State of the Art in Dendritic Cell Vaccination
Dendritic cells (DC) constitute a family of antigen-presenting cells defined by their morphology and their unique capacity to initiate a primary immune response . It has been shown that DC pulsed with MHC class I peptides are potent inducers of a cytotoxic T lymphocyte (CTL) response in vitro . Furthermore, the presence of DC in tumor tissue has been correlated with a favorable clinical prognosis. Therefore DC are thought to play a pivotal role in the induction of T cell-mediated anti-tumor responses in vivo [3–5]. We, and several other laboratories in the world have initiated clinical studies in which DC vaccines are used to treat cancer.
KeywordsDendritic Cell Melanoma Patient Delay Type Hypersensitivity Keyhole Limpet Hemocyanin Immature Dendritic Cell
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- 16.De Vries, IJM, Krooshoop, DJEB, Scharenborg, NM, et al. Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res 2003 (in press).Google Scholar