Abstract
Animal models have been developed to study intraocular cellular proliferation and retinal detachments, and the influence of various drugs on these processes. Experimental retinal detachments in animal models have been produced with numerous agents. Retinal detachments of rabbit eyes were produced with intravitreal blood injections by Freilich (1), and with different inflammatory agents by Landholm (2). Foulds (3), and Machemer and Norton (4) produced detachments in rabbit and monkey eyes using a combination of iatrogenic retinal holes and Hyaluronidase. Kloti (5) injected plastic beads into the central retinal artery to produce detachments, and Algvere (6) combined embolization of the central retinal artery, occlusion of the vortex veins, and injection of intravitreal Hyaluronidase to produce detachments with proliferative vitreoretinopathy (PVR).
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References
Freilich DB, Lee DF, Freeman HM (1966): Experimental retinal detachment. Arch Ophthal; 76:393.
Landholm WM, Watzke RC (1965): Experimental retinal detachment with a sulphated polysaccharide. Invest Ophthal; 4:42.
Foulds WS (1963): Experimental retinal detachments. Trans Ophthal Soc UK: 83:153.
Machemer R, Norton E WD (1976): Experimental retinal detachment in the owl monkey. 1. Methods of production and clinical picture. Amer J Ophthalmol 66:3–388.
Kloti R (1967): Experimental occlusion of retinal and ciliary vessels in the owl monkeys. 1. Technique and clinical observation of selective embolism of the central retinal artery system. Exp Eye Res. 6:393.
Algvere P (1976): Retinal detachment and pathology following experimental embolization of choroid and retinal circulation. Av Graefes Arch Klin Exp Ophthal 201:123.
Muller-Jensen K, Mandelcorn MS (1975): Membrane formation by autotransplanted retinal pigment epithelium (RPE). Mod Probl Ophthal Vol 15:22, Basel: S Karger.
Machemer R, Laqua R (1975): Pigment epithelium proliferation in retinal detachment (massive periretinal proliferation). Amer J Ophthalmol 80:1.
Algvere P, Kock E (1976): Experimental fibroplasia in the rabbit vitreous. Retinal detachment induced by autologous fibroblasts. Av Grafes Arch Klin Exp Ophthal 99:115.
Blumenkranz M, Ophir A, Claflin AJ, Hajek A (1982): Fluorouracil for the treatment of massive periretinal proliferation. Am J Ophthalmol 94:458.
Fastenberg D, Diddie K, Sorgente N, Ryan S (1982): A comparison of different cellular in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93:559.
Sugita G, Tano Y, Machemer R (1980): Intravitreal autotransplantation of fibroblasts. Amer J Ophthalmol 89:121.
Binder S (1981): Gibt es eine medikamentose Alternative in der Behandlung der massiven periretinalen Proliferation? Klin Mb, Augenheik 179:483.
Kulnig W, Binder S, Riss B, Skorpik C (1984): Inhibition of experimental intraocular pro-liferation with intravitreous 5-Fluorouracil. Ophthalmologica, Basel 88:248.
Bonnet M, Remy C (1982): Auto-immunity against the retina and massive vitreoretinal retrac-tion. Presented during the XIII meeting of the Jules Gonin Club, Cordoba, March 29.
Remy C (1981): Recherche de Pautoimmunité contre la retine dans les décollements retinieus idiopathiques. Etude de 50 cas J Fr Ophthalmol Vol 4, 3:213.
Tano Y, Sugita G, Atrams G, Machemer R (1980): Inhibition of intraocular proliferations with intravitreal corticosteroids. Am J Ophthalmol 89:131.
Tano Y, Chandler E, Machemer R (1980): Treatment of intraocular proliferation with in-travitreal injection of Triamcinolol acetonide. Amer J Ophthalmol 90:810.
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© 1986 Springer-Verlag Berlin Heidelberg
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Binder, S., Skorpik, C., Paroussis, P., Menapace, R. (1986). Inhibition of Experimental Intraocular Proliferation and Retinal Detachment by Various Drugs. In: Blankenship, G.W., Binder, S., Gonvers, M., Stirpe, M. (eds) Basic and Advanced Vitreous Surgery. FIDIA Research Series, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3881-0_71
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DOI: https://doi.org/10.1007/978-1-4757-3881-0_71
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