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Indications of Abnormal Connectivity in Neuropsychiatric Disorders in Postmortem Studies

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The Postmortem Brain in Psychiatric Research

Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 4))

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Abstract

Proteins enriched in presynaptic terminals are frequently used as postmortem markers for neural connectivity in neuropsychiatric disorders. This chapter describes the animal studies which form the foundation for interpreting results in humans, followed by comments on studies in dementia and other disorders. Studies of presynaptic proteins and their mRNAs in schizophrenia and affective disorders indicate that multiple proteins are abnormally expressed or regulated. In the future, an approach which considers interactions between presynaptic proteins involved in neurotransmission may be fruitful.

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Authors
  1. William G. Honer
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Editors and Affiliations

  1. Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

    Galila Agam  & R. H. Belmaker  & 

  2. Departments of Neuropathology and Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, SE5 8AF, London, UK

    Ian Paul Everall

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Honer, W.G. (2002). Indications of Abnormal Connectivity in Neuropsychiatric Disorders in Postmortem Studies. In: Agam, G., Everall, I.P., Belmaker, R.H. (eds) The Postmortem Brain in Psychiatric Research. Neurobiological Foundation of Aberrant Behaviors, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3631-1_6

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  • DOI: https://doi.org/10.1007/978-1-4757-3631-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-4921-9

  • Online ISBN: 978-1-4757-3631-1

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