Metabolic Parameters and Energy Expenditure Before and After Weight Loss
Much clinical research in diabetes has concentrated on weight loss, since obesity and weight gain are such important risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and weight loss decreases this risk (1). Also, since both obesity and NIDDM are independent risk factors for cardiovascular disease (2–4) and since obesity predisposes to NIDDM and complicates existing disease (1,3), it is universally accepted that the initial treatment of an obese diabetic patient is dietary management (5),with specific emphasis on weight reduction. Several studies have demonstrated that weight loss leads to improvement in all metabolic measurements, including plasma glucose, HbA1C, insulin secretion and responsiveness, and lipid levels (3). Blood pressure also improves (3).
KeywordsObese Subject Obese Woman Lean Body Mass Total Energy Expenditure Rest Metabolic Rate
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