Psychiatric Brain Banks: Situation in Europe and Asia

  • I. Matsumoto
  • S. I. Niwa
  • R. Ravid
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)


Brain banking systems and networks in various parts of the world. exhibit a large variety; they differ in many aspects which affect and influence the main fields of scientific research, as the flow of dessiminated material strongly depends on the legal, ethical, cultural and religious background and reflects the local situation in each country. The daily practice and routine procedures of brain banks in three continents (Europe, Asia and America) represent basic differences in the nations involved, scientific communities and the interactions between these two. European brain banks differ from the American and Asian groups collecting postmortem material for research. The various networks collaborate on the standardisation of protocols and diagnostic criteria and try to establish solid concensus criteria. Brain banking is not well advanced in Asian countries. There are several lines of reasons for this. Firstly, the biological approach to psychiatric disorders are not well accepted among psychiatrists compared with western countries. Secondly, spontaneous participation of users and families to understand and to support biological researches are not encouraged enough. However, as initiated by Japan, there is certainly a movement to form a nation-wide brain bank network with internationalized criteria in various Asian countries.


Central European Bank Donor Program Fukushima Prefecture Brain Bank Postmortem Human Brain Tissue 
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  1. Anderson R, Balls M, Burke MD, Cummins M, Fehily D, Gray N, de MG, Helin H, Hunt C, Jones D, Price D, Richert L, Ravid R, Shute D, Sladowski D, Stone H, Thasler W, Trafford J, van der Valk J, Weiss T, Womack C, Ylikomi T. The establishment of human research tissue banking in the UK and several western european countries: the report and recommendations of ecvam workshop 44. Altern Lab Anim 2001; 29: 125–134.PubMedGoogle Scholar
  2. Andreasen NC, Arndt S, Swayze V II, Cizadlo T, Falum M, O’Leary D, Ehrhardt JC, Yuh, WTC. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 1994; 266: 294–298.PubMedCrossRefGoogle Scholar
  3. Bell J, Ironside J. Principles and practice of “high risk” brain banking. Neuropathol Appl Neurobiol 1997; 23: 281–288PubMedCrossRefGoogle Scholar
  4. Bidaut-Russell M, Ravid R, Cruz-Sanchez FF, Grossberg GT, McKeel DW. Survey of North American and European dementia brain banks: a 1994 directory. Alzheimer’s disease and Related Disorders 1995; 9: 193–202.Google Scholar
  5. Bogerts B. Recent advances in the neuropathology of schizophrenia. Schizophr Bull 1993; 19: 43–45.CrossRefGoogle Scholar
  6. Bogerts B. The neuropathology of schizophrenic disease: historical aspects and present knowledge. Eur Arch Psychiatry Clin Neurosci 1999; 249 SupIl 4: 2–13.Google Scholar
  7. Budka, H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gillotta F, Haltia M, Hauw JJ, Ironside JW, Kretzschmar HA, Lantos PL, Masullo C, Pocchiari M, Schlote W, Tateishi J, Will RG. Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (Prion diseases). Brain Pathol 1995; 5: 319–322.PubMedCrossRefGoogle Scholar
  8. Cruz-Sanchez FF and E. Tolosa — The need for a consensus for brain banking. How to run a brain bank. J Neural Transm 1993;39Suppl: 1–4.Google Scholar
  9. Cruz-Sanchez FF, Ravid R, Cuzner ML. The European Brain Bank Network (EBBN) and the need of standardized neuropathological criteria for brain tissue cataloguing. In: Neuropathological Diagnostic Criteria for Brain Banking, European Union Biomedical and Health Research, Vol. 10, F.F. Cruz-Sanchez, M.L. Cuzner and R. Ravid (Eds), IOS Press, 1995, Amsterdam, The Netherlands, pp. 1–3.Google Scholar
  10. Cruz-Sànchez FF, Mordini E, Ravid R. Ethical aspects to be considered in brain banking. Ann Ist Super Sanità 1997; 33: 477–482.PubMedGoogle Scholar
  11. Duyckaerts, C, Delaère P, Hauw JJ, Abbamondi-Pinto AL, Sorbi S, Allen I, Brion JP, Flament-Durand J, Duchen L, Kauss J, Schlote W, Lowe J, Probst A, Ravid R, Swaab DF, Renkawek K, Tomlinson B. Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE. J Neurol Sci 1990; 97: 295–323.PubMedCrossRefGoogle Scholar
