This chapter considers the normal macroscopic, microscopic, and ultrastructural morphology of the human ovary and its hormonal function. Since the anatomy and function of the ovary vary considerably at different stages in a woman’s life, these aspects are considered during adulthood, childhood, and after the menopause.


Corpus Luteum Primordial Follicle Theca Cell Human Ovary Atretic Follicle 
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  1. 1.
    Adams EC, Hertig AT (1969) Studies on the human corpus luteum. I. Observations on the ultrastructure of development and regression of the luteal cells during the menstrual cycle. J Cell Biol 41: 696–715PubMedCrossRefGoogle Scholar
  2. 2.
    Adams EC, Hertig AT (1969) Studies on the human corpus luteum. II. Observations on the ultrastructure of luteal cells during pregnancy. J Cell Biol 41: 716–735PubMedCrossRefGoogle Scholar
  3. 3.
    Aiman J, Fornery JP, Parker R Jr (1986) Secretion ofandrogens and estrogens by normal and neoplastic ovaries in postmenopausal women. Obstet Gynecol 68: 1–5PubMedCrossRefGoogle Scholar
  4. 4.
    Al-Timimi A, Buckley CH, Fox H (1985) An immunohis-tochemical study of the incidence and significance of sex steroid hormone binding sites in normal and neoplastic human ovarian tissue. Int J Gynecol Pathol 4: 24–41PubMedCrossRefGoogle Scholar
  5. 5.
    Ayyagari RR, Khan-Dawood FS (1987) Human corpus luteum: Presence of epidermal growth factor receptors and binding characteristics. Am J Obstet Gynecol 156: 942–946PubMedGoogle Scholar
  6. 6.
    Baca M, Zamboni L (1967) The fine structure of the human follicular oocyte. J Ultrastruct Res 19: 354–381PubMedCrossRefGoogle Scholar
  7. 7.
    Balboni GC (1983) Structural changes: Ovulation and luteal phase. In: Serra GB (ed) The Ovary. New York, Raven Press, pp 123–141Google Scholar
  8. 8.
    Barad DH, Ryan KJ, Elkind-Hirsch K, Makris A (1988) Immunoreactive substance P in the human ovary. Am J Obstet Gynecol 159: 242–246PubMedGoogle Scholar
  9. 9.
    Barbieri RL, Makris A, Randall RW, et al (1986) Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 62: 904–910PubMedCrossRefGoogle Scholar
  10. 10.
    Bassis ML (1956) Pseudodeciduosis. Am J Obstet Gynecol 72: 1029–1037PubMedGoogle Scholar
  11. 11.
    Benjamin E, Law S, Bobrow LG (1987) Intermediate filaments cytokeratin and vimentin in ovarian sex cord-stromal tumours with correlative studies in adult and fetal ovaries. J Pathol 152: 253–263PubMedCrossRefGoogle Scholar
  12. 12.
    Bersch W, Alexy E, Heuser HP, Staemmler HJ (1973) Ectopic decidua formation in the ovary (so-called deciduoma). Virch Archiv A (Pathol Anat) 360: 173–177CrossRefGoogle Scholar
  13. 13.
    Blaustein A (1984) Peritoneal mesothelium and ovarian surface epithelial cells—shared characteristics. Int J Gynecol Pathol 3: 361–375PubMedCrossRefGoogle Scholar
  14. 14.
    Blaustein A, Lee H (1979) Surface cells of the ovary and pelvic peritoneum: A histochemical and ultrastructural comparison. Gynecol Oncol 8: 34–43PubMedCrossRefGoogle Scholar
  15. 15.
    Bloom W, Fawcett DW (1975) A Textbook of Histology. Tenth Edition. Philadelphia, W. B. Saunders Co.Google Scholar
  16. 16.
    Bomsel-Helmreich O, Gougeon A, Thebault A, et al (1979) Healthy and atretic human follicles in the preovulatory phase: differences in evolution of follicular morphology and steroid content of follicular fluid. J Clin Endocrinol Metab 48: 686–694PubMedCrossRefGoogle Scholar
  17. 17.
    Boss JH, Scully RE, Wegner KH, Cohen RB (1965) Structural variations in the adult ovary—clinical significance. Obstet Gynecol 25: 747–763PubMedGoogle Scholar
  18. 18.
