The GnRH Gene

  • Andrea C. Gore
Chapter

Abstract

There are multiple GnRHs in the brains of many organisms (see Chapter 6). The GnRH-1 gene encoding the decapeptide synthesized in the preoptic area and hypothalamus, and responsible for hypophysiotropic function, is the focus of the current chapter. The proGnRH-1 gene has been cloned in a number of species including rats, mice, humans, teleost fish, amphibians, and birds (Adelman et al., 1986; Hayflick et al., 1989; Mason et al., 1986; Seeburg and Adelman, 1984; reviewed in Fernald and White, 1999; Lin et al., 1998; Wierman et al., 1995). The non-hypophysiotropic GnRHs (GnRH-2, found primarily in midbrain, and GnRH-3, in olfactory and terminal nerve regions) derive from different genes than GnRH-1, although the amino acid sequences of these three GnRH molecules are highly homologous.

Keywords

NMDA Receptor Masu Salmon GnRH Neuron GnRH Release GnRH mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Andrea C. Gore
    • 1
  1. 1.Neurobiology of Aging LaboratoriesMount Sinai School of MedicineNew YorkUSA

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