Skip to main content

Latent Class Models to Describe Changes Over Time: A Case Study

  • Chapter
Statistical Methods for Quality of Life Studies
  • 536 Accesses

Abstract

By means of a case study we describe the statistical analysis of repeated measures as they may be found in a typical quality-of-life trial that studies the effect of some intervention on quality-of-life. We will show that latent class models are a very useful to tool to discover patterns in the follow-up data. Once the patterns have been found, data-driven summary statistics can be defined that are more useful than simple pre-defined measures of response.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Beacon, H.J., Thompson, S.G and England, P.D. (1998). The analysis of complex patterns of longitudinal binary response: an example of transient dysphagia following radiotherapy. Statistics in Medicine 17, 2551–2561.

    Article  PubMed  CAS  Google Scholar 

  • Berkey, C.S., Laird, N.M., Valadian, I. and Gardner J. (1991). Modelling adolescent blood pressure patterns and their prediction of adult pressures. Biometrics 47, 1005–1018.

    Article  PubMed  CAS  Google Scholar 

  • Laird, N.M., Lange, N. and Stram, D. (1987). Maximum Likelihood computations with repeated measures: application of the EM algorithm. Journal of the American Statistical Association 82, 97–105.

    Article  Google Scholar 

  • Laird, N.M. and Ware, J.H. (1982). Random-effects models for longitudinal data. Biometrics 38, 963–974.

    Article  PubMed  CAS  Google Scholar 

  • Little, R.J.A. and Rubin, D.B. (1987). Statistical Analysis with Missing Data, New York: Wiley.

    Google Scholar 

  • McLachlan, G.F. and Krishnan, H. (1997). The EM Algorithm and Extensions, New York:Wiley.

    Google Scholar 

  • Meng, X.-L. and Van Dyk, D. (1997). The EM algorithm-an old folk-song sung to a fast new tune. Journal of the Royal Statistical Society Series B 58, 511–567.

    Google Scholar 

  • Skene, A.M. and White, S.A. (1992). A latent class model for repeated measurement experiments. Statistics in Medicine 11, 2111–2122.

    Article  PubMed  CAS  Google Scholar 

  • Steenland, E., Leer, J., van Houwelingen, H., Post, W.J., van den Hout, W.B., Kievit, J., de Haes, H., Martijn, H., Oei, B., Vonk, E., van der Steen-Banasik, E., Wiggenraad, R.G.J., Hoogenhout, J., Warlam-Rodenhuis, C., van Tienhoven, G., Wanders, R., Pomp, J., van Reijn, M., Mierlo, T. and Rutten, E. (1999). The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiotherapy and Oncology 52, 101–109.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

van Houwelingen, H.C. (2002). Latent Class Models to Describe Changes Over Time: A Case Study. In: Mesbah, M., Cole, B.F., Lee, ML.T. (eds) Statistical Methods for Quality of Life Studies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3625-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-3625-0_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-5207-3

  • Online ISBN: 978-1-4757-3625-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics