Summary of Changes
T1 has changed from “Tumor confined within the cortex” to “Tumor 8 cm or less in greatest dimension.”
T2 has changed from “Tumor invades beyond the cortex” to “Tumor more than 8 cm in greatest dimension.”
T3 designation of skip metastasis is defined as “Discontinuous tumors in the primary bone site.” This designation is a Stage III tumor that was not previously defined.
M1 lesions have been divided into M1a and M1b.
M1a is lung-only metastases.
M1b is metastases to other distant sites, including lymph nodes.
In the Stage Grouping, Stage IVA is M1a, and Stage IVB is Mlb
Preview
Unable to display preview. Download preview PDF.
Bibliography
Bacci G, Ferrari S, Bertoni F, et al: Prognostic factors in non-metastatic Ewing’s sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. J Clin Oncol 18:4–11, 2000
Baldini M, Scotlani K, Barbanti-Brodano G, et al: Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. N Engl J Med 333:1380–1385, 1995
Bieling P, Rehan N, Winkler P, et al: Tumor size and prognosis in aggressively treated osteosarcoma. J Clin Oncol 14(3): 848–858, 1996
Cotterill SJ, Ahrens S, Paulussen M, et al: Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol 18:3108–3114, 2000
Davis A, Bell R, Goodwin P: Prognostic factors in osteosarcoma: a critical review. J Clin Oncol 12(2):423–431, 1994
de Alva E, Antonescu CR, Panizo A, et al: Prognostic impact of P53 status in Ewing sarcoma. Cancer; 89:783–792, 2000
de Alva E, Kawai A, Healey JH, et al: EWS-FL11 fusion transcript structure is an independent determinant of prognosis in Ewing’s sarcoma. J Clin Oncol 16:1248–1255, 1998
Enneking WF, Spanier S, Goodman M: A system for the surgical staging of musculoskeletal sarcoma. Clin Orth and Rel Research No. 153, 106–120, 1980
Evans R, Nesbit M, Askin F, et al: Local recurrence, rate and sites of metastases, and time to relapse as a function of treatment regimen, size of primary and surgical history in 62 patients presenting with nonmetastatic Ewing’s sarcoma of the pelvic bones. Int J Radiat Oncol Biol Phys 11:129–136, 1985
Glasser DB, Lane JM, Huvos AG, et al: Survival, prognosis and therapeutic response in osteosarcoma: the Memorial Hospital experience. Cancer 67:698–708, 1992
Gorlick R, Hubos AG, Heller G, et al: Expression of HER2/erbB-2 correlates with survival in osteosarcoma. J Clin Oncol 17:2781–2788, 1999
Hornicek FJ, Gebhardt MC, Wolfe M, et al: P-glycoprotein levels predict poor outcome in patients with osteosarcoma. Clin Orthop and Rel Research 373:11–17, 2000
Mankin HJ, Mankin CJ, Simon MA: The hazards of biopsy, revisited. J Bone and Joint Surg 78A:659–663, 1996
Peabody TD, Gibbs CP, Simon MA: Evaluation and staging of musculoskeletal neoplasms. J Bone and Joint Surg 80A: 1204–1218, 1998
Scully SP, Temple HT, Okeefe RJ, et al: Role of surgical resection in pelvic Ewing’s sarcoma. J Clin Oncol 13(9):2336–2341, 1995
Simon MA, Bierman JS: Biopsy of bone and soft-tissue lesions. J Bone and Joint Surg 75A:616–621, 1993
Sundaram M, McDonald DJ: Magnetic resonance imaging in the evaluation of the solitary tumor of bone. Current Opinion in Radiology 2:697–702, 1990
Sundaram M, McDonald DJ: The solitary tumor or tumor-like lesion of bone. Top Magn Reson Imag 1(4): 17–29, 1989
Sundaram M, McGuire MH: Computed tomography or magnetic resonance for evaluating the solitary tumor or tumorlike lesion of bone? Skeletal Radiology 17:393–401, 1988
Ward WG, Mikaelian K, Dorey F, et al: Pulmonary metastases of stage IIB extremity osteosarcoma and subsequent pulmonary metastases. J Clin Oncol 12(9):1849–1858, 1994
Wei G, Antonescu CR, de Alva E, et al: Prognostic impact of INK4A deletion in Ewing sarcoma. Cancer 89:793–799, 2000
Wuisman P, Enneking WF: Prognosis for patients who have osteosarcoma with skip metastasis. J Bone and Joint Surg 72A(l):60–68, 1990
Wunder JS, Bull SB, Aneliunas V, et al: MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol 18:2685–2694, 2000
Author information
Authors and Affiliations
Consortia
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
American Joint Committee on Cancer. (2002). Bone. In: Greene, F.L., et al. AJCC Cancer Staging Manual. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3656-4_21
Download citation
DOI: https://doi.org/10.1007/978-1-4757-3656-4_21
Publisher Name: Springer, New York, NY
Print ISBN: 978-3-540-00595-7
Online ISBN: 978-1-4757-3656-4
eBook Packages: Springer Book Archive