  12. Hardy JA, Wester P, Winblad B, Gezelius C, Bring G, Eriksson A. The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue. J Neural Transm 1985; 61: 253–264.PubMedCrossRefGoogle Scholar
  13. Hauw, JJ, Sazdovitch V, Maokhtari K, Seilhaen D, Camilleri S, Kondo H, Duyckaerts C. Techniques de prevention des agents trasmissibles non conventionnels au laboratoire. L’exemple de l’anatomie pathologique. In: J. Grosset, M. Kitzis, N Lambert, M Sinegre eds: Prevention des infections nosocomiales. Protection contre les germes 19Google Scholar
  14. multiresistants,.Amette Blackwell, Paris 1995; pp 171 — 177.Google Scholar
  15. Johnston NL, Cervenak J, Shore AD, Torrey EF, Yolken RH, Cerevnak J. The StanelyNeuropathology Consortium. Multivariate analysis of RNA levels from postmortem human brains as measured by three different methods of RT-PCR. J Neurosci Meth. 1997; 77: 83–92.CrossRefGoogle Scholar
  16. Kahn J, Bittner ML, Chen Y, Meltzer PS, Trent JM. DNA microarray technology; theanticipated impact on the study of human disease. Biochem Biophys Acta 1999; 1423 (2): M17–M28.Google Scholar
  17. Kingsbury AE, Foster OJ, Nisbet AP, Cairns NJ, Bray L, Eve DJ. Tissue pH as indicator of mRNA preservation in human postmortem brain. Brain Res Mol Brain Res 1995; 28: 311–318.PubMedCrossRefGoogle Scholar
  18. Kromkamp M, Ravid R, Swaab DF. Protocol for the initiation of a postmortem research programme in schizophrenia in the Netherlands, Netherlands Brain Bank, Annual Report 1998–2000.Google Scholar
  19. Pakkenberg, B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schzophrenics. Arch Gen Psychiatry 1990; 47: 1023–1028.PubMedCrossRefGoogle Scholar
  20. Perry EK, Perry RH, Tomlinson BE. The influence of agonal state on some neurochemical activities of postmortem human brain tissue. Neurosi Lett 1982; 29: 303–309.CrossRefGoogle Scholar
  21. Ravid R, van Zwieten EJ, Swaab DF. Brain Banking and the human hypothalammus —factors to match for, pitfalls and potentials.In: DF Swaab, M.A. Hofman, M. Mirmiran, et al. (eds) The human hypothalamus in health and disease. Elsevier, Amsterdam, 1992; pp 83–95.Google Scholar
  22. Ravid, R, Winblad B. In: Alzheimer’s Disease: Advances in Clinical and BasicResearch, B.Corain, K. Iqbal, M. Nicolini, B. Winblad, H. Wisniewski and P. Zatta (eds.) 1993, John Wiley & Sons, Sussex, U.K., pp. 213–218.Google Scholar
  23. Ravid R, Swaab, DF. The Netherlands Brain Bank; a clinico-pathological link in aging andGoogle Scholar
  24. dementia research. J. Neural Transm. 1993, Suppl. 39: 143–153, Springer-Verlag, Vienna, Ravid R, Swaab DF. Brain Banking in Alzheimer’s disease: pitfalls and potentials. J NeuropathGoogle Scholar
  25. Appl Neurobiol 1995a; 21, Suppl 1: 18–19.Google Scholar
  26. Ravid R, Swaab DF, Kamphorst W, Van Zwieten EJ. A golden standard protocol for the brain banking society? The Amsterdam Experience. J Neuropathol Exp Neurol 1995b;54, Suppl: 25–26S.Google Scholar
  27. Ravid, R., Swaab DF, Van Zwieten EJ, Salehi A. Controls are what makes a brain bank go round. In: Neuropathological Diagnostic Criteria for Brain Banking. Cruz-Sanchez FF, Ravid R, Cuzner ML (eds), IOS Press, Amsterdam, 1995c; pp 4–13.Google Scholar
  28. Riederer P, Gsell W, Calza L, Franzek E, Junkunz G, Dellinger K, Reynods, GP, Crow T, Cruz-Sanchez FF, Beckmann H. Consensus on minimal criteria of clinical and neuropathological diagnosis of schizophrenia and affective disorders for postmortem research. J Neural Transm 1995; 102: 255–264.CrossRefGoogle Scholar
  29. Schramm M, Falkai P, Tepest R, Schneider-Axmann T, Przkora R, Waha A, Pietsch T, Bonte W, Bayer TA. Stability of RNA transcripts in postmortem psychiatric brains, J Neural Transm 1999; 106: 329–335.PubMedCrossRefGoogle Scholar
  30. Swaab, DF, Uylings HBM. Potentialities and pitfalls in the use of human brain material in molecular neuroanatomy. In: Molecular Neuroanatomy, F.W. van Leeuwen, R.M. Buys, C.W. Pool and O. Pach (Eds.), Elsevier Science Publishers, Amsterdam, 1988; pp 403–416.Google Scholar
  31. Swaab, DF, Hauw JJ, Reynolds GP, Sorbi S. Tissue Banking and EURAGE. J Neurol Sci 1989; 93: 341–343.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • I. Matsumoto
  • S. I. Niwa
  • R. Ravid

There are no affiliations available

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