Ampulla of Vater

Carcinoid tumors and other neuroendocrine tumors are not included
  • American Joint Committee on Cancer

Summary of Changes

There is no longer a distinction between T3 and T4 on the basis of the depth of pancreatic invasion.

The stage grouping has been revised.

Stage I has been replaced with Stage IA and Stage IB.

Stage II has been replaced with Stage IIA and Stage IIB.

Node positive disease has been moved to Stage IIB to retain consistency with the staging of tumors of the bile duct and of the pancreas.


Common Bile Duct Adenomatous Polyposis Coli Papillary Carcinoma Small Cell Carcinoma Mucinous Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allema JH, Reinders ME, van Gulik TM, et al: Prognostic factors for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region. Cancer 75:2069–2076, 1995PubMedCrossRefGoogle Scholar
  2. Bakkevold KE, Kambestad B: Long-term survival following radical and palliative treatment of patients with carcinoma of the pancreas and papilla of Vater—the prognostic factors influencing the long-term results: a prospective multicentre study. Eur J Surg Oncol 19:147–161, 1993PubMedGoogle Scholar
  3. Bakkevold KE, Kambestad B: Staging of carcinoma of the pancreas and ampulla of Vater: tumor (T), lymph node (N), and distant metastasis (M) as prognostic factors. Int J Pan-creatol 17:249–259, 1995Google Scholar
  4. Beger HG, Treitschke F, Gansauge F, et al: Tumor of the ampulla of Vater. Arch Surg 134:526–532, 1999PubMedCrossRefGoogle Scholar
  5. Bottger TC, Boddin J, Heintz A, et al: Clinicopathologic study for the assessment of resection for ampullary carcinoma. World J Surg 21:379–383, 1997PubMedCrossRefGoogle Scholar
  6. Compton CC: Protocol for the examination of specimens from patients with carcinoma of the ampulla of Vater. Arch Pathol Lab Med. 121:673–677, 1997PubMedGoogle Scholar
  7. Cubilla AL, Fitzgerald PJ: Tumors of the exocrine pancreas. In Atlas of tumor pathology, 2nd series, fascicle 19, Washington, DC: Armed Forces Institute of Pathology, 1984Google Scholar
  8. Delcore R Jr, Connor CS, Thomas JH, et al: Significance of tumor spread in adenocarcinoma of the ampulla of Vater. Am J Surg 158:593–596, 1989PubMedCrossRefGoogle Scholar
  9. Dorandeau A, Raoul J-L, Sisiser F, Leclercq-Rioux N, et al: Carcinoma of the ampulla of Vater: prognostic factors after curative surgery: a series of 45 cases. Gut 40:350–355, 1997Google Scholar
  10. Griffanti-Bartoli F, Arnone GB, Ceppa P, et al: Malignant tumors in the head of the pancreas and the periampullary region: diagnostic and prognostic aspects. Anticancer Res 14:657–666, 1994PubMedGoogle Scholar
  11. Harada N, Treitschke F, Imaizumi T, Beger HG. Pancreatic invasion is a prognostic indicator after radical resection for carcinoma of the ampulla of Vater. J Hep Bil Pancr Surg 4:215–219, 1997CrossRefGoogle Scholar
  12. Howe JR, Klimstra DS, Moccia RD, et al: Factors predictive of survival in ampullary carcinoma. Ann Surg 228:87–94, 1998PubMedCrossRefGoogle Scholar
  13. Kayahara M, Nagakawa T, Ohta T, Kitagawa H, Miyazaki I. Surgical strategy for carcinoma of the papilla of Vater on the basis of lymphatic spread and mode of recurrence. Surgery 121:611–617, 1997PubMedCrossRefGoogle Scholar
  14. Klempnauer J, Ridder GH, Bektas H, et al: Surgery for exocrine pancreatic cancer—who are the 5- and 10-year survivors? Oncology 52:353–359, 1995PubMedCrossRefGoogle Scholar
  15. Knox RA, Kingston RD: Carcinoma of the ampulla of Vater. Br J Surg 73:72–73, 1976CrossRefGoogle Scholar
  16. Lee JH, Whittington R, Williams NN, et al: Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas. Int J Radiat Oncol Biol Phys 47:945–953, 2000PubMedCrossRefGoogle Scholar
  17. Makipour H, Cooperman A, Danzi JT, et al: Carcinoma of the ampulla of Vater. Ann Surg 183:341–344, 1976PubMedCrossRefGoogle Scholar
  18. Martin MF, Rossi RL, Dorucci V, et al: Clinical and pathologic correlations in patients with periampullary tumors. Arch Surg 125:723–726, 1990PubMedCrossRefGoogle Scholar
  19. Monson JRT, Donohue JH, McEntee GP, et al: Radical resection for carcinoma of the ampulla of Vater. Arch Surg 126:353 – 357, 1991Google Scholar
  20. Mori K, Ikei S, Yamane T, et al: Pathological factors influencing survival of carcinoma of the ampulla of Vater. Eur J Surg Oncol 16:183–188, 1990PubMedGoogle Scholar
  21. Nelptolemos JP, Talbot IC, Shaw DC, et al: Long-term survival after resection of ampullary carcinoma is associated independently with tumor grade and a new staging classification that assesses local invasiveness. Cancer 61:1403–1407, 1988CrossRefGoogle Scholar
  22. Roberts RH, Krige JE, Bornman PC, Terblanche J. Pancreaticoduodenectomy of ampullary carcinoma. Am Surg 65:1043–1048, 1999PubMedGoogle Scholar
  23. Shirai Y, Tsukada K, Ohtani T, et al: Carcinoma of the ampulla of Vater: histopathologic analysis of tumor spread in Whipple pancreatoduodenectomy specimens. World J Surg 19:102–107, 1995PubMedCrossRefGoogle Scholar
  24. Talamini MA, Moesinger RC, Pitt HA, et al: Adenocarcinoma of the ampulla of Vater: a 28-year experience. Ann Surg 225:590–600, 1997PubMedCrossRefGoogle Scholar
  25. Willett CG, Warshaw AL, Convery K, et al: Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma. Surg Gynecol Obstet 176:33–38, 1993PubMedGoogle Scholar
  26. Wise L, Pizzimbono C, Dehner IP: Periampullary cancer. Am J Surg 131:141–148, 1976PubMedCrossRefGoogle Scholar
  27. Yamaguchi K, Enjoji M: Carcinoma of the ampulla of Vater: a clinicopathologic study and pathologic staging of 109 cases of carcinoma and 5 cases of adenoma. Cancer 59:506–515, 1987PubMedCrossRefGoogle Scholar
  28. Yasuda K, Mukai H, Cho E, et al: The use of endoscopic ultrasonography in the diagnosis and staging of carcinoma of the papilla of Vater. Endoscopy 20(Suppl):218–222, 1988PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • American Joint Committee on Cancer
    • 1
  1. 1.Executive OfficeChicagoUSA

Personalised recommendations