    Bransilver BR, Ferenczy A, Richart RM (1974) Brenner tumors and Walthard cell nests. Arch Pathol Lab Med 98: 76–86Google Scholar
  19. 19.
    Centola GM (1983) Structural changes: Follicular development and hormonal requirements. In: Serra GB (ed). The Ovary. New York, Raven Press, pp 95–111Google Scholar
  20. 20.
    Centola GM (1983) Structural changes: Atresia. In: Serra GB (ed) The Ovary. New York, Raven Press, pp 113–122Google Scholar
  21. 21.
    Chang RJ, Judd HL (1981) The ovary after menopause. Clin Obstet Gynaecol 24: 181–191CrossRefGoogle Scholar
  22. 22.
    Charpin C, Bhan AZ, Zurawski VR Jr, Scully RE (1982) Carcinoembryonic antigen (CEA) and carbohydrate determinant 19–9 (CA19–9) localization in 121 primary and metstatic ovarian tumors: An immunohistochemical study with the use of monoclonal antibodies. Int J Gynecol Pathol 1: 231–245PubMedCrossRefGoogle Scholar
  23. 23.
    Clement PB, Young RH, Scully RE (1988) Ovarian granulosa cell proliferations of pregnancy: A report of nine cases. Hum Pathol 19: 657–662PubMedCrossRefGoogle Scholar
  24. 24.
    Cordon-Cardo C, Mattes MJ, Melamed MR, et al (1985) Immunopathologic analysis of a panel of mouse monoclonal antibodies reacting with human ovarian carcinomas and other human tumors. Int J Gynecol Pathol 4: 121–130PubMedCrossRefGoogle Scholar
  25. 25.
    Corner GW Jr (1956) The histological dating of the human corpus luteum of menstruation. Am J Anat 98: 377–401PubMedCrossRefGoogle Scholar
  26. 26.
    Crisp TM, Dessouky DA, Denys FR (1970) The fine structure of the human corpus luteum of early pregnancy and during the progestational phase of the menstrual cycle. Am J Anat 127: 37–70PubMedCrossRefGoogle Scholar
  27. 27.
    Crowley WF (1986) Progesterone antagonism. N Engl J Med 315: 1607–1608PubMedCrossRefGoogle Scholar
  28. 28.
    Croxatto, H., Ortiz M, Croxatto HB (1980) Correlation between histologic dating of human corpus luteum and the luteinizing hormone peak-biopsy interval. Am J Obstet Gynecol 136: 667–670PubMedGoogle Scholar
  29. 29.
    Curtis EM (1962) Normal ovarian histology in infancy and childhood. Obstet Gynecol 19: 444–454PubMedGoogle Scholar
  30. 30.
    Czernobilsky B, Moll R, Franke WW, et al (1984) Intermediate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis. Pathol Res Pract 179: 31–37PubMedCrossRefGoogle Scholar
  31. 31.
    Czernobilsky B, Moll R, Levy R, Franke WW (1985) Coexpression of cytokeratin and vimentin filaments in mesothelial, granulosa and rete ovarii cells of the human ovary. Eur J Cell Biol 37: 175–190PubMedGoogle Scholar
  32. 32.
    Czernobilsky B, Shezen E, Lifschitz-Mercer B, et al (1989) Alpha smooth muscle actin (alpha-SM actin) in normal human ovaries, in ovarian stromal hyperplasia and in ovarian neoplasms. Virchows Arch [B] 57: 55–61CrossRefGoogle Scholar
  33. 33.
    Deane HW, Lobel BL, Romney SL (1962) Enzymic histochemistry of normal human ovaries of the menstrual cycle, pregnancy, and the early puerperium. Am J Obstet Gynecol 83: 281–294PubMedGoogle Scholar
  34. 34.
    Dekel N, David MP, Yedwab GA, Kraicer PF (1977) Follicular development during late pregnancy. Int J Fertil 22: 24–29PubMedGoogle Scholar
  35. 35.
    Dennefors BL, Janson PO, Knutsson F, Hamberger L (1980) Steroid production and responsiveness to gonadotropin in isolated stromal tissue of human postmenopausal ovaries. Am J Obstet Gynecol 136: 997–1002PubMedGoogle Scholar
  36. 36.
