GSK-3 and Wnt Markers of Neurodevelopmental Abnormalities in Schizophrenia

  • Nitsan Kozlovsky
  • Rh Belmaker
  • Galila Agam
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)


The Neurodevelopmental Hypothesis of schizophrenia suggests that interaction between genetic and environmental events occurring during critical early periods in neuronal growth may negatively influence the way by which nerve cells are laid down, differentiated and selectively culled by apoptosis. Recent advances offer insights into the regulation of brain development. The Wnt family of genes plays a central role in normal brain development. Activation of the Wnt cascade leads to inactivation of glycogen synthase kinase-3ß (GSK-3ß), accumulation and activation of ßcatenin and expression of genes involved in neuronal development. The possible role of aberrant GSK-3 in the etiology of schizophrenia is discussed.


Schizophrenic Patient Neural Cell Adhesion Molecule Radiation Hybrid Mapping Neuronal Cell Adhesion Molecule Neurodevelopmental Hypothesis 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Nitsan Kozlovsky
  • Rh Belmaker
  • Galila Agam

There are no affiliations available

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