Microanatomical Findings in Postmortem Brain Tissue from Subjects with Schizophrenia: Disturbances in Thalamocortical and Corticocortical Connectivity in Schizophrenia

  • T. Hashimoto
  • D. A. Lewis
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)


Evidence from clinical studies suggest that the prefrontal cortex and hippocampal formation are sites of dysfunction in schizophrenia. Postmortem investigations have revealed several types of cellular alterations that appear to be common to both of these brain regions. These changes include reductions in cortical volume or thickness, increased neuronal density without a change in total neuronal number, reduced somal size and alterations in the dendritic trees of projection neurons, and decreased markers of presynaptic axon terminals. This chapter reviews the data that support these conclusions and considers these findings in the context of the extent to which they reflect alterations in thalamocortical and corticocortical connectivity in schizophrenia.


Pyramidal Neuron Entorhinal Cortex Hippocampal Formation Parahippocampal Gyrus Neuronal Density 
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© Springer Science+Business Media New York 2002

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  • T. Hashimoto
  • D. A. Lewis

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