    Dennefors BL, Janson PO, Hamberger L, Knutsson F (1982) Hilus cells from human postmenopausal ovaries: gonadotrophin sensitivity, steroid and cyclic AMP production. Acta Obstet Gynecol Scand 61: 413–416PubMedCrossRefGoogle Scholar
  37. 37.
    Dyer CA, Erickson GF (1985) Norepinephrine amplifies human chorionic gonadotropin-stimulated androgen biosynthesis by ovarian theca-interstitial cells. Endocrinology 116: 1645–1652PubMedCrossRefGoogle Scholar
  38. 38.
    Eichner E, Bove ER (1954) In vivo studies on the lymphatic drainage of the human ovary. Obstet Gynecol 3: 287–297PubMedGoogle Scholar
  39. 39.
    Erickson GF (1978) Normal ovarian function. Clin Obstet Gynecol 21: 31–52PubMedCrossRefGoogle Scholar
  40. 40.
    Feinberg R, Cohen RB (1965) A comparative histochemical study of the ovarian stromal lipid band, stromal theca cell, and normal ovarian follicular apparatus. Am J Obstet Gynecol 92: 958–969Google Scholar
  41. 41.
    Ferenczy A, Richart RM (1974) Female reproductive system: Dynamics of scan and transmission electron microscopy. New York, Wiley amp; Sons.Google Scholar
  42. 42.
    Futterweit W (1985) In: Polycystic Ovarian Disease. Clinical Perspectives in Obstetrics and Gynecology. New York, Springer-Verlag.Google Scholar
  43. 43.
    Gardner GH, Greene RR, Peckham B (1957) Tumors of the broad ligament. Am J Obstet Gynecol 73: 536–555PubMedGoogle Scholar
  44. 44.
    Gillim SW, Christensen AK, McLennan CE (1969) Fine structure of the human menstrual corpus luteum at its stage of maximum secretory activity. Am J Anat 126: 409–428PubMedCrossRefGoogle Scholar
  45. 45.
    Gougeon A (1981) Frequent occurrence of multiovular follicles and multinuclear oocytes in the adult human ovary. Fertil Steril 35: 417–422PubMedGoogle Scholar
  46. 46.
    Govan ADT (1970) Ovarian follicular activity in late pregnancy. J Endocrinol 48: 235–241PubMedCrossRefGoogle Scholar
  47. 47.
    Green JA, Maqueo M (1965) Ultrastructure of the human ovary. I. The luteal cell during the menstrual cycle. Am J Obstet Gynecol 92: 946–957PubMedGoogle Scholar
  48. 48.
    Green JA, Garcilazo JA, Maqueo M (1967) Ultrastructure of the human ovary. II. The luteal cell at term. Am J Obstet Gynecol 99: 855–863PubMedGoogle Scholar
  49. 49.
    Greenblatt RB, Colle ML, Mahesh VB (1976) Ovarian and adrenal steroid production in the postmenopausal woman. Obstet Gynecol 47: 383–387PubMedGoogle Scholar
  50. 50.
    Grodin JM, Siiteri PK, MacDonald PC (1973) Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab 36: 207–214PubMedCrossRefGoogle Scholar
  51. 51.
    Hameed A, Fox WM, Kurman RJ, et al. (1993) Perform expression in cell mediated luteolysis: Evidence for highly selective recruitment of CD8+ T-lymphocytes in vivo (unpublished data)Google Scholar
  52. 52.
    Herr JC, Heidger PM Jr, Scott JR, et al (1978) Decidual cells in the human ovary at term. I. Incidence, gross anatomy and ultrastructural features of merocrine secretion. Am J Anat 152: 7–28PubMedCrossRefGoogle Scholar
  53. 53.
    Hertig AT (1964) Gestational hyperplasia of endometrium. A morphologic correlation of ova, endometrium, and corpora lutea during early pregnancy. Lab Invest 13: 1153–1191PubMedGoogle Scholar
  54. 54.
    Hertig AT (1968) The primary human oocyte: Some observations on the fine structure of Balbiani’s vitelline body and the origin of the annulate lamellae. Am J Anat 122: 107–138PubMedCrossRefGoogle Scholar
  55. 55.
