Indications of Abnormal Connectivity in Neuropsychiatric Disorders in Postmortem Studies

  • William G. Honer
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)

Abstract

Proteins enriched in presynaptic terminals are frequently used as postmortem markers for neural connectivity in neuropsychiatric disorders. This chapter describes the animal studies which form the foundation for interpreting results in humans, followed by comments on studies in dementia and other disorders. Studies of presynaptic proteins and their mRNAs in schizophrenia and affective disorders indicate that multiple proteins are abnormally expressed or regulated. In the future, an approach which considers interactions between presynaptic proteins involved in neurotransmission may be fruitful.

Keywords

Synaptic Protein Synaptic Vesicle Protein Presynaptic Protein Bioi Psychiatry Mossy Fibre Terminal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2002

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  • William G. Honer

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