Cellular Immunotherapy — Towards Direct DC Activation for Licence to Kill

  • F. Ossendorp
  • S. van der Burg
  • R. Toes
  • R. Offringa
  • C. Melief
Conference paper
Part of the Developments in Hematology and Immunology book series (DIHI, volume 38)

Abstract

In the case of cancer immunity, specific T cells against tumor associated antigens have been shown to be effective. In a bone marrow transplantation setting, adoptive transfer of Epstein Bar virus-specific T cells or infusion of donor lymphocytes, following relapse of chronic myelogenous leukemia, have proven their therapeutic potential. Theoretically, adoptive transfer therapy with highly purified and large quantities of specific CD8+ cytotoxic T lymphocytes (CTL) is desirable for many cancer patients, either in the allogeneic or autologous setting. Disadvantages of this approach include: 1) The high degree of difficulty to clone and expand the required numbers of specific CTL; 2) The patient-specific nature of this approach (MHC restriction); 3) The emergence of new escape variants that have lost the specific target antigens for these CTL; 4) The sophisticated and labor intensive infrastructure required, making this therapy extremely costly.

Keywords

Mature Dendritic Cell Specific Target Antigen Bone Marrow Transplantation Setting Adoptive Transfer Therapy Mock Immunize Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • F. Ossendorp
  • S. van der Burg
  • R. Toes
  • R. Offringa
  • C. Melief
    • 1
  1. 1.Dept of Immunohematology and Blood TransfusionLeiden University Medical CenterLeidenThe Netherlands

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