    Hertig AT, Adams EC (1967) Studies on the human oocyte and its follicle. I. Ultrastructural and histochemical observations on the primordial follicle stage. J Cell Biol 34: 647–675PubMedCrossRefGoogle Scholar
  56. 56.
    Hidvegi D, Cibils LA, Sorensen K, Hidvegi I (1982) Ultrastructural and histochemical observations of neuroendocrine granules in nonneoplastic ovaries. Am J Obstet Gynecol 143: 590–594PubMedGoogle Scholar
  57. 57.
    Hillier SG (1987) Intrafollicular paracrine function of ovarian androgen. J Steroid Biochem 27: 351–357PubMedCrossRefGoogle Scholar
  58. 58.
    Himelstein-Braw R, Byskov AG, Peters H, Faber M (1976) Follicular atresia in the infant human ovary. J Reprod Fertil 46: 55–59PubMedCrossRefGoogle Scholar
  59. 59.
    Honore LH, O’Hara KE (1979) Ovarian hilus cell heterotopia. Obstet Gynecol 53: 461–464PubMedGoogle Scholar
  60. 60.
    Isola J, Kallioniemi O, Korte J, et al (1990) Steroid receptors and Ki-67 reactivity in ovarian cancer and in normal ovary: Correlation with DNA flow cytometry, biochemical receptor assay, and patient survival. J Pathol 162: 295–301PubMedCrossRefGoogle Scholar
  61. 61.
    Israel SL, Rubenstone A, Meranze DR (1954) The ovary at term. I. Decidua-like reaction and surface cell proliferation. Obstet Gynecol 3: 399–407PubMedGoogle Scholar
  62. 62.
    Jacobowitz D, Wallach EE (1967) Histochemical and chemical studies of the autonomic innervation of the ovary. Endocrinology 81: 1132–1139PubMedCrossRefGoogle Scholar
  63. 63.
    Janko AB, Sandberg EC (1970) Histochemical evidence for the protein nature of the Reinke crystalloid. Obstet Gynecol 35: 493–503PubMedGoogle Scholar
  64. 64.
    Joel RV, Foraker AG (1960) Fate of the corpus albicans: A morphological approach. Am J Obstet Gynecol 80: 314–316PubMedGoogle Scholar
  65. 65.
    Jones GES, Goldberg B, Woodruff JD (1968) Histochemistry as a guide for interpretation of cell function. Am J Obstet Gynecol 100: 76–83PubMedGoogle Scholar
  66. 66.
    Judd HL, Judd GE, Lucas WE, Yen SSC (1974) Endocrine function of the postmenopausal ovary: Concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 39: 1020–1024PubMedCrossRefGoogle Scholar
  67. 67.
    Judd HL, Lucas WE, Yen SSC (1974) Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial carcinoma. Am J Obstet Gynecol 118: 793–798PubMedGoogle Scholar
  68. 68.
    Kabawat SE, Bast RC Jr, Bhan AK, et al (1983) Tissue distribution of coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol 2: 275–285PubMedCrossRefGoogle Scholar
  69. 69.
    Kedzia H (1983) Gonadoblastoma: Structures and background of development. Am J Obstet Gynecol 147: 81–85PubMedGoogle Scholar
  70. 70.
    Kraus FT, Neubecker RD (1962) Luteinization of the ovarian theca in infants and children. Am J Clin Pathol 37: 389–397PubMedGoogle Scholar
  71. 71.
    Laffargue P, Adechy-Benkoel L, Valette C (1968) Ultrastructure du stroma ovarien. Ann Anat Pathol 13: 381–401Google Scholar
  72. 72.
    Laffargue P, Benkoel L, Laffargue F, et al (1978) Ultrastructural and enzyme histochemical study of ovarian hilar cells in women and their relationships with sympathetic nerves. Hum Pathol 9: 649–659PubMedCrossRefGoogle Scholar
  73. 73.
    Lastarna D, Sachdev RK, Babury RA, et al (1990) Immunohistochemical analysis for desmin in normal and neoplastic ovarian stromal tissue. Arch Pathol Lab Med 114: 502–505Google Scholar
  74. 74.
    Lee PA (1983) Ovarian function from conception to puberty: Physiology and disorders. In: Serra GB (ed) The Ovary. New York, Raven Press, pp 177–189Google Scholar
  75. 75.
