Summary of Prefrontal Molecular Abnormalities in the Stanley Foundation Neuropathology Consortium

  • Michael B. Knable
  • Beata M. Barci
  • Maree J. Webster
  • E. Fuller Torrey
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)


Postmortem specimens from the Stanley Foundation Neuropathology Consortium, which contains matched samples from patients with schizophrenia, bipolar disorder, non-psychotic depression, and normal controls (n=15 per group), have been distributed to many research groups around the world. This chapter provides a summary of abnormal markers found in prefrontal cortical areas from this collection between 1997 and 2000. From 69 separate data sets, a total of 17 abnormal markers were identified that pertained to a variety of neural systems and processes including neuronal plasticity, neurotransmission, signal transduction, inhibitory interneuron function, and glial cells. Schizophrenia was associated with the largest number of abnormalities, many of which were also present in bipolar disorder. Major depression was associated with relatively few abnormalities. Most abnormal findings represented a decrease in protein or mRNA levels that could not be fully explained by exposure to psychotropic or illicit drugs or by other confounding variables. It is argued that the abnormal findings are not due to stochastic processes but represent viable markers for independent replication and further study as candidate genes or targets for new treatments.


Bipolar Disorder Prefrontal Cortex Glial Fibrillary Acidic Protein Diagnostic Group Linear Discriminant Function 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Michael B. Knable
  • Beata M. Barci
  • Maree J. Webster
  • E. Fuller Torrey

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