Cellular Engineering and Cellular Therapies — An Overview

  • L. F. M. H. de Leij
  • M. J. A. van Luyn
  • M. C. Harmsen
Conference paper
Part of the Developments in Hematology and Immunology book series (DIHI, volume 38)


Cellular therapy offers a challenging approach for the treatment of a variety of diseases. Although some types of cellular therapy, like the generation and application of appropriately differentiated embryonic or adult stem cells, still await the successful outcome of a lot of further experiments, others have been established and clinically applied already a long time ago. So, a lot of clinical experience has been obtained with both autologous and allogeneic bone marrow transplantation protocols and various kinds of immunotherapeutical approaches employing ex vivo activated and cultured NK cells, cytotoxic T lymphocytes or dendritic cells. These trials have shown that cellular therapy can be given in a safe and controlled way. The current Good Manufacturing Practice (cGMP) procedures already established for the preparation, culturing and ex vivo manipulation of cells in these types of applications should be taken into account in implementing appropriate policies and procedures leading to cGMP procedures for future types of cellular therapy such as the use of manipulated stem cells.


Stem Cell Embryonic Stem Cell Adult Stem Cell Cellular Therapy Bone Marrow Derive Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • L. F. M. H. de Leij
  • M. J. A. van Luyn
  • M. C. Harmsen
    • 1
  1. 1.Department of Pathology and Laboratory Medicine, Medical Biology sectionUniversity Medical Centre GroningenGroningenThe Netherlands

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