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G Proteins and G Protein-Coupled Receptors

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Book cover Hormone Signaling

Part of the book series: Endocrine Updates ((ENDO,volume 17))

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Abstract

Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of the organism, cells must be able to access this changing information. The biochemical mediators of this information exchange are cell surface receptors. Receptors transduce information from the extracellular space to the intracellular compartment. This process involves the following steps: receptor activation, G protein coupling, and second messenger generation. Equally important in cell signaling is the termination of this signal including desensitization, internalization and resensitization. All these steps represent potential regulatory checkpoints and possible targets for therapeutic intervention. Cell surface receptors include G protein-coupled receptors (GPCRs), as well as, ion channels and enzyme-linked receptors. GPCRs are responsible for physiological responses as diverse as visual perception, neurotransmission, cell growth and cell differentiation.

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  1. Howard Hughes Medical Institute Laboratories and Department of Cell Biology and Medicine, Duke University Medical Center, Durham, NC, 27710, USA

    Michael A. Shetzline & Marc G. Caron

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  1. Michael A. Shetzline
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  2. Marc G. Caron
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  1. Inserm Unit 344, Molecular Endocrinology, Faculty of Medicine Necker, Paris, France

    Vincent Goffin PhD  & Paul A. Kelly PhD  & 

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Shetzline, M.A., Caron, M.G. (2002). G Proteins and G Protein-Coupled Receptors. In: Goffin, V., Kelly, P.A. (eds) Hormone Signaling. Endocrine Updates, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3600-7_9

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