Dopamine Psychosis in Schizophrenia? Molecular Genetic Study on Delusional Disorder

  • Kiyoshi Morimoto
  • Ryosuke Miyatake
  • Mitsuo Nakamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Delusional disorder is characterized by mono-symptomatic paranoid symptoms without other schizophrenic symptoms. Thus, delusional disorder can be a good clinical model for investigating the molecular genetic mechanisms for paranoid symptoms. In this study, we hypothesized that a hyperdopaminergic state in the brain is responsible for producing paranoid symptoms. To test this hypothesis, we (1) compared neuroleptic responses between patients with delusional disorder and schizophrenia, (2) measured plasma levels of homovanillic acid (pHVA), an indicator of brain dopamine activity, in patients with delusional disorder, and (3) analysed the polymorphism of dopamine receptors (DRs) and its synthesizing enzyme gene.

Keywords

Tyrosine Hydroxylase Brief Psychiatric Rate Scale DRD3 Gene Delusional Disorder Tyrosine Hydroxylase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Garver DL, Steinberg JL, McDermott BE, et al: Etiologic heterogeneity of the psychoses: is there a dopamine psychosis? Neuropsychopharmacol 14:191–201, 1997.CrossRefGoogle Scholar
  2. Arinami T, Itokawa M, Enguchi H, et al: Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet 343:703–704, 1994.PubMedCrossRefGoogle Scholar
  3. Arinami T, Itokawa M, Aoki J, et al: Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorder. Am J Med Genet 67:133–138, 1996.PubMedCrossRefGoogle Scholar
  4. Serretti A, Latuada E, Lorenzi R, et al: Dopamine receptor D2 Ser/Cys311 is associated with delusion and disorganization symptomatology in major psychoses. Mol Psychiatry 5:270–274, 2000.PubMedCrossRefGoogle Scholar
  5. Crocq MA, Mant R, Asherson P, et al: Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 29:858–860, 1992.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kiyoshi Morimoto
  • Ryosuke Miyatake
  • Mitsuo Nakamura
    • 1
  1. 1.Department of Neuropsychiatry, Faculty of MedicineKagawa Medical UniversityKagawaJapan

Personalised recommendations