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cAMP Signal Transduction Abnormalities in the Pathophysiology of Mood Disorders: Contributions from Postmortem Brain Studies

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Book cover The Postmortem Brain in Psychiatric Research

Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 4))

Abstract

During the past decade, considerable advances have been made in second messenger and signal transduction research in mood disorders. In this chapter, evidence derived from human postmortem brain studies is reviewed which supports the emerging view that postreceptor disturbances in G protein-linked cAMP signaling pathways play a major role in the pathophysiology of bipolar (BD) and major depressive disorders (MDD). In addition, the pathophysiological implications of the available evidence are also discussed, within the context of findings from recent neuroimaging and neuropathological studies.

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Authors
  1. Annisa Chang
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  2. Peter P. Li
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  3. Jerry J. Warsh
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Editors and Affiliations

  1. Stanley Foundation International Research Center and Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel

    Galila Agam  & R. H. Belmaker  & 

  2. Departments of Neuropathology and Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, SE5 8AF, London, UK

    Ian Paul Everall

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Chang, A., Li, P.P., Warsh, J.J. (2002). cAMP Signal Transduction Abnormalities in the Pathophysiology of Mood Disorders: Contributions from Postmortem Brain Studies. In: Agam, G., Everall, I.P., Belmaker, R.H. (eds) The Postmortem Brain in Psychiatric Research. Neurobiological Foundation of Aberrant Behaviors, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3631-1_19

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