Genetics of Noninsulin-Dependent Diabetes Mellitus (NIDDM)

  • Henning Beck-Nielsen
  • Allan Vaag
  • Kirsten Ohm Kyvik
Part of the Contemporary Biomedicine book series (CB, volume 15)


Noninsulin-dependent diabetes mellitus (NIDDM) or type II diabetes is a serious and fast-growing disease affecting about 5–10% of the adults in the Western world (1). NIDDM is preceded by impaired glucose tolerance (IGT), which affects about 25% of the population over 50 yr of age—a disease with nearly as high morbidity and mortality rate as NIDDM—despite “normal” fasting plasma glucose values (2). Both IGT and NIDDM result in 200–300% increased mortality rates, mainly from myocardial infarction (1). Therefore, the NIDDM syndrome—from the early stages to the fulminant hyperglycemic state—is a challenge for all clinicians.


Insulin Resistance Insulin Secretion Impaired Glucose Tolerance Normal Glucose Tolerance Hepatic Glucose Production 
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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Henning Beck-Nielsen
  • Allan Vaag
  • Kirsten Ohm Kyvik

There are no affiliations available

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