The Anatomical and Neurochemical Basis of Atropine-Resistant Neocortical Activation

  • C. H. Vanderwolf


The experiments discussed in Chapter 4 suggested the existence of two distinct activating inputs to the neocortex. In 1973 it seemed reasonable to think that a cholinergic component of the ascending reticular activating system was responsible for atropine-sensitive activation while some ascending non­cholinergic system was responsible for atropine-resistant activation. Since there was evidence of various kinds to suggest the involvement of ascending noradrenergic fibres from the locus coeruleus in cortical activation, I suspected that atropine-resistant neocortical activation might be dependent on norepinephrine (noradrenalin).


Monoamine Oxidase Lateral Hypothalamus Slow Wave Activity Spontaneous Motor Activity Serotonin Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes on Chapter 5

  1. 1.
    Detailed presentations of this topic are provided by:Google Scholar
  2. Vanderwolf, C.H. (1988). Cerebral activity and behavior: control by central cholinergic and serotonergic systems. International Review of Neurobiology, 30: 255–340.CrossRefGoogle Scholar
  3. 2.
    Vanderwolf, C.H. (1984). Aminergic control of the electrocorticogram: a progress report. In: A.A. Boulton, G.B. Baker, W.G. Dewhurst, and M. Sandler (eds.) Neurobiology of the trace amines. Clifton, New Jersey, Humana Press, pp. 163–183.CrossRefGoogle Scholar
  4. 3.
    Vanderwolf, C.H., Leung, L.W.S., Baker, G.B., and Stewart, D.J. (1989). The role of serotonin in the control of cerebral activity: studies with intracerebral 5,7-dihydroxytryptamine. Brain Research, 504: 181–191.PubMedCrossRefGoogle Scholar
  5. 4.
    Watson, N.V., Hargreaves, E.L., Penava, D., Eckel, L.A., and Vanderwolf, C.H. (1992). Serotonin-dependent cerebral activation: effects of methiothepin and other serotonergic antagonists. Brain Research, 597: 16–23. A few years later, it became clear that atropine-resistant neocortical activation in urethane anesthetized rats is sensitive to serotonin antagonists that are ineffective in waking rats, indicating that, in some as yet undetermined manner, urethane modifies and increases the effect of serotonergic antagonists. [Dringenburg, H.C., Vanderwolf, C.H., and Hamilton, J.T. (1995). Urethane reduces contraction to 5hydroxytrytamine (5-HT) and enhances the action of the 5-HT antagonist ketanserin on the rat thoracic aortic ring. Journal of Neural Transmission, 101, 183–1931Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • C. H. Vanderwolf
    • 1
  1. 1.University of Western OntarioLondonCanada

Personalised recommendations