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The Postmortem Brain in Psychiatric Research pp 37–48Cite as

Imaging VS Postmortem Receptor Studies: What You See is What You Get?

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Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 4))

Abstract

Postmortem research historically provided the technical and evidential basis for in vivo receptor imaging. In vitro mapping of receptor distribution and density is an essential first step for novel tracer development in order to image brain receptors in a living human subject. The chapter reviews the technical distinctions between receptor estimation postmortem and in vivo. The advantages and disadvantages of each approach are also discussed with respect to psychiatric disorder in particular. The neuropharmacology of schizophrenia has been most studied with neuroreceptor imaging and is used as an instructive example of the contribution of both methodologies to understanding the role of dopamine in the disorder. These data include simple studies estimating dopamine D2 receptors in schizophrenia, dynamic in vivo challenges of the dopamine system, and examining the links between dopamine D2 receptor occupancy by antipsychotic drugs and their toxic and therapeutic effects. These studies reveal the necessity of bridging the gap between ante- and postmortem research in schizophrenia and other disorders.

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Authors
  1. Lyn Pilowsky
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Editors and Affiliations

  1. Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

    Galila Agam  & R. H. Belmaker  & 

  2. Departments of Neuropathology and Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, SE5 8AF, London, UK

    Ian Paul Everall

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© 2002 Springer Science+Business Media New York

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Pilowsky, L. (2002). Imaging VS Postmortem Receptor Studies: What You See is What You Get?. In: Agam, G., Everall, I.P., Belmaker, R.H. (eds) The Postmortem Brain in Psychiatric Research. Neurobiological Foundation of Aberrant Behaviors, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3631-1_4

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  • DOI: https://doi.org/10.1007/978-1-4757-3631-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-4921-9

  • Online ISBN: 978-1-4757-3631-1

  • eBook Packages: Springer Book Archive

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