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Dopamine Receptors in Schizophrenia

  • Tetsuya Suhara
  • Fumihiko Yasuno
  • Yoshiro Okubo
  • Yasuhiko Sudo
  • Makoto Inoue
  • Tetsuya Ichimiya
  • Akihiro Takano
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Schizophrenia is believed to involve altered dopaminergic transmission. This is supported by the fact that chronic use of dopamine agonists such as amphetamine can cause psychotic symptoms, and dopamine D2 receptor antagonists are the most widely used drugs for the treatment of schizophrenia. However, most of the in vivo imaging studies with drug-free or drug-naive patients could not detect a significant change in striatal D2 receptors 1. On the other hand, neuropathological 2 and neuroimaging studies have demonstrated abnormalities in the extrastriatal regions of schizophrenia. Dopamine receptors are classified into five subtypes, and selective ligands have been developed for D1 and D2 subtypes. In the cortical regions, the density of D1 receptor is higher than that of D2 receptor3, 4 . Dl receptor has been implicated in the control of working memory. We have recently reported the abnormality of dopamine D1 receptor binding in the prefrontal cortex of patients with schizophrenia, and its relation to negative symptoms and poor performance in the Wisconsin Card Sorting Test5. On the other hand, an increasing body of evidence favors a crucial role of extrastriatal regions in the pathophysiology of positive symptoms, and the extrastriatal D2 receptor is expected to be the common site of action of antipsychotics 6. We found that extrastriatal dopamine D2 receptor was the site of antipsychotic drug action 7. However, unexpectedly, reduced D2 receptor binding was observed in the anterior cingulate cortex of patients with schizophrenia, and a significant negative correlation was observed between D2 receptor binding and the positive symptom score on Brief Psychiatric Rating Scale (BPRS) 8.

Keywords

Anterior Cingulate Cortex Negative Symptom Binding Potential Brief Psychiatric Rating Scale Endogenous Dopamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M. Lamelle, Imaging dopamine transmission in schizophrenia. Q. J. Nucl. Med.42, 211–221 (1998).Google Scholar
  2. 2.
    F. M. Benes, J. McSparren, E. D. Bird, J. P. SanGiovanni, S. L. Vincent, Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch. Gen. Psych. 48, 996–1001(1991)CrossRefGoogle Scholar
  3. 3.
    T. Suhara, H. Fukuda, O. Inoue, T. Itoh, K. Suzuki, T. Yamasaki, Y. Tateno, Age-related changes in human D1 dopamine receptors measured by positron emission tomography. Psychopharmacology, 103, 41–45 (1991).PubMedCrossRefGoogle Scholar
  4. 4.
    T. Suhara, Y Sudo, T. Okauchi, J. Maeda, K. Kawabe, K. Suzuki, Y Okubo, Y Nakashima, H. Ito, S. Tanada, C. Halldin, L. Farde, Extrastriatal dopamine D2 receptor density and affinity in the human brain measured by 3D PET. Int. J. Neuropsychopharmacol. 2, 73–82 (1999).CrossRefGoogle Scholar
  5. 5.
    Y Okubo, T. Suhara, K. Suzuki, K. Kobayashi, O. Inoue, O. Terasaki, Y Someya, T. Sassa, Y Sudo, E. Matsushima, M. Iyo, Y Tateno, M. Toru. Decreased prefrontal dopamine Dl receptors in schizophrenia revealed by PET. Nature 385, 634–636 (1997).PubMedCrossRefGoogle Scholar
  6. 6.
    L. Farde, T. Suhara, S. Nyberg, P. Karlsson, Y Nakashima, Y Hietala, C. A. Halldin, A PET-study of [11C]FLB 457 binding to extrastriatal D2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients. Psychopharmacology 133, 396–404 (1997).PubMedCrossRefGoogle Scholar
  7. 7.
    F. Yasuno, T. Suhara, Y Okubo, Y Sudo, M. Inoue, T. Ichimiya, S. Tanada, Dose relation of limbic-cortical D2-dopamine receptor occupancy with risperidone. Psychopharmacology 154, 112–114 (2001)PubMedCrossRefGoogle Scholar
  8. 8.
    T Suhara, Y Okubo, F. Yasuno, Y Sudo, M. Inoue, T. Ichimiya, Y Nakashima, K. Nakayama, S. Tanada, K. Suzuki, C. Halldin, L. Farde, Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia. Arch. Gen. Psych, in pressGoogle Scholar
  9. 9.
    H. Ito, Y Sudo, T. Suhara, Y Okubo, C. Halldin, L. Farde, Error analysis for quantification of [11C]FLB 457 binding to extrastriatal dopamine D2 receptor in the human brain. Neurolmage 13, 531–539 (2001)CrossRefGoogle Scholar
  10. 10.
    T. Okauchi, T. Suhara, J. Maeda, K. Kawabe, S. Obayashi, K. Suzuki, Effect of endogenous dopamine on extrastriatal [11C]FLB 457 binding measured by PET. Synapse 41, 87–95 (2001)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Tetsuya Suhara
    • 1
  • Fumihiko Yasuno
  • Yoshiro Okubo
  • Yasuhiko Sudo
  • Makoto Inoue
  • Tetsuya Ichimiya
  • Akihiro Takano
  1. 1.Brain Imaging ProjectNational Institute of Radiological SciencesInage-ku, ChibaJapan

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