    LeMaire WJ, Rice BF, Savard K (1968) Steroid hormone formation in the human ovary: V. Synthesis of progesterone in vitro in corpora lutea during the reproductive cycle. J Clin Endocrinol Metab 28: 1249–1256CrossRefGoogle Scholar
  76. 76.
    Longcope C (1971) Metabolic clearance and blood production rates of estrogens in postmenopausal women. Am J Obstet Gynecol 111: 778–781PubMedGoogle Scholar
  77. 77.
    Longcope C, Hunter R, Franz C (1980) Steroid secretion by the postmenopausal ovary. Am J Obstet Gynecol 138: 564–568PubMedGoogle Scholar
  78. 78.
    Loubet R, Loubet A, Leboutet M-J (1984) The ovarian stroma after the menopause: Activity and ageing. In: de Brux J, Gautray J-P (eds) Clinical Pathology of the Ovary. Boston, MTP Press Ltd, pp 119–141CrossRefGoogle Scholar
  79. 79.
    Manivel JC, Dehner LP, Burke B (1988) Ovarian tumorlike structures, biovular follicles, and binucleated oocytes in children: Their frequency and possible pathologic significance. Pediatr Pathol 8: 283–292PubMedCrossRefGoogle Scholar
  80. 80.
    Maqueo M, Goldzieher JW (1966) Hormone-induced alterations of ovarian morphology. Fertil Steril 17: 676–683PubMedGoogle Scholar
  81. 81.
    Mattingly RF, Huang WY (1969) Steroidogenesis of the menopause and postmenopausal ovary. Am J Obstet Gynecol 103: 679–693PubMedGoogle Scholar
  82. 82.
    McLachlan RI, Cohen NL, Vale WW, et al (1989) The importance of luteinizing hormone in the control of inhibin and progesterone secretion by the human corpus luteum. J Clin Endocrinol Metab 68: 1078–1085PubMedCrossRefGoogle Scholar
  83. 83.
    McKay DG, Pinkerton JHM, Hertig AT, Danziger S (1961) The adult human ovary: A histochemical study. Obstet Gynecol 18: 13–39PubMedGoogle Scholar
  84. 84.
    McNatty KP (1978) Follicular determinants of corpus luteum function in the human ovary. In: Channing CP, Marsh JM, Sadler WA (eds). Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology, Vol 112. New York, Plenum Press.Google Scholar
  85. 85.
    McNatty KP (1978) Cyclic changes in antral fluid hormone concentrations in humans. Clin Endocrinol Metab 7: 577–600PubMedCrossRefGoogle Scholar
  86. 86.
    McNatty KP, Makris A, DeGrazia C et al (1979) The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J Clin Endocrinol Metab 49: 687–699PubMedCrossRefGoogle Scholar
  87. 87.
    McNatty KP, Makris A, DeGrazia C, et al (1979) The production of progesterone, androgens, and estrogens by human granulosa cells in vitro and in vivo. J Steroid Biochem 11: 775–799PubMedCrossRefGoogle Scholar
  88. 88.
    McNatty KP, Smith DM, Makris A, et al (1979) The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab 49: 851–860PubMedCrossRefGoogle Scholar
  89. 89.
    McNatty KP, Smith DM, Makris A, et al (1980) The intraovarian sites of androgen and estrogen formation in women with normal and hyperandrogenic ovaries as judged by in vitro experiments. J Clin Endocrinol Metab 50: 755–763PubMedCrossRefGoogle Scholar
  90. 90.
    Merrill JA (1963) The morphology of the prepubertal ovary: Relationship to the polycystic ovary syndrome. South Med J 56: 225–231PubMedCrossRefGoogle Scholar
  91. 91.
    Mestwardt W, Muller O, Brandau H (1978) Structural analysis of granulosa cells from human ovaries in correlation with function. In: Channing CP, Marsh JM, Sadler WA (eds) Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology, Vol 112, New York, Plenum PressGoogle Scholar
  92. 92.
    Miettinen M, Lehto V, Virtanen I (1983) Expression of intermediate filaments in normal ovaries and ovarian epithelial, sex cord-stromal, and germinal tumors. Int J Gynecol Pathol 2: 64–71PubMedCrossRefGoogle Scholar
  93. 93.
