Dopamine Psychosis in Schizophrenia? Molecular Genetic Study on Delusional Disorder

  • Kiyoshi Morimoto
  • Ryosuke Miyatake
  • Mitsuo Nakamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)


Delusional disorder is characterized by mono-symptomatic paranoid symptoms without other schizophrenic symptoms. Thus, delusional disorder can be a good clinical model for investigating the molecular genetic mechanisms for paranoid symptoms. In this study, we hypothesized that a hyperdopaminergic state in the brain is responsible for producing paranoid symptoms. To test this hypothesis, we (1) compared neuroleptic responses between patients with delusional disorder and schizophrenia, (2) measured plasma levels of homovanillic acid (pHVA), an indicator of brain dopamine activity, in patients with delusional disorder, and (3) analysed the polymorphism of dopamine receptors (DRs) and its synthesizing enzyme gene.


Tyrosine Hydroxylase Brief Psychiatric Rate Scale DRD3 Gene Delusional Disorder Tyrosine Hydroxylase Gene 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kiyoshi Morimoto
  • Ryosuke Miyatake
  • Mitsuo Nakamura
    • 1
  1. 1.Department of Neuropsychiatry, Faculty of MedicineKagawa Medical UniversityKagawaJapan

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