Ocular Effects and Clearance of Intravitreal 5-Fluorouracil

  • George W. Blankenship
  • Beth R. Friedland
  • Mark S. Blumenkranz
Part of the FIDIA Research Series book series (FIDIA, volume 2)


Proliferative vitreoretinopathy (PVR) (1) continues to be a major cause of recurrent retinal detachments following scleral buckling procedures. Improved pars plana vitrectomy techniques (2) combined with intravitreal tamponades (3, 4) now permit successful reattachment of many of these cases. Recent studies have found that 5-Fluorouracil (5-FU) markedly reduces the proliferative activity of the fibroblasts and retinal pigment epithelial cells which result in recurrent retinal detachment.


Retinal Detachment Retinal Pigment Epithelial Cell Intravitreal Injection Cystoid Macular Edema Vitreous Cavity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • George W. Blankenship
    • 1
  • Beth R. Friedland
    • 1
  • Mark S. Blumenkranz
    • 1
  1. 1.The Bascom Palmer Eye InstituteUniversity of Miami School of MedicineMiamiUSA

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