    Mikhail G, Allen WM (1967) Ovarian function in human pregnancy. Am J Obstet Gynecol 99: 308–312PubMedGoogle Scholar
  94. 94.
    Mohsin S (1979) The sympathetic innervation of the mammalian ovary. A review of pharmacological and histochemical studies. Clin Exp Pharm Phys 6: 335–354CrossRefGoogle Scholar
  95. 95.
    Nagamani M, Hannigan EV, Van Dinh T, Stuart CA (1988) Hyperinsulinemia and stromal luteinization of the ovaries in postmenopausal women with endometrial cancer. J Clin Endocrinol Metab 67: 144–148PubMedCrossRefGoogle Scholar
  96. 96.
    Nakano R, Shima K, Yamoto M, et al (1989) Binding sites for gonadotropins in human postmenopausal ovaries. Obstet Gynecol 73: 196–200PubMedGoogle Scholar
  97. 97.
    Nelson WW, Greene RR (1953) The human ovary in pregnancy. Int Abs Surg 97: 1–23Google Scholar
  98. 98.
    Nelson WW, Greene RR (1958) Some observations on the histology of the human ovary during pregnancy. Am J Obstet Gynecol 76: 66–89PubMedGoogle Scholar
  99. 99.
    Neunteufel W, Breitenecker G (1989) Tissue expression of CA 125 in benign and malignant lesions of ovary and fallopian tube: A comparison with CA 19-9 and CEA. Gynecol Oncol 32: 297–302PubMedCrossRefGoogle Scholar
  100. 100.
    Nicosia SV (1983) Morphological changes of the human ovary throughout life. In: Serra GB (ed) The Ovary. New York, Raven Press, pp 57–81Google Scholar
  101. 101.
    Nouwen EJ, Hendrix PG, Eerdekens MW, De Broe ME (1987) Tumor markers in the human ovary and its neoplasms. A comparative immunohistochemical study. Am J Pathol 126: 230–242PubMedGoogle Scholar
  102. 102.
    Okamura H, Virutamasen P, Wright KH, Wallach EE (1972) Ovarian smooth muscle in the human being, rabbit, and cat. Am J Obstet Gynecol 112: 183–191PubMedGoogle Scholar
  103. 103.
    Owman C, Rosengren E, Sjoberg N (1967) Adrenergic innervation of the human female reproductive organs: A histochemical and chemical investigation. Obstet Gynecol 30: 763–773PubMedGoogle Scholar
  104. 104.
    Palumbo A, Jones C, Lightman A, et al (1989) Immunohistochemical localization of renin and angiotensin II in human ovaries. Am J Obstet Gynecol 160: 8–14PubMedGoogle Scholar
  105. 105.
    Papadaki L, Beilby JOW (1971) The fine structure of the surface epithelium of the human ovary. J Cell Sci 8: 445–465PubMedGoogle Scholar
  106. 106.
    Pauerstein CJ, Eddy CA, Croxatto HD, et al (1978) Temporal relationships of estrogen, progesterone, and luteinizing hormone levels to ovulation in women and infrahuman primates. Am J Obstet Gynecol 130: 876–886PubMedGoogle Scholar
  107. 107.
    Pedersen PH, Larsen JF (1968) The ultrastructure of the human granulosal lutein cell of the first trimester of gestation. Acta Endocrinol 58: 481–196PubMedGoogle Scholar
  108. 108.
    Pennington GW (1974) The reproductive endocrinology of childhood and adolescence. Clin Obstet Gynaecol 1: 509–531PubMedGoogle Scholar
  109. 109.
    Peters H, Himelstein-Braw R, Faber M (1976) The normal development of the ovary in childhood. Acta Endocrinol 82: 617–630PubMedGoogle Scholar
  110. 110.
    Plentl AA, Friedman EA (1971) Lymphatic System of the Female Genitalia. Philadelphia, W.B. SaundersGoogle Scholar
  111. 111.
    Plotz EJ, Wiener M, Stein AA, Hahn BD (1967) Enzymatic activities related to steroidogenesis in postmenopausal ovaries of patients with and without endometrial carcinoma. Am J Obstet Gynecol 99: 182–197PubMedGoogle Scholar
  112. 112.
    Pryse-Davies J (1974) The development, structure and function of the female pelvic organs in childhood. Clin Obstet Gynaecol 1: 483–508PubMedGoogle Scholar
  113. 113.
