s Affairs Medical Center, Denver, CO, USA

    Boris Draznin

  2. Mayo Clinic, Rochester, MN, USA

    Robert Rizza

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Kudva, Y.C., Butler, P.C. (1997). Insulin Secretion in Type II Diabetes Mellitus. In: Draznin, B., Rizza, R. (eds) Clinical Research in Diabetes and Obesity. Contemporary Biomedicine, vol 15. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-3906-0_7

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  • DOI: https://doi.org/10.1007/978-1-4757-3906-0_7

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