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Cellular Engineering and Cellular Therapies pp 69–80Cite as

Cell Harvest and Purification Technology — State of the Art and Future Development

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Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 38))

Abstract

Different WBC populations in human blood can be collected for cancer therapy. Hematopoietic stem/progenitor cells (HSPC), originally harvested from bone marrow, are now increasingly collected from blood for autologous and allogeneic transplantations. Umbilical cord blood, discarded until recently, has become a source of HSPC [1–4]. Recently, HSPC have been shown to have the potential to develop into cells of other organ systems [5–21]. In the laboratory, it is possible to grow cells of neural, hepatic cells, and cardiac origins from the bone marrow [20,21]. Clinical protocols are being developed to test the hypothesis of the plasticity of the HSPC.

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  1. Dendreon Corporation, Cell Process Development, Seattle, WA, USA

    P. Law

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  1. Sanquin Consulting Services, Groningen, The Netherlands

    C. Th. Smit Sibinga

  2. Groningen University Institute for Drug Exploration, Groningen, The Netherlands

    L. F. M. H. De Leij

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Law, P. (2003). Cell Harvest and Purification Technology — State of the Art and Future Development. In: Sibinga, C.T.S., De Leij, L.F.M.H. (eds) Cellular Engineering and Cellular Therapies. Developments in Hematology and Immunology, vol 38. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3718-9_7

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