    Quagliarello J, Goldsmith L, Steinetz B, et al (1980) Induction of relaxin secretion in nonpregnant women by human chorionic gonadotropin. J Clin Endocrinol Metab 51: 74–77PubMedCrossRefGoogle Scholar
  114. 114.
    Rao CV (1982) Receptors for gonadotropins in human ovaries. Recent Advances in Fertility Research, Part A: Developments in Reproductive Endocrinology 123-135Google Scholar
  115. 115.
    Reagan JW (1950) Ceroid pigment in the human ovary. Am J Obstet Gynecol 59: 433–436Google Scholar
  116. 116.
    Reed MJ, Beranek PA, Ghilchik MW, James VHT (1985) Conversion of estrone to estradiol and estradiol to estrone in postmenopausal women. Obstet Gynecol 66: 361–365PubMedGoogle Scholar
  117. 117.
    Reeves G (1971) Specific stroma in the cortex and medulla of the ovary. Cell types and vascular supply in relation to follicular apparatus and ovulation. Obstet Gynecol 37: 832–844PubMedGoogle Scholar
  118. 118.
    Rice BF, Hammerstein J, Savard K (1964) Steroid hormone formation in the human ovary: II. Action of gonadotropins in vitro in the corpus luteum. J Clin Endocrinol 24: 606–615CrossRefGoogle Scholar
  119. 119.
    Rice BF, Savard K (1966) Steroid hormone formation in the human ovary: IV. Ovarian stromal compartment; formation of radioactive steroids from acetate-1-14C and action of gonadotropins. J Clin Endocrinol 26: 593–609CrossRefGoogle Scholar
  120. 120.
    Rodriguez GC, Berchuk A, Whitaker RS, et al (1991) Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. II. Relationship between receptor expression and response to epidermal growth factor. Am J Obstet Gynecol 164: 745–750PubMedGoogle Scholar
  121. 121.
    Safneck JR, DeSa DJ (1986) Structures mimicking sex cordstromal tumours and gonadoblastomas in the ovaries of normal infants and children. Histopathology 10: 909–920PubMedCrossRefGoogle Scholar
  122. 122.
    Schmidt CL, Black VH, Sarosi P, Weiss G (1986) Progesterone and relaxin secretion in relation to the ultrastructure of human luteal cells in culture: Effects of human chorionic gonadotropin. Am J Obstet Gynecol 155: 1209–1219PubMedGoogle Scholar
  123. 123.
    Schmidt WA (1986) Eosin-induced fluorescence of Reinke crystals. Int J Gynecol Pathol 5: 88–89PubMedCrossRefGoogle Scholar
  124. 124.
    Scully RE (1979) Tumors of the ovary and maldeveloped gonads. In: Atlas of Tumor Pathology, Second Series, Fascicle 16. Armed Forces Institute of Pathology, Washington, D.C.Google Scholar
  125. 125.
    Scully RE (1981) Smooth-muscle differentiation in genital tract disorders. (Editorial) Arch Pathol Lab Med 105: 505–507Google Scholar
  126. 126.
    Scully RE, Cohen RB (1964) Oxidative-enzyme activity in normal and pathologic human ovaries. Obstet Gynecol 24: 667–681PubMedGoogle Scholar
  127. 127.
    Sealey JE, Glorioso N, Itskovitz J, Laragh JH (1986) Prorenin as a reproductive hormone. New form of the renin system. Am J Med 81: 1041–1046PubMedCrossRefGoogle Scholar
  128. 128.
    Shaw JA, Dabbs DJ, Geisinger KR (1992) Sclerosing stromal tumor of the ovary: An ultrastructural and immunohis-tochemical analysis with histogenetic considerations. UltrastrPathol 16: 363–377Google Scholar
  129. 129.
    Shima K, Kitayama S, Nakano R (1987) Gonadotropin binding sites in human ovarian follicles and corpora lutea during the menstrual cycle. Obstet Gynecol 69: 800–806PubMedGoogle Scholar
  130. 130.
    Snowden JA, Harkin PJR, Thornton JG, Wells M (1989) Morphometric assessment of ovarian stromal proliferation—a clinicopathological study. Histopathology 14: 369–379PubMedCrossRefGoogle Scholar
  131. 131.
