Methodological and Stereological Considerations in Postmortem Psychiatric Brain Research

  • Ian Paul Everall
  • Paul J. Harrison
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)

Abstract

There has been a renewal of interest in understanding the brain changes that may underlie schizophrenia. However, microscopic assessment of the brain is not a trivial task and there are many potential factors, which can affect experimental results. In this chapter we will review the major potential confounding variables to be considered and principles of quantifying microscopic indices such as cell number and size. In this regard the basic principles of stereology will be outlined as well as the basic ideas of quantifying cellular arrangement by the newly emerging tool of spatial pattern analysis. During these description examples from the published literature will be provided.

Keywords

Major Depressive Disorder Superior Temporal Gyrus Postmortem Interval Complete Spatial Randomness Metachromatic Leukodystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ian Paul Everall
  • Paul J. Harrison

There are no affiliations available

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