Post Mortem Studies of the Hippocampal Formation in Schizophrenia
In recent years, dramatic abnormalities have been found in the hippocampal formation in schizophrenia. These include diminished levels of dendritic spines, reelin, and the 67 kd isoform of glutamic acid decarboxylase, and increased levels of brain derived neurotrophic factor. These findings are not limited to the hippocampal formation and are consistent with excessive synaptic pruning. So far, however, there is little to indicate when the process began.
KeywordsDendritic Spine Entorhinal Cortex Hippocampal Formation Presynaptic Protein Bioi Psychiatry
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