    Stangel JJ, Richart RM, Okagaki T, Cottral G (1970) Nuclear DNA content of luteinized cells of the human ovary. Am J Obstet Gynecol 108: 543–549PubMedGoogle Scholar
  132. 132.
    Stamp J, Visfeldt J (1974) Ovarian morphology in early and late human pregnancy. Acta Obstet Gynecol Scand 53: 211–218CrossRefGoogle Scholar
  133. 133.
    Sternberg WH (1949) The morphology, androgenic function, hyperplasia, and tumors of the human ovarian hilus cells. Am J Pathol 25: 493–521PubMedGoogle Scholar
  134. 134.
    Sternberg WH, Segaloff A, Gaskill CJ (1953) Influence of chorionic gonadotropin on human ovarian hilus cells (Leydig-like cells). J Clin Endocrinol Metab 13: 139–153PubMedCrossRefGoogle Scholar
  135. 135.
    Tanabe K, Gagliano P, Channing CP, et al (1983) Levels of inhibin-F activity and steroids in human follicular fluid from normal women and women with polycystic ovarian disease. J Clin Endocrinol Metab 57: 24–31PubMedCrossRefGoogle Scholar
  136. 136.
    Tsonis CG, Messinis IE, Templeton AA, et al (1988) Gonadotropic stimulation of inhibin secretion by the human ovary during the follicular and early luteal phase of the cycle. J Clin Endocrinol Metab 66: 915–921PubMedCrossRefGoogle Scholar
  137. 137.
    Valdes-Dapena MA (1967) The normal ovary of childhood. Ann NY Acad Sci 142: 597–613PubMedCrossRefGoogle Scholar
  138. 138.
    Vermeulen A (1976) The hormonal activity of the postmenopausal ovary. J Clin Endocrinol Metab 42: 247–253PubMedCrossRefGoogle Scholar
  139. 139.
    Vijayakumar R, Walters WAW (1987) Ovarian stromal and luteal tissue prostaglandins, 17beta-estradiol, and progesterone in relation to the phases of the menstrual cycle in women. Am J Obstet Gynecol 156: 947–951PubMedGoogle Scholar
  140. 140.
    Visfeldt J, Stamp J (1974) Dating of the human corpus luteum of menstruation using histological parameters. Acta Pathol Microbiol Scand A 82: 137–144PubMedGoogle Scholar
  141. 141.
    Visfeldt J, Stamp J (1975) Histology of the human corpus luteum of early and late pregnancy. Acta Pathol Microbiol Scand A 83: 669–677PubMedGoogle Scholar
  142. 142.
    Weiss G, O’Byrne EM, Steinetz BG (1976) Relaxin: A product of the human corpus luteum of pregnancy. Science 194: 948–949PubMedCrossRefGoogle Scholar
  143. 143.
    Weiss G, O’Byrne Em, Hochman JA, Goldsmith LT, Rifkin I, Steinetz BG (1977) Secretion of progesterone and relaxin by the human corpus luteum at midpregnancy and at term. Obstet Gynecol 50: 679–681PubMedGoogle Scholar
  144. 144.
    Weiss G, Rifkin I (1975) Progesterone and estrogen secretion by puerperal human ovaries. Obstet Gynecol 46: 557–559PubMedGoogle Scholar
  145. 145.
    White RF, Hertig AT, Rock J, Adams E (1951) Histological and histochemical observations on the corpus luteum of human pregnancy with special reference to corpora lutea associated with early normal and abnormal ova. Contrib Embryol 34: 55–74Google Scholar
  146. 146.
    Wiley CA, Esterly JR (1976) Observations on the human corpus luteum: Histochemical changes during development and involution. Am J Obstet Gynecol 125: 514–519PubMedGoogle Scholar
  147. 147.
    Yussman MA, Taymor ML (1970) Semm levels of follicle stimulating hormone and luteinizing hormone and of plasma progesterone related to ovulation by corpus luteum biopsy. J Clin Endocrinol 30: 396–399CrossRefGoogle Scholar
  148. 148.
    Zhang J, Young RH, Arseneau J, Scully RE (1982) Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors)—a clinicopathological analysis of fifty cases. Int J Gynecol Pathol 1: 270–285PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Philip B. Clement

There are no affiliations available

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