Latent Class Models to Describe Changes Over Time: A Case Study

  • Hans C. van Houwelingen


By means of a case study we describe the statistical analysis of repeated measures as they may be found in a typical quality-of-life trial that studies the effect of some intervention on quality-of-life. We will show that latent class models are a very useful to tool to discover patterns in the follow-up data. Once the patterns have been found, data-driven summary statistics can be defined that are more useful than simple pre-defined measures of response.


Pain Score Principal Curve Multivariate Normal Distribution Latent Class Model Intermediate Response 
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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Hans C. van Houwelingen
    • 1
  1. 1.Leiden University Medical CenterNetherlands

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