Studies in the Human Frontal Cortex: Evidence for Changes in Neurochemical Markers in Schizophrenia and Bipolar Disorder

  • Brian Dean
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)


Commonality of treatments in schizophrenia and bipolar disorder suggest that there may be a single pathology driving some of the symptoms of these illnesses. To test this hypothesis, the literature on the changes in the molecular neuroanatomy of postmortem brain tissue from subjects with schizophrenia and bipolar disorder has been reviewed to attempt to identify a common neurobiology. Such studies provide evidence to suggest that changes in the serotonergic system of the frontal cortex may be such a common factor. However, currently available data does not support the argument that the same changes in the serotonergic systems of the frontal cortex are present in schizophrenia and bipolar disorder. By contrast, such data would suggest that targeting receptor-G-protein interactions might be therapeutically beneficial in both illnesses.


Bipolar Disorder Frontal Cortex Serotonin Receptor Serotonin Transporter Serotonergic System 
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© Springer Science+Business Media New York 2002

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  • Brian Dean

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